Traveling from Moss Point to Southaven covers 376.6 miles across the state of Mississippi, a journey that typically takes about 7 hours and 14 minutes. Because this route is almost entirely highway-focused, you can comfortably complete the drive in a single day, though it will be a substantial time commitment behind the wheel. Expect to budget approximately $58 for fuel to make the trip. You will traverse the Southeast region from the coast toward the northern border, transitioning from the Gulf area to the Memphis metropolitan vicinity. It is a straightforward, practical transit route that works well if you are looking to get from point A to point B efficiently without unnecessary detours.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
188.3 miles from Moss Point, MS
A natural place for your longest stop of the day
, about 3h 48m into the drive
.
Main Roads
Road
Distance
Duration
I 55
195.7 mi
3h 31m
US 49
135 mi
2h 46m
I 10
20.6 mi
22m
Biloxi-D'Iberville Scenic Expressway
20.4 mi
23m
Main Street
1.9 mi
3m
Stateline Road West
0.4 mi
<1m
Mc Innis Avenue
0.3 mi
<1m
Millbranch Road
0.2 mi
<1m
Longest stretch:
I 55
— 195.7 mi, about 3h 31m
Turn-by-Turn Driving Directions
Step-by-step road directions between Moss Point, MS and Southaven, MS.
1
Start on this road
64 ft·6 sec·this road
2
Turn right onto Mc Innis Avenue
0.3 mi·44 sec·Mc Innis Avenue
3
At end of road, turn right onto MS 613
1.9 mi·3 min·Main Street
4
Take the ramp
135 ft·7 sec
5
Turn left
0.3 mi·33 sec
6
Merge onto I 10
21 mi·22 min·I 10
7
Take the exit
0.2 mi·20 sec
Exit 46D-BToward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
8
Keep slight left at fork
0.2 mi·23 sec
9
Keep slight right at fork
0.4 mi·46 sec
Exit 46CToward MS 15, MS 67: MS 15, MS 67
10
Merge onto MS 15; MS 67
20 mi·23 min·Biloxi-D'Iberville Scenic Expressway
Use the straight lane.
11
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
12
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
13
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
14
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
15
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
16
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
17
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
18
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
19
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
20
Take the exit onto US 49
0.2 mi·21 sec·US 49
21
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
22
Keep slight right at fork onto US 49
0.9 mi·1 min·US 49
23
Merge onto I 55
196 mi·3 hr 31 min·I 55
24
Take the exit
0.3 mi·43 sec
Toward Southaven, Horn Lake
25
Turn left onto Stateline Road West
0.4 mi·53 sec·Stateline Road West
26
Turn left onto Millbranch Road
0.2 mi·36 sec·Millbranch Road
27
Turn right onto Haleville Drive
0.2 mi·53 sec·Haleville Drive
28
Turn left onto Five Oaks Drive North
0.1 mi·28 sec·Five Oaks Drive North
29
Arrive at destination
Five Oaks Drive West
Trip Plan
To manage the 7-hour and 14-minute duration effectively, plan for at least two intentional stops to stretch your legs and refuel. Since the drive is heavily reliant on I-55, keep an eye on traffic reports for the Memphis area as you approach Southaven, as congestion can fluctuate. Departing early in the morning is your best bet to avoid peak traffic and ensure you reach your destination before fatigue sets in. Because the route is highway-dominated, keep your cruise control ready for the long 195.7-mile stretch on I-55 to maintain a steady speed. Staying flexible with your timing will help you navigate the transition from the coastal region to the northern part of the state with ease.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 188.3 miles from Moss Point, MS, or about 3h 48m into the drive.
The longest continuous stretch on this route runs about 195.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 83 miles or 1h 37m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 188.3 miles or 3h 48m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 6h 7m
Traffic, exits, and arrival timing usually matter more near Southaven, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Moss Point, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
Day 1
Settle into the route from Moss Point, MS
This is one driving day of about 376.6 miles and 7h 14m.
Your first comfortable stop window is around 83 miles from Moss Point, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on I 55 for about 195.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 0.3 and 44.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0.3 mi into trip|~0m in|MS 613 / Main Street
At end of road, turn right onto MS 613 / Main Street
Navigation decision point
6
23.1 mi into trip|~26m in
Take the exit toward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 46D-B
Toward I 110, MS 15, MS 67: Biloxi, Keesler Air...
5
23.3 mi into trip|~27m in
Keep slight left at fork
Highway fork - watch signs carefully
7
23.4 mi into trip|~27m in
Keep slight right at fork toward MS 15, MS 67: MS 15, MS 67
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 46C
Toward MS 15, MS 67: MS 15, MS 67
6
44.2 mi into trip|~52m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
Fuel & Cost
Regular Gas
$56.88 one way
$113.75 round trip
$3.84/gal25.4 MPG avg132 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$62.44
$124.87
premium
$4.56
$67.60
$135.19
diesel
$5.61
$83.15
$166.30
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$57
Meals
$25–$50
Total
$82–$107
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 131.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $40 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
113
1
$39.54
$18.08
Efficient EV
94.2
1
$32.95
$15.06
EV Truck/SUV
150.6
1
$52.72
$24.10
Gas CO2
132 kg
EV CO2
44 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Moss Point, MS
Evening
in Moss Point on Saturday
Local time
8:24 PM
CDT
Current temp
57°F
Unavailable
Live forecast
Destination
Southaven, MS
Evening
in Southaven on Saturday
Local time
8:24 PM
CDT
Current temp
56°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
7h 14m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
With 99% of your time spent on highways, this trip is defined by a consistent, high-speed pace rather than winding backroads. You will navigate a combination of I-10, US-49, and I-55 to complete your journey. The most significant portion of the drive is a 195.7-mile stretch on I-55, which serves as the primary artery for the latter half of your trip. You should expect a classic interstate experience characterized by steady cruising and limited technical driving. This configuration makes for a predictable ride, allowing you to cover the distance quickly while staying almost exclusively on major thoroughfares.
99% highway — fuel and pacing are the main things to plan.
29 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 195.7 mi on I 55.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on I 55 and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.3 miles in near MS 613 / Main Street.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 376.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.3 miles (MS 613 / Main Street): Navigation decision point; at 23.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 23.3 miles: Highway fork - watch signs carefully.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Moss Point, MS and Southaven, MS, road signs point toward Keesler Air Force Base and Jackson.
Keesler Air Force Base
23.1 mi in|~26m
Jackson
44.2 mi in|~52m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 7h 14m. Total distance: 376.6 miles.
Family Friendly
Moderate complexity with 2 natural rest stops along the way.
Solo Traveler
7h 14m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 195.7 miles on I 55. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Southaven, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 0.3 miles (MS 613 / Main Street): Navigation decision point; at 23.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 23.3 miles: Highway fork - watch signs carefully.
Not recommended in a single day. At 7.2 hours each way, a round trip means 14.5 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Southaven, MS before the return drive.
