Biloxi to North Tunica is 361.1 miles and takes about 7 hours 16 minutes via I 55, US 49, and MS 4, with a fuel budget near $55 and enough daylight to finish in a day. This route primarily stays within Mississippi, moving from the Southeast region toward the northern part of the state. With a recommended one-day drive, it's a straightforward trip that should feel familiar to anyone who's driven extensively on US highways. You'll find about two planned stops can help break up the drive, making it manageable for a single day.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
180.6 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 3h 41m into the drive
.
Main Roads
Road
Distance
Duration
I 55
169.8 mi
3h 3m
US 49
135 mi
2h 46m
MS 4
23.5 mi
41m
MS 15
20.7 mi
24m
US 61
4.1 mi
4m
I 110
3.1 mi
4m
MS 3
1.5 mi
2m
Main Street
1 mi
2m
Longest stretch:
I 55
— 169.8 mi, about 3h 3m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and North Tunica, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
17
Take the exit onto US 49
0.2 mi·21 sec·US 49
18
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
19
Keep slight right at fork onto US 49
0.9 mi·1 min·US 49
20
Merge onto I 55
170 mi·3 hr 3 min·I 55
21
Take the exit
0.2 mi·29 sec
Toward MS 4: Senatobia, Holly Springs
22
Turn left onto MS 4
1.1 mi·2 min·MS 4
23
Turn straight onto Main Street
0.5 mi·53 sec·Main Street
24
Continue on Old Highway 4
0.7 mi·1 min·Old Highway 4
25
Continue on MS 4
12 mi·21 min·MS 4
26
At end of road, turn right onto MS 3; MS 4
1.5 mi·2 min·MS 3; MS 4
27
Keep slight left at fork onto MS 4
10.0 mi·17 min·MS 4
28
Turn right onto US 61; MS 4
4.1 mi·4 min·US 61; MS 4
29
Turn left onto Prichard Road
0.1 mi·18 sec·Prichard Road
30
Turn right onto Sears Avenue
478 ft·26 sec·Sears Avenue
31
Turn left onto Gay Street
138 ft·6 sec·Gay Street
32
Arrive at destination
Gay Street
Trip Plan
Given the 7-hour drive time, starting early from Biloxi is your best bet to complete this route within daylight hours. You have two stops planned, so consider taking your first break around the halfway point or after the longest highway stretch on I 55. Keep an eye on your fuel gauge, especially on I 55, as services can sometimes be spread out. The $55 fuel cost is a good estimate, but always check local prices. Since this is a one-day trip, you have flexibility, but sticking to the main roads will ensure you reach North Tunica efficiently.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 180.6 miles from Biloxi, MS, or about 3h 41m into the drive.
The longest continuous stretch on this route runs about 169.8 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 79 miles or 1h 40m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 180.6 miles or 3h 41m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 52m
Traffic, exits, and arrival timing usually matter more near North Tunica, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 361.1 miles and 7h 16m.
Your first comfortable stop window is around 79 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on I 55 for about 169.8 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 1 and 330.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
1 mi into trip|~3m in|Bohn Street
Take the ramp onto Bohn Street
Navigation decision point
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
158.9 mi into trip|~3h 17m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
5
330.3 mi into trip|~6h 23m in
Take the exit toward MS 4: Senatobia, Holly Springs
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward MS 4: Senatobia, Holly Springs
Fuel & Cost
Regular Gas
$54.53 one way
$109.07 round trip
$3.84/gal25.4 MPG avg126 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$59.87
$119.73
premium
$4.56
$64.81
$129.63
diesel
$5.61
$79.73
$159.45
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$55
Meals
$25–$50
Total
$80–$105
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 126.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
28 DC fast chargers
· Coverage: excellent
North Bus Barn
Jackson, MS
NOODOE
14 DCFC
Lakeview Village Shopping Mall - Tesla Supercharger
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $38 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
108.3
1
$37.92
$17.33
Efficient EV
90.3
1
$31.60
$14.44
EV Truck/SUV
144.4
1
$50.55
$23.11
Gas CO2
126 kg
EV CO2
42 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Biloxi, MS
Evening
in Biloxi on Saturday
Local time
8:27 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
North Tunica, MS
Evening
in North Tunica on Saturday
Local time
8:27 PM
CDT
Current temp
63°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
7h 16m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~10 min detour
Free
near mile 161.9
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
29 mi from route
~72 min detour
Free
near mile 286.4
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This trip is almost entirely on highways, with 99% of the drive on paved roads designed for faster travel. You'll experience a longest stretch of 169.8 miles on I 55, indicating extended periods of consistent cruising. After this significant highway segment, you'll transition to US 49 and MS 4, which will likely offer a different feel, potentially with more local traffic and exits as you approach North Tunica.
99% highway — fuel and pacing are the main things to plan.
32 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 169.8 mi on I 55.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on I 55 and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 1 miles in near Bohn Street.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 361.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 1 miles (Bohn Street): Navigation decision point; at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and North Tunica, MS, road signs point toward Jackson and Holly Springs.
Jackson
25.1 mi in|~32m
Holly Springs
330.3 mi in|~6h 23m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 7h 16m. Total distance: 361.1 miles.
Family Friendly
Moderate complexity with 2 natural rest stops along the way.
Solo Traveler
7h 16m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 169.8 miles on I 55. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at North Tunica, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 1 miles (Bohn Street): Navigation decision point; at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here.
Not recommended in a single day. At 7.3 hours each way, a round trip means 14.5 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at North Tunica, MS before the return drive.
