Traveling from Hattiesburg to Greenville covers 208 miles of Mississippi landscape, typically taking about 3 hours and 39 minutes of drive time. Because this is a turn-heavy local drive rather than a straightforward interstate haul, it is best suited as a single-day trip. You should set aside roughly $32 for fuel to complete the journey. Navigating through the Southeast, you will transition from the Hattiesburg area toward the Mississippi Delta region. While the route is manageable in one go, staying mindful of the local road conditions will help you maintain a steady pace throughout the afternoon.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
104.9 miles from Hattiesburg, MS
A natural place for your longest stop of the day
, about 2h 12m into the drive
.
Main Roads
Road
Distance
Duration
US 49
90.3 mi
1h 51m
US 49W
46.7 mi
56m
Medgar Evers Boulevard
39.5 mi
48m
US 82
15.8 mi
19m
MS 182
8.3 mi
12m
I 20
4.3 mi
5m
Old Highway 42
1.7 mi
3m
North Main Street
1.3 mi
3m
Longest stretch:
US 49
— 90.3 mi, about 1h 51m
Turn-by-Turn Driving Directions
Step-by-step road directions between Hattiesburg, MS and City of Greenville, MS.
1
Start on US 11
27 ft·5 sec·East Pine Street
2
Turn right onto MS 967
1.3 mi·3 min·North Main Street
Use the straight / right lanes.
3
At end of road, turn left onto Old Highway 42
1.7 mi·3 min·Old Highway 42
Use the straight lane.
4
Turn slight right
0.1 mi·12 sec
Use the straight / slight right lanes.
5
Turn straight onto US 49
2.2 mi·3 min·US 49
Use the straight lane.
6
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
7
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
8
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
9
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
10
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
11
Take the exit onto US 49
0.2 mi·21 sec·US 49
12
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
13
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
14
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
15
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
16
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
17
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
18
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
19
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
20
Turn left onto US 82
2.4 mi·3 min·US 82
21
Keep slight left at fork onto US 82
0.4 mi·29 sec·US 82
22
Keep slight left at fork onto US 82
13 mi·15 min·US 82
23
Turn right onto MS 182
8.3 mi·12 min·MS 182
24
Turn left onto MS 1
1.0 mi·1 min·Martin Luther King Junior Boulevard
25
Turn right onto East Reed Road
0.7 mi·1 min·East Reed Road
26
Turn left onto Sandy Avenue
46 ft·2 sec·Sandy Avenue
27
Arrive at destination
Sandy Avenue
Trip Plan
Plan for at least one dedicated stop to break up the nearly four-hour journey and give yourself a chance to stretch. Since this route relies on local roads rather than major interstates, prioritize leaving early in the day to avoid potential congestion in larger towns like Jackson. Keep your fuel gauge in mind, as the $32 estimate is a baseline that can fluctuate based on your vehicle's efficiency on lower-speed, winding roads. Given the turn-heavy nature of the path, using a reliable GPS is essential to stay on course through the various local transitions. Flexibility is your biggest advantage here, so don't hesitate to pull over for a quick rest if the local traffic flow feels demanding.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 104.9 miles from Hattiesburg, MS, or about 2h 12m into the drive.
The longest continuous stretch on this route runs about 90.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 46 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 104.9 miles or 2h 12m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 34m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Hattiesburg, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Hattiesburg, MS
This is one driving day of about 209.9 miles and 4h 23m.
Your first comfortable stop window is around 46 miles from Hattiesburg, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 90.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 18
5 decision points cluster between mile 0 and 92.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
0 mi into trip|~0m in|MS 967 / North Main Street
Turn right onto MS 967 / North Main Street
Lane positioning matters here
Use the straight / right lanes.
6
1.3 mi into trip|~3m in|Old Highway 42
At end of road, turn left onto Old Highway 42
Lane positioning matters here
Use the straight lane.
5
86.2 mi into trip|~1h 48m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
6
89.6 mi into trip|~1h 53m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
5
92.3 mi into trip|~1h 56m in|US 49
Take the exit onto US 49 toward I 220 North, I 49 North: North Jackson, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 220 North, I 49 North: North Jackson,...
Fuel & Cost
Regular Gas
$31.70 one way
$63.40 round trip
$3.84/gal25.4 MPG avg73 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$34.80
$69.60
premium
$4.56
$37.67
$75.35
diesel
$5.61
$46.34
$92.69
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$32
Meals
$25–$50
Total
$57–$82
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 73.4 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $22 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
63
0
$22.04
$10.08
Efficient EV
52.5
0
$18.37
$8.40
EV Truck/SUV
84
1
$29.39
$13.43
Gas CO2
73 kg
EV CO2
25 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Hattiesburg, MS
Late night
in Hattiesburg on Sunday
Local time
5:53 AM
CDT
Current temp
80°F
Unavailable
Live forecast
Destination
City of Greenville, MS
Late night
in City of Greenville on Sunday
Local time
5:53 AM
CDT
Current temp
80°F
Unavailable
Live forecast
54°F
Clinton, MS
105 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
4h 23m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a road trip defined by local character rather than high-speed interstate cruising, as this route features a 0% highway share. You will spend your time navigating via North Main Street, Highway 42, and through the Jackson area, which requires your full attention behind the wheel. Because the path is composed of turn-heavy local roads, you will find yourself dealing with frequent changes in direction instead of long, monotonous stretches of asphalt. This drive requires a more engaged driving style, so be prepared to navigate through various local intersections and transition zones as you cross the state.
80% highway — fuel and pacing are the main things to plan.
27 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 90.3 mi on US 49.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near MS 967 / North Main Street.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 209.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (MS 967 / North Main Street): Lane positioning matters here; at 1.3 miles (Old Highway 42): Lane positioning matters here; at 86.2 miles (US 49): Highway fork - watch signs carefully.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Hattiesburg, MS and City of Greenville, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Jackson
86.2 mi in|~1h 48m|via US 49
Yazoo City
89.6 mi in|~1h 53m|via I 20; US 49
Vicksburg
137.3 mi in|~2h 52m|via US 49W
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 23m. Total distance: 209.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 23m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (80%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 90.3 miles on US 49. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at City of Greenville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (MS 967 / North Main Street): Lane positioning matters here; at 1.3 miles (Old Highway 42): Lane positioning matters here; at 86.2 miles (US 49): Highway fork - watch signs carefully.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.4 hours each way, an in-and-out day trip would put you behind the wheel for 8.8 hours — manageable with a long break at City of Greenville, MS, but most travelers stay overnight.
