Coldwater, MS to Biloxi, MS is 339.9 miles and takes about 6h 32m via I 55 and US 49, with a fuel budget near $54 and enough daylight to finish in a day. This trip stays within Mississippi, traversing the Southeast region. Expect a mostly highway experience, making it a straightforward drive. It's a good option if you're looking for a direct path between these two points without extensive detours.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
169.9 miles from Coldwater, MS
A natural place for your longest stop of the day
, about 3h 5m into the drive
.
Main Roads
Road
Distance
Duration
I 55
175.3 mi
3h 9m
Highway 49 South
80.3 mi
1h 37m
US 49
44.1 mi
53m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
MS 306
0.9 mi
1m
Longest stretch:
I 55
— 175.3 mi, about 3h 9m
Traffic on I-55
Hour-of-day weekday pattern from 53 FHWA count stations on your route.
Peak
4 PM
~2,578 veh/hr typical
Quietest
2 AM
~143 veh/hr
Peak-to-quiet ratio
18×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Coldwater, MS and Biloxi, MS.
1
Start on North Street
361 ft·17 sec·North Street
2
Turn right onto US 51; MS 304 Scenic
0.5 mi·46 sec·US 51; MS 304 Scenic
3
Turn right onto MS 306; MS 304 Scenic
0.9 mi·1 min·MS 306; MS 304 Scenic
4
Take the ramp
0.2 mi·29 sec
5
Merge onto I 55
175 mi·3 hr 9 min·I 55
6
Take the exit
0.9 mi·1 min
Toward I 20 East, US 49 South: Meridian, Hattiesburg
7
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
8
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
9
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
10
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
11
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
12
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
13
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
14
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
15
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
16
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
17
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
18
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
19
Continue on I 110
3.2 mi·4 min·I 110
20
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
21
Turn left onto Division Street
0.6 mi·1 min·Division Street
22
Turn right onto Main Street
0.5 mi·1 min·Main Street
23
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
24
Arrive at destination
Howard Avenue
Trip Plan
To make the most of this 6.5-hour drive, consider departing in the morning to allow ample daylight for navigation and any brief stops. With the majority of the route on I 55 and US 49, planning one fuel stop around the halfway point or slightly after the longest stretch on I 55 is advisable, especially given the estimated $54 fuel cost. While the drive is manageable in a single day, you have the flexibility to take your time. Keep an eye on the mileage, as the transition to US 49 marks a slight change in the road's profile.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 169.9 miles from Coldwater, MS, or about 3h 5m into the drive.
The longest continuous stretch on this route runs about 175.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 75 miles or 1h 22m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 169.9 miles or 3h 5m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 18m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Coldwater, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Coldwater, MS
This is one driving day of about 339.9 miles and 6h 32m.
Your first comfortable stop window is around 75 miles from Coldwater, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 55 for about 175.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 16
5 decision points cluster between mile 177.9 and 272 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
177.9 mi into trip|~3h 14m in|US 49
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Richland, Hattiesburg
7
260.4 mi into trip|~4h 55m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
268.5 mi into trip|~5h 4m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
271.7 mi into trip|~5h 8m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
272 mi into trip|~5h 9m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Fuel & Cost
Regular Gas
$47.18 one way
$94.37 round trip
$3.53/gal25.4 MPG avg119 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$3.95
$52.79
$105.58
premium
$4.29
$57.39
$114.79
diesel
$4.80
$64.18
$128.36
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$47
Meals
$25–$50
Total
$72–$97
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 118.9 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $36 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
102
1
$35.69
$16.32
Efficient EV
85
0
$29.74
$13.60
EV Truck/SUV
136
1
$47.59
$21.75
Gas CO2
119 kg
EV CO2
40 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 17, 2026
Origin
Coldwater, MS
Afternoon
in Coldwater on Saturday
Local time
3:44 PM
CDT
Current temp
93°F
Sunny
W 5 to 10 mph5% chanceLive forecast
Destination
Biloxi, MS
Afternoon
in Biloxi on Saturday
Local time
3:44 PM
CDT
Current temp
95°F
Mostly Sunny
W 5 to 10 mph7% chanceLive forecast
96°F
Sumrall, MS
170 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 32m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~10 min detour
Free
near mile 175.8
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
28 mi from route
~71 min detour
Free
near mile 46.9
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This drive is predominantly on highways, with 96% of it utilizing major roadways. You'll encounter a long stretch of 175.3 miles on I 55, suggesting a significant portion of consistent cruising. The transition to surface roads will occur later in the trip as you approach your destination. Expect a high number of exits and potential for varied traffic as you pass through different areas.
96% highway — fuel and pacing are the main things to plan.
24 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 175.3 mi on I 55.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on I 55 and Highway 49 South. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 177.9 miles in near US 49.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 16 significant decision points across 339.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 177.9 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 260.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 268.5 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
522 ft20 ft
Total Climb
539 ft
Total Descent
765 ft
Highest Point
522 ft
~194.2 mi in
Elevation Range
502 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Coldwater, MS and Biloxi, MS, road signs point toward Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast, Mobile and Gulfport - among others.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Top landmarks
•Jefferson Davis Presidential Library and Museum — presidential library and museum for Confederate States President Jefferson Davis...
•Beauvoir — post-war home of the former President of the Confederate States of America, Jeff...
•Biloxi Light — lighthouse in Mississippi, United States
Doable as a same-day drive at 6h 32m. Total distance: 339.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 32m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 175.3 miles on I 55. The full list of main roads is in the Roads section above.
Yes — we found about 1 rest area or service plaza within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Biloxi, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 1 rest area along the route for bathroom stops.
The main spots that need attention: at 177.9 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 260.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 268.5 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument and Emmett Till and Mamie Till-Mobley National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.5 hours each way, a round trip means 13.1 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Biloxi, MS before the return drive.
