City of Greenville, MS to Ripley, MS is 210.4 miles and takes about 4h 18m via US 61 and I 22, with a fuel budget near $32 and enough daylight to finish in a day. This drive stays within Mississippi, crossing from the Southeast region to another part of the Southeast. It's a straightforward, mostly highway trip that gets you from point A to point B efficiently. With a recommended one-day drive, you have plenty of flexibility to start your morning and still arrive with time to spare.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
105.2 miles from City of Greenville, MS
A natural place for your longest stop of the day
, about 2h 10m into the drive
.
Main Roads
Road
Distance
Duration
US 61
85.4 mi
1h 42m
I 22
35.6 mi
38m
MS 304
28.9 mi
31m
US 49
28.5 mi
32m
Mississippi Highway 2
9.6 mi
16m
MS 182
7.8 mi
11m
South Guyton Boulevard
6 mi
9m
South Broad Street
1.4 mi
2m
Longest stretch:
US 61
— 85.4 mi, about 1h 42m
Traffic on I-22
Hour-of-day weekday pattern from 4 FHWA count stations on your route.
Peak
4 PM
~1,155 veh/hr typical
· worst 1,377
Quietest
2 AM
~140 veh/hr
Peak-to-quiet ratio
8.3×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 46 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between City of Greenville, MS and Ripley, MS.
1
Start on Sandy Avenue
46 ft·3 sec·Sandy Avenue
2
Turn right onto East Reed Road
0.7 mi·1 min·East Reed Road
3
Turn left onto MS 1
1.0 mi·1 min·Martin Luther King Junior Boulevard
4
Continue on MS 182
7.8 mi·11 min·MS 182
5
Turn left onto South Broad Street
1.4 mi·2 min·South Broad Street
6
Turn straight onto Old Hwy 61
0.8 mi·1 min·Old Hwy 61
7
At end of road, turn right onto Griffin Road
145 ft·2 sec·Griffin Road
8
Turn left onto US 61; US 278
68 mi·1 hr 22 min·US 61; US 278
9
Continue on US 49; US 61
29 mi·32 min·US 49; US 61
10
Continue on US 61; MS 4
17 mi·20 min·US 61; MS 4
11
Take the exit
0.3 mi·44 sec
Toward MS 304 East: Memphis, Hernando
12
Continue on MS 304
29 mi·31 min·MS 304
13
Take the exit
0.4 mi·30 sec
Toward I 22, US 78: Memphis, TupeloUse the straight / slight right lanes.
14
Keep slight right at fork
1.0 mi·1 min
Toward I 22 East, US 78 East: Holly Springs, Tupelo
15
Merge onto I 22; US 78
36 mi·38 min·I 22; US 78
16
Take the exit
0.2 mi·31 sec
Toward MS 178: Hickory Flat
17
Keep slight left at fork
300 ft·10 sec
18
Turn left onto MS 178
0.3 mi·30 sec·MS 178
19
Continue on MS 178
0.8 mi·1 min·MS 178
20
Turn left onto MS 5
0.3 mi·33 sec·MS 5
21
Turn right onto MS 2
0.9 mi·1 min·Mississippi Highway 2
22
Continue on MS 2
8.8 mi·15 min·Mississippi Highway 2
23
Continue on MS 2
0.6 mi·1 min·West Palmer Street
24
Turn left onto MS 15
6.0 mi·9 min·South Guyton Boulevard
25
Turn left onto South Main Street
0.4 mi·1 min·South Main Street
26
Turn left onto West Walnut Street
457 ft·20 sec·West Walnut Street
27
Arrive at destination
West Walnut Street
Trip Plan
Given the 4h 18m estimated drive time, leaving City of Greenville, MS in the morning is ideal to maximize daylight. You'll want to plan for at least one stop to break up the 210.4 miles; the recommended stop count is 1. Keep an eye on your fuel gauge, especially during the 85.4-mile stretch on US 61, as services might be more spaced out. The $32 fuel cost is an estimate, so it's wise to check current prices. This route is well-suited for a single-day trip, so you don't need to worry about overnight accommodations unless you plan to extend your stay in Ripley.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 105.2 miles from City of Greenville, MS, or about 2h 10m into the drive.
The longest continuous stretch on this route runs about 85.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 46 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 105.2 miles or 2h 10m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 25m
Traffic, exits, and arrival timing usually matter more near Ripley, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving City of Greenville, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from City of Greenville, MS
This is one driving day of about 210.4 miles and 4h 18m.
