This 161.7-mile drive from Brandon, MS, to Biloxi, MS, is a straightforward, highway-focused journey that can easily be completed in about 3 hours and 25 minutes. Given its manageable distance and duration, it's perfectly suited for a single-day road trip, with an estimated fuel cost of around $24. The route primarily utilizes US 49, with portions of the Biloxi-D'Iberville Scenic Expressway and Highway 18 also incorporated. You'll be spending about 91% of your time on highways, making for a relatively efficient trip through the Southeast region of Mississippi.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
80.9 miles from Brandon, MS
A natural place for your longest stop of the day
, about 1h 46m into the drive
.
Main Roads
Road
Distance
Duration
US 49
95.9 mi
1h 54m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
Highway 18
16 mi
23m
Highway 13 North
9.2 mi
13m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
Louis Wilson Drive
2.6 mi
4m
Longest stretch:
US 49
— 95.9 mi, about 1h 54m
Turn-by-Turn Driving Directions
Step-by-step road directions between Brandon, MS and Biloxi, MS.
1
Start on US 80
0.3 mi·27 sec·East Government Street
2
Turn right onto Louis Wilson Drive
2.6 mi·4 min·Louis Wilson Drive
Use the right lane.
3
At end of road, turn left onto MS 18
16 mi·23 min·Highway 18
4
Turn right onto MS 13
9.2 mi·13 min·Highway 13 North
5
Take the ramp
0.2 mi·22 sec
6
Merge onto US 49
53 mi·1 hr 3 min·US 49
Use the straight lane.
7
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
8
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
9
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
10
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
11
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
12
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
13
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
14
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
15
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
16
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
17
Continue on I 110
3.2 mi·4 min·I 110
18
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
19
Turn left onto Division Street
0.6 mi·1 min·Division Street
20
Turn right onto Main Street
0.5 mi·1 min·Main Street
21
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
22
Arrive at destination
Howard Avenue
Trip Plan
This 3-hour and 25-minute drive is ideal for a single-day excursion, so you have flexibility with your departure time. Consider leaving in the morning to maximize your day in Biloxi. With only one recommended stop factored in, you can decide if you need a break during the 95.9-mile stretch on US 49. Keep an eye on your fuel gauge, as the estimated cost is $24, and plan your refueling accordingly, especially before embarking on longer highway segments. The highway-focused nature means you can cover ground quickly, making it easy to adjust your schedule on the fly.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 80.9 miles from Brandon, MS, or about 1h 46m into the drive.
The longest continuous stretch on this route runs about 95.9 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 36 miles or 52m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 80.9 miles or 1h 46m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 48m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Brandon, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Brandon, MS
This is one driving day of about 161.7 miles and 3h 25m.
Your first comfortable stop window is around 36 miles from Brandon, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 95.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 82.2 and 93.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
82.2 mi into trip|~1h 48m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
6
82.6 mi into trip|~1h 49m in|I 59 / Lance Corporal Roy M Wheat Memorial Highway
Merge onto I 59 / Lance Corporal Roy M Wheat Memorial Highway toward Mississippi Gulf Coast
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
Toward Mississippi Gulf Coast
7
90.3 mi into trip|~1h 57m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
93.5 mi into trip|~2h 1m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
93.8 mi into trip|~2h 2m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Fuel & Cost
Regular Gas
$24.42 one way
$48.84 round trip
$3.84/gal25.4 MPG avg57 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$26.81
$53.62
premium
$4.56
$29.02
$58.05
diesel
$5.61
$35.70
$71.40
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$24
Meals
$25–$50
Total
$49–$74
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 56.6 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $17 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
48.5
0
$16.98
$7.76
Efficient EV
40.4
0
$14.15
$6.47
EV Truck/SUV
64.7
0
$22.64
$10.35
Gas CO2
57 kg
EV CO2
19 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 17, 2026
Origin
Brandon, MS
Late night
in Brandon on Sunday
Local time
2:48 AM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Biloxi, MS
Late night
in Biloxi on Sunday
Local time
2:48 AM
CDT
Current temp
61°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
3h 25m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a predominantly highway experience on this route, with 91% of the drive taking place on faster roads. The longest uninterrupted stretch you'll encounter is 95.9 miles on US 49, offering a good period of consistent travel. While the profile is highway-focused, the inclusion of roads like the Biloxi-D'Iberville Scenic Expressway suggests potential for slightly varied scenery or a change in road type as you near your destination. Overall, this drive is designed for getting you from point A to point B with efficiency, rather than focusing on a winding, scenic byway experience.
91% highway — fuel and pacing are the main things to plan.
22 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 95.9 mi on US 49.
How Hard Is This Drive?
7/10
This is a straightforward highway drive that stays mostly on US 49 and Biloxi-D'Iberville Scenic Expressway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 82.2 miles in.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 15 significant decision points across 161.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 82.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 82.6 miles (I 59 / Lance Corporal Roy M Wheat Memorial Highway): Merge point - match speed before joining. Lane positioning matters here; at 90.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Brandon, MS and Biloxi, MS, road signs point toward Gulf Coast, Mississippi Gulf Coast, Mobile, Gulfport, Multi Purpose Center and Hattiesburg.
Gulf Coast
82.2 mi in|~1h 48m
Mississippi Gulf Coast
82.6 mi in|~1h 49m|via I 59
Mobile
90.3 mi in|~1h 57m|via US 98
Gulfport
93.5 mi in|~2h 1m
Multi Purpose Center
93.8 mi in|~2h 2m
Hattiesburg
93.8 mi in|~2h 2m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 3h 25m. Total distance: 161.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 25m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (91%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 95.9 miles on US 49. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Biloxi, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 82.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 82.6 miles (I 59 / Lance Corporal Roy M Wheat Memorial Highway): Merge point - match speed before joining. Lane positioning matters here; at 90.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 3.4 hours each way, an in-and-out day trip would put you behind the wheel for 6.9 hours — manageable with a long break at Biloxi, MS, but most travelers stay overnight.
