Spanning 284.4 miles across Mississippi, this drive from Ocean Springs to Greenville connects the Southeast coast to the heart of the Delta. You should plan for roughly 5 hours and 54 minutes of travel time, making this a manageable, albeit long, single-day trip. With an estimated fuel cost of $43, it is an affordable journey if you prefer to head straight to your destination without an overnight stay. Since the entire route stays within the state of Mississippi, you will experience a consistent regional feel while transitioning from the coastal environment toward the inland plains. Keep in mind that while one stop is recommended to break up the journey, the route is straightforward enough to complete in one go if you are prepared for the time behind the wheel.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
142.2 miles from Ocean Springs, MS
A natural place for your longest stop of the day
, about 2h 56m into the drive
.
Main Roads
Road
Distance
Duration
US 49
140.6 mi
2h 53m
US 49W
46.7 mi
56m
Medgar Evers Boulevard
39.5 mi
48m
Biloxi-D'Iberville Scenic Expressway
20.4 mi
23m
US 82
15.8 mi
19m
MS 182
8.3 mi
12m
I 20
4.3 mi
5m
Washington Avenue
3.3 mi
6m
Longest stretch:
US 49
— 140.6 mi, about 2h 53m
Turn-by-Turn Driving Directions
Step-by-step road directions between Ocean Springs, MS and City of Greenville, MS.
1
Start on Washington Avenue
3.3 mi·6 min·Washington Avenue
Use the left / straight lanes.
2
Turn left
0.4 mi·49 sec
3
Merge onto I 10
2.2 mi·2 min·I 10
4
Take the exit
0.2 mi·20 sec
Exit 46D-BToward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
5
Keep slight left at fork
0.2 mi·23 sec
6
Keep slight right at fork
0.4 mi·46 sec
Exit 46CToward MS 15, MS 67: MS 15, MS 67
7
Merge onto MS 15; MS 67
20 mi·23 min·Biloxi-D'Iberville Scenic Expressway
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
17
Take the exit onto US 49
0.2 mi·21 sec·US 49
18
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
19
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
20
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
21
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
22
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
23
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
24
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
25
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
26
Turn left onto US 82
2.4 mi·3 min·US 82
27
Keep slight left at fork onto US 82
0.4 mi·29 sec·US 82
28
Keep slight left at fork onto US 82
13 mi·15 min·US 82
29
Turn right onto MS 182
8.3 mi·12 min·MS 182
30
Turn left onto MS 1
1.0 mi·1 min·Martin Luther King Junior Boulevard
31
Turn right onto East Reed Road
0.7 mi·1 min·East Reed Road
32
Turn left onto Sandy Avenue
46 ft·2 sec·Sandy Avenue
33
Arrive at destination
Sandy Avenue
Trip Plan
To make the most of your 284.4-mile trek, try to depart early in the morning to avoid any potential traffic buildup on the primary highways. Since you have a single recommended stop, look for a mid-way point along US 49 to stretch your legs and refuel before entering the final stretch. Budgeting $43 for gas should be sufficient, but keep an eye on your gauge during the long 140.6-mile segment to ensure you do not run low between service areas. Because the route is a single-day commitment, your flexibility is a major advantage; you can easily adjust your pace to arrive in Greenville by late afternoon. Always double-check your navigation before hitting the junction where US 49 transitions to US 49W to ensure a smooth transition to your final destination.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 142.2 miles from Ocean Springs, MS, or about 2h 56m into the drive.
The longest continuous stretch on this route runs about 140.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 63 miles or 1h 17m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 142.2 miles or 2h 56m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 49m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Ocean Springs, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Ocean Springs, MS
This is one driving day of about 284.4 miles and 5h 54m.
Your first comfortable stop window is around 63 miles from Ocean Springs, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 140.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 23
5 decision points cluster between mile 5.8 and 164.1 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
5.8 mi into trip|~9m in
Take the exit toward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 46D-B
Toward I 110, MS 15, MS 67: Biloxi, Keesler Air...
5
6 mi into trip|~9m in
Keep slight left at fork
Highway fork - watch signs carefully
7
6.2 mi into trip|~10m in
Keep slight right at fork toward MS 15, MS 67: MS 15, MS 67
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 46C
Toward MS 15, MS 67: MS 15, MS 67
6
27 mi into trip|~34m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
6
164.1 mi into trip|~3h 24m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
Fuel & Cost
Regular Gas
$42.95 one way
$85.90 round trip
$3.84/gal25.4 MPG avg100 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$47.15
$94.30
premium
$4.56
$51.05
$102.09
diesel
$5.61
$62.79
$125.58
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$43
Meals
$25–$50
Total
$68–$93
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 99.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $30 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
85.3
1
$29.86
$13.65
Efficient EV
71.1
0
$24.88
$11.38
EV Truck/SUV
113.8
1
$39.82
$18.20
Gas CO2
100 kg
EV CO2
33 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 12, 2026
Origin
Ocean Springs, MS
Morning
in Ocean Springs on Sunday
Local time
7:12 AM
CDT
Current temp
67°F
Mostly Clear
SE 5 mph0% chanceLive forecast
Destination
City of Greenville, MS
Morning
in City of Greenville on Sunday
Local time
7:12 AM
CDT
Current temp
80°F
Unavailable
Live forecast
55°F
Florence, MS
142 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
13 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 54m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~10 min detour
Free
near mile 166.7
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This trip is a highway-focused drive, with 84% of your travel time spent on major thoroughfares. You will rely primarily on US 49, US 49W, and Medgar Evers Boulevard to navigate the interior of the state. Expect a steady pace, as the longest uninterrupted stretch covers 140.6 miles on US 49, requiring you to settle in for a significant portion of the trip. The road personality leans toward functional and efficient rather than technical, prioritizing direct transit over winding or scenic detours. As you move from the coastal region toward Greenville, you will find that the infrastructure remains consistent, allowing you to maintain a reliable rhythm throughout the day.
84% highway — fuel and pacing are the main things to plan.
33 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 140.6 mi on US 49.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 5.8 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 23 significant decision points across 284.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 5.8 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 6 miles: Highway fork - watch signs carefully; at 6.2 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
424 ft21 ft
Total Climb
655 ft
Total Descent
550 ft
Highest Point
424 ft
~118.5 mi in
Elevation Range
403 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Ocean Springs, MS and City of Greenville, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Jackson
27 mi in|~34m
Yazoo City
164.1 mi in|~3h 24m|via I 20; US 49
Vicksburg
211.8 mi in|~4h 23m|via US 49W
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 54m. Total distance: 284.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 54m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (84%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 140.6 miles on US 49. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at City of Greenville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 5.8 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 6 miles: Highway fork - watch signs carefully; at 6.2 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.9 hours each way, a round trip means 11.8 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at City of Greenville, MS before the return drive.