Your first comfortable stop window is around 46 miles from City of Greenville, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 61 for about 85.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 11.7 and 192.1 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
11.7 mi into trip|~18m in|Griffin Road
At end of road, turn right onto Griffin Road
Navigation decision point
5
125.6 mi into trip|~2h 34m in
Take the exit toward MS 304 East: Memphis, Hernando
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward MS 304 East: Memphis, Hernando
7
154.9 mi into trip|~3h 6m in
Take the exit toward I 22, US 78: Memphis, Tupelo
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 22, US 78: Memphis, Tupelo
6
155.3 mi into trip|~3h 6m in
Keep slight right at fork toward I 22 East, US 78 East: Holly Springs, Tupelo
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 22 East, US 78 East: Holly Springs, Tu...
5
192.1 mi into trip|~3h 46m in
Keep slight left at fork
Highway fork - watch signs carefully
Fuel & Cost
Regular Gas
$29.21 one way
$58.41 round trip
$3.53/gal25.4 MPG avg74 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$3.95
$32.68
$65.36
premium
$4.29
$35.53
$71.06
diesel
$4.80
$39.73
$79.45
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$29
Meals
$25–$50
Total
$54–$79
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 73.6 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $22 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
63.1
0
$22.09
$10.10
Efficient EV
52.6
0
$18.41
$8.42
EV Truck/SUV
84.2
1
$29.46
$13.47
Gas CO2
74 kg
EV CO2
25 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 19, 2026
Origin
City of Greenville, MS
Late night
in City of Greenville on Sunday
Local time
2:07 AM
CDT
Current temp
76°F
Mostly Clear
WSW 0 to 5 mph3% chanceLive forecast
Heat Advisory
Heat Advisory issued July 18 at 1:23PM CDT until July 19 at 7:00PM CDT by NWS Mobile AL
Heat Advisory
Heat Advisory issued July 18 at 12:07PM CDT until July 18 at 8:00PM CDT by NWS Memphis TN
Destination
Ripley, MS
Late night
in Ripley on Sunday
Local time
2:07 AM
CDT
Current temp
75°F
Mostly Clear
W 0 to 5 mph2% chanceLive forecast
Heat Advisory
Heat Advisory issued July 18 at 1:23PM CDT until July 19 at 7:00PM CDT by NWS Mobile AL
Heat Advisory
Heat Advisory issued July 18 at 12:07PM CDT until July 18 at 8:00PM CDT by NWS Memphis TN
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 18m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
17 mi from route
~43 min detour
Free
near mile 72.5
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
30 mi from route
~75 min detour
Free
near mile 203.1
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
You'll be on highways for about 94% of this 210.4-mile trip. The longest continuous stretch on a single highway is 85.4 miles on US 61. Expect the transition from US 61 to I 22 and MS 304 to feel like a significant shift in the driving environment as you move onto higher-speed interstate travel. The extensive highway usage means you'll encounter fewer local intersections and more on- and off-ramps.
94% highway — fuel and pacing are the main things to plan.
27 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 85.4 mi on US 61.
How Hard Is This Drive?
5/10
This is a straightforward highway drive that stays mostly on US 61 and I 22. You will hit about 15 points where you need to pay attention to lane position or signs. The trickiest moment comes around 11.7 miles in near Griffin Road.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 210.4 miles you will encounter 15 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 11.7 miles (Griffin Road): Navigation decision point; at 125.6 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 154.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
519 ft121 ft
Total Climb
399 ft
Total Descent
38 ft
Highest Point
519 ft
~195.3 mi in
Elevation Range
399 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between City of Greenville, MS and Ripley, MS, road signs point toward Hernando and Tupelo.
Doable as a same-day drive at 4h 18m. Total distance: 210.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 18m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (94%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 85.4 miles on US 61. The full list of main roads is in the Roads section above.
Yes — we found about 4 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: at 11.7 miles (Griffin Road): Navigation decision point; at 125.6 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 154.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Emmett Till and Mamie Till-Mobley National Monument and Natchez Trace National Scenic Trail. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.3 hours each way, an in-and-out day trip would put you behind the wheel for 8.6 hours — manageable with a long break at Ripley, MS, but most travelers stay overnight.
