Traveling from Oxford to Biloxi covers 323.7 miles of Mississippi terrain, typically requiring about 6 hours and 20 minutes behind the wheel. Because this journey stays within the Southeast region, you will experience a consistent cultural backdrop as you transition from the northern hills to the Gulf Coast. Budget approximately $49 for fuel to complete this trip, which is manageable as a single-day drive if you start early. While the route is straightforward, it is long enough that you might consider an overnight stay if you prefer a more leisurely pace. This highway-focused path is ideal for travelers prioritizing efficiency over scenic detours.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
161.8 miles from Oxford, MS
A natural place for your longest stop of the day
, about 3h 2m into the drive
.
Main Roads
Road
Distance
Duration
MS 7
144.2 mi
2h 39m
Highway 49 South
80.3 mi
1h 37m
US 49
44.1 mi
53m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
I 55
15.6 mi
18m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
Longest stretch:
MS 7
— 144.2 mi, about 2h 39m
Turn-by-Turn Driving Directions
Step-by-step road directions between Oxford, MS and Biloxi, MS.
1
Start on Courthouse Square
148 ft·11 sec·Courthouse Square
2
Continue on Courthouse Square
92 ft·4 sec·Courthouse Square
3
Turn right
55 ft·2 sec
4
Turn right onto South Lamar Boulevard
0.1 mi·26 sec·South Lamar Boulevard
5
Turn left onto MS 314
0.7 mi·1 min·University Avenue
6
Enter roundabout
36 ft·0 sec
7
Continue
0.2 mi·19 sec
8
Merge onto MS 7
6.8 mi·9 min·MS 7
9
Enter roundabout onto MS 7
124 ft·1 sec·MS 7
Toward MS 7 South: Water Valley
10
Continue on MS 7
36 mi·41 min·MS 7
Toward MS 7 South: Water Valley
11
Take the exit onto MS 7
101 mi·1 hr 48 min·MS 7
12
Continue on I 55
16 mi·18 min·I 55
13
Take the exit
0.9 mi·1 min
Toward I 20 East, US 49 South: Meridian, Hattiesburg
14
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
15
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
16
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
17
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
18
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
19
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
20
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
21
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
22
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
23
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
24
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
25
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
26
Continue on I 110
3.2 mi·4 min·I 110
27
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
28
Turn left onto Division Street
0.6 mi·1 min·Division Street
29
Turn right onto Main Street
0.5 mi·1 min·Main Street
30
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
31
Arrive at destination
Howard Avenue
Trip Plan
Since this is a 6-hour and 20-minute journey, departing early in the morning is your best bet to avoid peak traffic near major hubs. Plan for at least one dedicated stop to stretch your legs and refuel, as the long, straight highway stretches can lead to driver fatigue. With a fuel budget of $49, keep an eye on your gauge during the 144.2-mile stretch on MS 7 where services may be spaced further apart. Because this route is primarily highway-focused, utilize your cruise control to maintain a steady pace across the state. Remember that having only one planned stop provides you with the flexibility to adjust your schedule if road conditions change during the day.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 161.8 miles from Oxford, MS, or about 3h 2m into the drive.
The longest continuous stretch on this route runs about 144.2 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 71 miles or 1h 22m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 161.8 miles or 3h 2m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 8m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Oxford, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Oxford, MS
This is one driving day of about 323.7 miles and 6h 20m.
Your first comfortable stop window is around 71 miles from Oxford, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on MS 7 for about 144.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 20
5 decision points cluster between mile 161.7 and 255.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
161.7 mi into trip|~3h 1m in|US 49
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Richland, Hattiesburg
7
244.2 mi into trip|~4h 43m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
252.3 mi into trip|~4h 52m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
255.5 mi into trip|~4h 56m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
255.8 mi into trip|~4h 56m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Fuel & Cost
Regular Gas
$48.89 one way
$97.77 round trip
$3.84/gal25.4 MPG avg113 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$53.67
$107.33
premium
$4.56
$58.10
$116.20
diesel
$5.61
$71.47
$142.94
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$49
Meals
$25–$50
Total
$74–$99
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 113.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $34 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
97.1
1
$33.99
$15.54
Efficient EV
80.9
0
$28.32
$12.95
EV Truck/SUV
129.5
1
$45.32
$20.72
Gas CO2
113 kg
EV CO2
38 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 17, 2026
Origin
Oxford, MS
Evening
in Oxford on Saturday
Local time
8:26 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Biloxi, MS
Evening
in Biloxi on Saturday
Local time
8:26 PM
CDT
Current temp
79°F
Sunny
S 10 mph0% chanceLive forecast
55°F
Florence, MS
162 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 20m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
3 mi from route
~8 min detour
Free
near mile 156.3
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a focused, highway-heavy experience, as 96% of this 323.7-mile route consists of high-speed travel. You will spend the bulk of your time on MS 7, Highway 49 South, and US 49 as you navigate toward the coast. The longest uninterrupted stretch occurs early on, with 144.2 miles on MS 7, requiring steady focus and endurance. As you progress toward Biloxi, the road transitions from regional highway connections to the more heavily traveled US 49 corridors. It is a no-nonsense drive that favors constant forward momentum over technical maneuvering.
96% highway — fuel and pacing are the main things to plan.
31 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 144.2 mi on MS 7.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on MS 7 and Highway 49 South. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 161.7 miles in near US 49.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 323.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 161.7 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 244.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 252.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Oxford, MS and Biloxi, MS, road signs point toward Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast, Mobile and Gulfport - among others.
Oxford is a historic, picturesque town in North Central Mississippi. With its scenic town square, acclaimed restaurants, unique boutiques, oak-shaded neighborhoods, and friendly people, Oxford is the model Southern town. Named after Oxford, England, in hopes of attracting a university, the town was selected as the home of the University of Mississippi in 1848, which dominates life here today.
Doable as a same-day drive at 6h 20m. Total distance: 323.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 20m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 144.2 miles on MS 7. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Biloxi, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 161.7 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 244.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 252.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.3 hours each way, a round trip means 12.7 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Biloxi, MS before the return drive.
