Spanning 211.1 miles across Mississippi, this journey from Greenville to Meridian takes roughly 4 hours and 10 minutes. Because of the manageable duration, you can easily complete this trip in a single day without needing an overnight stay. Expect to spend about $32 on fuel, making it a budget-friendly transit through the Southeast. You will navigate a mix of local roads like North Martin Luther King Drive and Jerry Clower Boulevard before merging onto the interstate. Whether you are traveling for business or a change of scenery, the straightforward nature of this drive makes it a practical choice for a quick regional excursion.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
105.5 miles from City of Greenville, MS
A natural place for your longest stop of the day
, about 2h 11m into the drive
.
Main Roads
Road
Distance
Duration
I 20
88 mi
1h 35m
North Martin Luther King Drive
46.2 mi
55m
Jerry Clower Boulevard
38.8 mi
47m
US 82
15.8 mi
19m
US 49
8.7 mi
10m
MS 182
8.3 mi
12m
8th Street
1.4 mi
2m
US 11
1.2 mi
1m
Longest stretch:
I 20
— 88 mi, about 1h 35m
Turn-by-Turn Driving Directions
Step-by-step road directions between City of Greenville, MS and Meridian, MS.
1
Start on Sandy Avenue
46 ft·3 sec·Sandy Avenue
2
Turn right onto East Reed Road
0.7 mi·1 min·East Reed Road
3
Turn left onto MS 1
1.0 mi·1 min·Martin Luther King Junior Boulevard
4
Continue on MS 182
8.3 mi·12 min·MS 182
5
Turn left onto US 82; US 278
16 mi·19 min·US 82; US 278
Use the straight lane.
6
Turn right onto US 49W
46 mi·55 min·North Martin Luther King Drive
7
Keep slight right at fork onto US 49W
0.5 mi·53 sec·US 49W
Toward US 49 South: Jackson
8
Merge onto US 49
39 mi·47 min·Jerry Clower Boulevard
9
Take the exit onto US 49
4.9 mi·5 min·US 49
10
Keep slight left at fork onto US 49
3.8 mi·5 min·US 49
11
Merge onto I 20; I 55; US 49
1.1 mi·1 min·I 20; I 55; US 49
12
Keep slight right at fork onto I 20; US 49
85 mi·1 hr 32 min·I 20; US 49
Toward Meridian, Hattiesburg
13
Continue on I 20; I 59; US 80
1.4 mi·1 min·I 20; I 59; US 80
14
Take the exit
0.4 mi·44 sec
Toward South US 11, North Mississippi 19: Philadelphia, Meridian AirportUse the straight / slight right lanes.
15
Turn left onto US 11
1.2 mi·1 min·US 11
16
Turn right onto 8th Street
1.4 mi·2 min·8th Street
17
Turn right onto 25th Avenue
272 ft·11 sec·25th Avenue
18
Arrive at destination
25th Avenue
Trip Plan
To make the most of your 4-hour and 10-minute transit, aim for an early morning departure to avoid potential congestion on local routes. Since the itinerary includes one recommended stop, plan to take your break during the transition between the local road segments and the long I-20 stretch. Keep in mind that the 88-mile portion on the interstate is your longest period behind the wheel, so ensure your vehicle is fueled up before you merge. Because the drive is relatively short, you have plenty of flexibility to adjust your pace or take a longer rest if needed. Use the $32 fuel estimate as a baseline for your travel budget, and keep an eye on your tank levels as you enter the longer interstate sections.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 105.5 miles from City of Greenville, MS, or about 2h 11m into the drive.
The longest continuous stretch on this route runs about 88 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 46 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 105.5 miles or 2h 11m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 27m
Traffic, exits, and arrival timing usually matter more near Meridian, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving City of Greenville, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from City of Greenville, MS
This is one driving day of about 211.1 miles and 4h 10m.
Your first comfortable stop window is around 46 miles from City of Greenville, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 20 for about 88 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 12
5 decision points cluster between mile 10 and 208 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
10 mi into trip|~15m in|US 82; US 278
Turn left onto US 82; US 278
Lane positioning matters here
Use the straight lane.
5
72 mi into trip|~1h 30m in|US 49W
Keep slight right at fork onto US 49W toward US 49 South: Jackson
Highway fork - watch signs carefully
Toward US 49 South: Jackson
4
116.2 mi into trip|~2h 24m in|US 49
Keep slight left at fork onto US 49
Highway fork - watch signs carefully
6
121.1 mi into trip|~2h 31m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Meridian, Hattiesburg
7
208 mi into trip|~4h 5m in
Take the exit toward South US 11, North Mississippi 19: Philadelphia, Meridian Airport
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward South US 11, North Mississippi 19: Phila...
Fuel & Cost
Regular Gas
$31.88 one way
$63.76 round trip
$3.84/gal25.4 MPG avg74 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$35.00
$70.00
premium
$4.56
$37.89
$75.78
diesel
$5.61
$46.61
$93.22
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$32
Meals
$25–$50
Total
$57–$82
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 73.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $22 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
63.3
0
$22.17
$10.13
Efficient EV
52.8
0
$18.47
$8.44
EV Truck/SUV
84.4
1
$29.55
$13.51
Gas CO2
74 kg
EV CO2
25 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
City of Greenville, MS
Night
in City of Greenville on Saturday
Local time
11:51 PM
CDT
Current temp
80°F
Unavailable
Live forecast
Destination
Meridian, MS
Night
in Meridian on Saturday
Local time
11:51 PM
CDT
Current temp
79°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 10m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~10 min detour
Free
near mile 116.5
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This trip offers a mixed driving profile, transitioning from local surface streets to high-speed interstate travel. With a 58% highway share, you will spend a significant portion of your time cruising at higher speeds. The most substantial segment of your journey occurs on I-20, where you will face an 88-mile uninterrupted stretch. While the local roads provide a slower start to your trip, the transition to the interstate allows you to cover the remaining distance efficiently. You should prepare for a shift in pace as you move off the local boulevards and settle into the rhythm of the highway.
58% highway, the rest on surface roads — varied driving throughout.
18 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88 mi on I 20.
How Hard Is This Drive?
6/10
This route mixes highway mileage with some local-road sections near the start or finish. You will hit about 12 points where you need to pay attention to lane position or signs. The trickiest moment comes around 10 miles in near US 82; US 278.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 211.1 miles you will encounter 12 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 10 miles (US 82; US 278): Lane positioning matters here; at 72 miles (US 49W): Highway fork - watch signs carefully; at 116.2 miles (US 49): Highway fork - watch signs carefully.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from City of Greenville, MS to Meridian, MS, road signs begin pointing toward Hattiesburg along the way.
Hattiesburg
121.1 mi in|~2h 31m|via I 20; US 49
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 10m. Total distance: 211.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 10m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 88 miles on I 20. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Meridian, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 10 miles (US 82; US 278): Lane positioning matters here; at 72 miles (US 49W): Highway fork - watch signs carefully; at 116.2 miles (US 49): Highway fork - watch signs carefully.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.2 hours each way, an in-and-out day trip would put you behind the wheel for 8.3 hours — manageable with a long break at Meridian, MS, but most travelers stay overnight.
