Hattiesburg to Biloxi is 73.9 miles and takes about 1 hour 34 minutes via US 49 and I-110, with a fuel budget near $11 and enough daylight to finish in a day. This journey takes you from the Southeast region of Mississippi to the same region, primarily on well-maintained highways. Expect a straightforward drive with minimal complexity, making it an ideal choice for a quick trip or an add-on to another adventure. The relatively short distance and clear route mean you'll spend more time at your destination and less time on the road.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
37 miles from Hattiesburg, MS
A natural place for your longest stop of the day
, about 47m into the drive
.
Main Roads
Road
Distance
Duration
US 49
44.4 mi
52m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
I 110
3.2 mi
4m
Edwards Street
2.8 mi
6m
Division Street
0.6 mi
1m
Main Street
0.5 mi
1m
Bay Street
0.5 mi
1m
North Main Street
0.3 mi
<1m
Longest stretch:
US 49
— 44.4 mi, about 52m
Turn-by-Turn Driving Directions
Step-by-step road directions between Hattiesburg, MS and Biloxi, MS.
1
Start on US 11
27 ft·8 sec·East Pine Street
2
Turn left onto MS 969
0.3 mi·55 sec·North Main Street
3
Continue on MS 969
0.5 mi·1 min·Bay Street
4
Enter roundabout onto James Street
151 ft·3 sec·James Street
5
Continue on James Street
476 ft·13 sec·James Street
6
Turn right onto Edwards Street
2.8 mi·6 min·Edwards Street
Use the right lane.
7
Turn left onto US 49
0.3 mi·27 sec·US 49
Use the left / straight / right lanes.
8
Continue on US 49
2.1 mi·2 min·US 49
Use the straight lane.
9
Turn straight onto US 49
42 mi·49 min·US 49
Use the straight lane.
10
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
11
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
12
Continue on I 110
3.2 mi·4 min·I 110
13
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
14
Turn left onto Division Street
0.6 mi·1 min·Division Street
15
Turn right onto Main Street
0.5 mi·1 min·Main Street
16
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
17
Arrive at destination
Howard Avenue
Trip Plan
Given the short duration of 1 hour and 34 minutes, this trip offers a lot of flexibility. You can easily depart in the morning and arrive well before lunchtime, or even make it a late afternoon excursion. With only 73.9 miles and a low fuel cost of about $11, you won't need to worry much about frequent stops. However, it's always wise to take a break after about 45 miles, especially during the longest stretch on US 49, to stay alert. Keep an eye out for the transition from US 49 to the Biloxi-D'Iberville Scenic Expressway as your primary route into the coastal area.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 37 miles from Hattiesburg, MS, or about 47m into the drive.
The longest continuous stretch on this route runs about 44.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 16 miles or 23m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 37 miles or 47m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 18m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Hattiesburg, MS so your first major turns are already loaded.
Day 1
Settle into the route from Hattiesburg, MS
This is one driving day of about 73.9 miles and 1h 34m.
Your first comfortable stop window is around 16 miles from Hattiesburg, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on US 49 for about 44.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 9
5 decision points cluster between mile 0 and 72.5 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|MS 969 / North Main Street
Turn left onto MS 969 / North Main Street
Navigation decision point
5
0.8 mi into trip|~2m in|James Street
Enter roundabout onto James Street
Roundabout - know your exit number before entering
5
0.9 mi into trip|~2m in|Edwards Street
Turn right onto Edwards Street
Lane positioning matters here
Use the right lane.
5
48.1 mi into trip|~1h 1m in
Take the exit toward MS 67 South: D'Iberville, Biloxi
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward MS 67 South: D'Iberville, Biloxi
5
72.5 mi into trip|~1h 30m in
Take the exit toward Division Street
Exit ramp - move to the correct lane early
Exit 1c
Toward Division Street
Fuel & Cost
Regular Gas
$11.16 one way
$22.32 round trip
$3.84/gal25.4 MPG avg26 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$12.25
$24.50
premium
$4.56
$13.26
$26.53
diesel
$5.61
$16.32
$32.63
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$11
Meals
$25–$50
Total
$36–$61
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 25.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $8 in charging
· 0 stops
· 65% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
22.2
0
$7.76
$3.55
Efficient EV
18.5
0
$6.47
$2.96
EV Truck/SUV
29.6
0
$10.35
$4.73
Gas CO2
26 kg
EV CO2
9 kg (65% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 19, 2026
Origin
Hattiesburg, MS
Late night
in Hattiesburg on Tuesday
Local time
5:35 AM
CDT
Current temp
72°F
Mostly Sunny
NNE 10 to 15 mph0% chanceLive forecast
Destination
Biloxi, MS
Late night
in Biloxi on Tuesday
Local time
5:35 AM
CDT
Current temp
78°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
6 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
1h 34m on the road
The weather snapshot is not static. If you are leaving later, give both cities one more quick forecast check before departure.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This route is heavily focused on highway driving, with 92% of the journey utilizing major roadways. You'll experience a highway-focused drive for the most part, including a significant stretch of 44.4 miles on US 49 before transitioning to the Biloxi-D'Iberville Scenic Expressway and I-110. The character of the drive is consistent, emphasizing efficiency and direct travel. While not a winding scenic byway, it offers a clear path with predictable conditions for most of the 73.9 miles.
92% highway — fuel and pacing are the main things to plan.
17 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 44.4 mi on US 49.
How Hard Is This Drive?
4/10
This is a straightforward highway drive that stays mostly on US 49 and Biloxi-D'Iberville Scenic Expressway. There are only a few real navigation decisions along the way. The trickiest moment comes early in the drive near MS 969 / North Main Street.
Driving Effort4/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 1h 34m drive. You will face about 9 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: near the start (MS 969 / North Main Street): Navigation decision point; at 0.8 miles (James Street): Roundabout - know your exit number before entering; at 0.9 miles (Edwards Street): Lane positioning matters here.
Hattiesburg is a city in Forrest County, in the Gulf Coast region of Mississippi. It is best known for being the home of the University of Southern Mississippi.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
The longest stretch is about 44.4 miles on US 49. The full list of main roads is in the Roads section above.
Yes. At under 2 hours behind the wheel, this works well for families — plan one quick stop if you have younger kids.
The main spots that need attention: near the start (MS 969 / North Main Street): Navigation decision point; at 0.8 miles (James Street): Roundabout - know your exit number before entering; at 0.9 miles (Edwards Street): Lane positioning matters here.
Yes. A round trip is manageable in a single day if you plan a break at Biloxi, MS before heading back.
