Traversing Mississippi from the coast to the northern border is a substantial journey covering 357.1 miles. You should budget approximately 6 hours and 55 minutes of drive time, making this a long but manageable single-day trip for most drivers. With a fuel cost estimate of $55, it is an affordable way to cross the state. You will primarily utilize I-55, US 49, and MS 15 to navigate from the Southeast region toward the Memphis metropolitan area. Since this is a highway-focused drive, it is best suited for those looking to reach their destination efficiently rather than those seeking a leisurely backroads tour.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
178.6 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 3h 39m into the drive
.
Main Roads
Road
Distance
Duration
I 55
193.7 mi
3h 29m
US 49
135 mi
2h 46m
MS 15
20.7 mi
24m
I 110
3.1 mi
4m
Goodman Road West
2.1 mi
3m
Hurt Road
0.5 mi
2m
Division Street
0.5 mi
1m
Main Street
0.5 mi
1m
Longest stretch:
I 55
— 193.7 mi, about 3h 29m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Horn Lake, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
17
Take the exit onto US 49
0.2 mi·21 sec·US 49
18
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
19
Keep slight right at fork onto US 49
0.9 mi·1 min·US 49
20
Merge onto I 55
194 mi·3 hr 29 min·I 55
21
Take the exit
0.3 mi·38 sec
Toward Southaven, Horn Lake, Olive Branch
22
Keep slight left at fork
192 ft·6 sec
Toward Memphis
23
Turn left onto MS 302
2.1 mi·3 min·Goodman Road West
24
Turn left onto Hurt Road
0.5 mi·2 min·Hurt Road
25
Turn right onto Camelot Road
193 ft·8 sec·Camelot Road
26
Arrive at destination
Camelot Road
Trip Plan
To make the most of your 357.1-mile journey, try to depart early in the morning to avoid congestion as you approach the destination near Horn Lake. While the drive is feasible in one day, plan for at least one dedicated stop to stretch your legs and refuel. Keeping your budget around $55 for gas is a solid benchmark, but always check your vehicle's efficiency before heading out. Since you are spending nearly the entire duration on highways, stay alert during the long 193.7-mile stint on I-55 where fatigue can set in. Prioritizing consistent rest intervals will ensure you arrive safely after your seven-hour transit.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 178.6 miles from Biloxi, MS, or about 3h 39m into the drive.
The longest continuous stretch on this route runs about 193.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 79 miles or 1h 40m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 178.6 miles or 3h 39m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 47m
Traffic, exits, and arrival timing usually matter more near Horn Lake, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 357.1 miles and 6h 55m.
Your first comfortable stop window is around 79 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 55 for about 193.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 25.1 and 354.5 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
158.9 mi into trip|~3h 17m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
5
354.2 mi into trip|~6h 49m in
Take the exit toward Southaven, Horn Lake, Olive Branch
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward Southaven, Horn Lake, Olive Branch
6
354.5 mi into trip|~6h 50m in
Keep slight left at fork toward Memphis
Highway fork - watch signs carefully
Toward Memphis
Fuel & Cost
Regular Gas
$53.93 one way
$107.86 round trip
$3.84/gal25.4 MPG avg125 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$59.20
$118.41
premium
$4.56
$64.10
$128.19
diesel
$5.61
$78.84
$157.69
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$54
Meals
$25–$50
Total
$79–$104
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 124.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $38 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
107.1
1
$37.50
$17.14
Efficient EV
89.3
1
$31.25
$14.28
EV Truck/SUV
142.8
1
$49.99
$22.85
Gas CO2
125 kg
EV CO2
42 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Biloxi, MS
Evening
in Biloxi on Saturday
Local time
8:26 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Horn Lake, MS
Evening
in Horn Lake on Saturday
Local time
8:26 PM
CDT
Current temp
77°F
Unavailable
Live forecast
55°F
Florence, MS
179 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 55m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
5 mi from route
~13 min detour
Free
near mile 160.1
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
28 mi from route
~71 min detour
Free
near mile 295.6
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This trip is defined by its reliance on major thoroughfares, with 99% of the route consisting of highway driving. You will spend a significant portion of your time on the interstate, including a longest uninterrupted stretch of 193.7 miles along I-55. The personality of the road remains consistent and fast-paced, allowing you to maintain steady speeds throughout the trek. Because the route is so heavily prioritized for efficiency, you can expect a straightforward experience behind the wheel. Prepare for a predictable, high-speed transit that links the Gulf Coast to the northern reaches of the state.
99% highway — fuel and pacing are the main things to plan.
26 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 193.7 mi on I 55.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on I 55 and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 15 significant decision points across 357.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Biloxi, MS to Horn Lake, MS, road signs begin pointing toward Jackson along the way.
Jackson
25.1 mi in|~32m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 55m. Total distance: 357.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 55m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 193.7 miles on I 55. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Horn Lake, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Yes — Medgar and Myrlie Evers Home National Monument and Emmett Till and Mamie Till-Mobley National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.9 hours each way, a round trip means 13.9 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Horn Lake, MS before the return drive.
