Embark on a 301.6-mile journey from Moss Point, MS, to the City of Greenville, MS, a trip that will take approximately 6 hours and 12 minutes. Primarily following US 49 and its variations like US 49W, this route is a solid option for a single-day adventure, especially given its manageable duration. You can expect a fuel cost of around $46 for this drive. The majority of this trip is on highways, offering a straightforward travel experience across Mississippi. This route keeps you within the Southeast region, providing a consistent regional feel throughout your drive.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
150.8 miles from Moss Point, MS
A natural place for your longest stop of the day
, about 3h 3m into the drive
.
Main Roads
Road
Distance
Duration
US 49
140.6 mi
2h 53m
US 49W
46.7 mi
56m
Medgar Evers Boulevard
39.5 mi
48m
I 10
20.6 mi
22m
Biloxi-D'Iberville Scenic Expressway
20.4 mi
23m
US 82
15.8 mi
19m
MS 182
8.3 mi
12m
I 20
4.3 mi
5m
Longest stretch:
US 49
— 140.6 mi, about 2h 53m
Turn-by-Turn Driving Directions
Step-by-step road directions between Moss Point, MS and City of Greenville, MS.
1
Start on this road
64 ft·6 sec·this road
2
Turn right onto Mc Innis Avenue
0.3 mi·44 sec·Mc Innis Avenue
3
At end of road, turn right onto MS 613
1.9 mi·3 min·Main Street
4
Take the ramp
135 ft·7 sec
5
Turn left
0.3 mi·33 sec
6
Merge onto I 10
21 mi·22 min·I 10
7
Take the exit
0.2 mi·20 sec
Exit 46D-BToward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
8
Keep slight left at fork
0.2 mi·23 sec
9
Keep slight right at fork
0.4 mi·46 sec
Exit 46CToward MS 15, MS 67: MS 15, MS 67
10
Merge onto MS 15; MS 67
20 mi·23 min·Biloxi-D'Iberville Scenic Expressway
Use the straight lane.
11
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
12
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
13
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
14
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
15
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
16
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
17
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
18
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
19
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
20
Take the exit onto US 49
0.2 mi·21 sec·US 49
21
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
22
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
23
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
24
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
25
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
26
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
27
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
28
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
29
Turn left onto US 82
2.4 mi·3 min·US 82
30
Keep slight left at fork onto US 82
0.4 mi·29 sec·US 82
31
Keep slight left at fork onto US 82
13 mi·15 min·US 82
32
Turn right onto MS 182
8.3 mi·12 min·MS 182
33
Turn left onto MS 1
1.0 mi·1 min·Martin Luther King Junior Boulevard
34
Turn right onto East Reed Road
0.7 mi·1 min·East Reed Road
35
Turn left onto Sandy Avenue
46 ft·2 sec·Sandy Avenue
36
Arrive at destination
Sandy Avenue
Trip Plan
With a 6-hour drive time, starting your trip from Moss Point in the morning allows ample time to reach Greenville without feeling rushed. Plan for one main stop to break up the 301.6 miles, perhaps midway through the longest stretch on US 49. Given the $46 fuel cost, ensure your tank is full before departing to avoid unnecessary detours for gas. The flexibility of a single-day trip means you can adapt to traffic or take brief breaks as needed, but keep an eye on the time to ensure a comfortable arrival.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 150.8 miles from Moss Point, MS, or about 3h 3m into the drive.
The longest continuous stretch on this route runs about 140.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 66 miles or 1h 17m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 150.8 miles or 3h 3m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 2m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Moss Point, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Moss Point, MS
This is one driving day of about 301.6 miles and 6h 12m.
Your first comfortable stop window is around 66 miles from Moss Point, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 140.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 25
5 decision points cluster between mile 0.3 and 181.4 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0.3 mi into trip|~0m in|MS 613 / Main Street
At end of road, turn right onto MS 613 / Main Street
Navigation decision point
6
23.1 mi into trip|~26m in
Take the exit toward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 46D-B
Toward I 110, MS 15, MS 67: Biloxi, Keesler Air...
7
23.4 mi into trip|~27m in
Keep slight right at fork toward MS 15, MS 67: MS 15, MS 67
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 46C
Toward MS 15, MS 67: MS 15, MS 67
6
44.2 mi into trip|~52m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
6
181.4 mi into trip|~3h 41m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
Fuel & Cost
Regular Gas
$45.55 one way
$91.10 round trip
$3.84/gal25.4 MPG avg106 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$50.00
$100.00
premium
$4.56
$54.13
$108.27
diesel
$5.61
$66.59
$133.18
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$46
Meals
$25–$50
Total
$71–$96
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 105.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $32 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
90.5
1
$31.67
$14.48
Efficient EV
75.4
0
$26.39
$12.06
EV Truck/SUV
120.6
1
$42.22
$19.30
Gas CO2
106 kg
EV CO2
35 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Moss Point, MS
Evening
in Moss Point on Saturday
Local time
8:31 PM
CDT
Current temp
57°F
Unavailable
Live forecast
Destination
City of Greenville, MS
Evening
in City of Greenville on Saturday
Local time
8:31 PM
CDT
Current temp
80°F
Unavailable
Live forecast
55°F
Florence, MS
151 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
23 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 12m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
2 mi from route
~5 min detour
Free
near mile 187.2
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This drive offers a highway-focused experience, with 85% of the route utilizing major roadways. Expect a relatively consistent pace, punctuated by a significant stretch of 140.6 miles on US 49 without needing to divert. While largely on the highway, you'll navigate through various road types as you progress, including Medgar Evers Boulevard closer to your destination. The character is less about winding scenic byways and more about efficient travel across the state.
85% highway — fuel and pacing are the main things to plan.
36 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 140.6 mi on US 49.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.3 miles in near MS 613 / Main Street.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 25 significant decision points across 301.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.3 miles (MS 613 / Main Street): Navigation decision point; at 23.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 23.4 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Moss Point, MS and City of Greenville, MS, road signs point toward Keesler Air Force Base, Jackson, Yazoo City and Vicksburg.
Keesler Air Force Base
23.1 mi in|~26m
Jackson
44.2 mi in|~52m
Yazoo City
181.4 mi in|~3h 41m|via I 20; US 49
Vicksburg
229.1 mi in|~4h 40m|via US 49W
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 12m. Total distance: 301.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 12m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 140.6 miles on US 49. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at City of Greenville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 0.3 miles (MS 613 / Main Street): Navigation decision point; at 23.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 23.4 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.2 hours each way, a round trip means 12.4 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at City of Greenville, MS before the return drive.
