Origin
Picayune, MS
Late night in Picayune on Tuesday
Local time
3:47 AM
CDT
Current temp
84°F
Unavailable
Live forecast
Trip from Picayune, MS to Biloxi, MS
Pin this tripCompiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Apr 21, 2026 · Editorial standards
Drive Time
1h 22m
Distance
65.2 mi
105 km
Drive Score
7/10
Good drive
Same Day?
Yes, doable
Fuel Cost
$10
one way
EV Charging
Good
8 stations
Best Time to Leave
4 AM
1h 16m
★
6 AM
1h 23m
8 AM
1h 35m
10 AM
1h 27m
12 PM
1h 26m
3 PM
1h 28m
5 PM
1h 35m
8 PM
1h 19m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Picayune, MS
Wikimedia Commons
Biloxi, MS
Wikimedia Commons
Trip Overview
If you are planning a quick transition from Picayune to the Mississippi Gulf Coast, this 65.2-mile journey is a straightforward trek across the southeastern corner of the state. You can expect a drive time of roughly 1 hour and 22 minutes, making it a perfect candidate for a single-day trip. With a fuel budget of approximately $10, it is an economical route that requires minimal logistical planning. Since both cities are located within the same region, you won't experience drastic climate or time zone shifts. This trip is ideal for those who prefer a direct, no-fuss connection between inland Mississippi and the coast. It is efficient enough that you can easily head out in the morning and arrive in Biloxi with plenty of time to spare.
Main Roads
| Road | Distance | Duration |
|---|---|---|
| I 10 | 42.8 mi | 45m |
| Shuttle Parkway | 6.8 mi | 12m |
| State Highway 607 | 5.7 mi | 6m |
| US 11 | 4.1 mi | 6m |
| I 110 | 2.7 mi | 3m |
| Division Street | 0.6 mi | 1m |
| Main Street | 0.5 mi | 1m |
| MS 607 | 0.2 mi | <1m |
Longest stretch:
I 10
— 42.8 mi, about 45m
Turn-by-Turn Driving Directions
Step-by-step road directions between Picayune, MS and Biloxi, MS.
1
Start on East Canal Street
0.1 mi
·
24 sec
·
East Canal Street
2
Turn left onto US 11
4.1 mi
·
6 min
·
US 11
3
Continue on State Highway 607
5.7 mi
·
6 min
·
State Highway 607
4
Continue on Shuttle Parkway
6.8 mi
·
12 min
·
Shuttle Parkway
5
Continue on MS 607
0.2 mi
·
22 sec
·
MS 607
6
Turn left
0.3 mi
·
36 sec
7
Merge onto I 10
43 mi
·
45 min
·
I 10
8
Take the exit
0.1 mi
·
14 sec
Exit 46A-C
Toward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
9
Keep slight left at fork
0.4 mi
·
51 sec
10
Keep slight right at fork
0.5 mi
·
1 min
Exit 46B
Toward I 110: Biloxi, Keesler Air Force Base
11
Merge onto I 110
2.7 mi
·
3 min
·
I 110
12
Take the exit
0.4 mi
·
47 sec
Exit 1c
Toward Division Street
13
Turn left onto Division Street
0.6 mi
·
1 min
·
Division Street
14
Turn right onto Main Street
0.5 mi
·
1 min
·
Main Street
15
Turn left onto Howard Avenue
91 ft
·
3 sec
·
Howard Avenue
16
Arrive at destination
Howard Avenue
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Mid-route town
Meal stop
33 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 14 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 32.6 miles from Picayune, MS, which is a good place for a longer meal and fuel stop.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Heads-up: tricky spots
5 of 105 decision points cluster between mile 16.9 and 63.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
16.9 mi into trip
|
~26m in
Turn left
Navigation decision point
6
60 mi into trip
|
~1h 12m in
Take the exit toward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 46A-C
Toward I 110, MS 15, MS 67: Biloxi, Keesler Air...
4
60.1 mi into trip
|
~1h 12m in
Keep slight left at fork
Highway fork - watch signs carefully
7
60.5 mi into trip
|
~1h 13m in
Keep slight right at fork toward I 110: Biloxi, Keesler Air Force Base
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 46B
Toward I 110: Biloxi, Keesler Air Force Base
5
63.7 mi into trip
|
~1h 18m in
Take the exit toward Division Street
Exit ramp - move to the correct lane early
Exit 1c
Toward Division Street
Fuel & Cost
Regular Gas
$9.85 one way
$19.69 round trip
$3.84/gal
25.4 MPG avg
23 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.21 | $10.81 | $21.62 |
| premium | $4.56 | $11.70 | $23.41 |
| diesel | $5.61 | $14.40 | $28.79 |
No toll roads detected on this route.
Drive Cost (one way)
Fuel
$10
Estimated CO2 emission: 22.8 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $7 in charging · 0 stops · 65% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 19.6 | 0 | $6.85 | $3.13 |
| Efficient EV | 16.3 | 0 | $5.71 | $2.61 |
| EV Truck/SUV | 26.1 | 0 | $9.13 | $4.17 |
Gas CO2
23 kg
EV CO2
8 kg (65% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Biloxi, MS
Late night in Biloxi on Tuesday
Local time
3:47 AM
CDT
Current temp
78°F
Unavailable
Live forecast
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
6 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
1h 22m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
What kind of drive is this?
Expect a very focused, highway-heavy experience as you navigate this 65.2-mile route. With 96% of the journey spent on high-speed roads, you will rely heavily on I-10, State Highway 607, and Shuttle Parkway to cover ground quickly. You will spend a significant portion of your time on the interstate, including a longest uninterrupted stretch of 42.8 miles on I-10. Because this is a highway-focused drive, the pace remains consistent from start to finish. You won't find many technical turns or winding local backroads here; instead, anticipate a steady, predictable flow that prioritizes speed and efficiency over scenic detours.
96% highway — fuel and pacing are the main things to plan.
16 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 42.8 mi on I 10.
How Hard Is This Drive?
6/10
This is a straightforward highway drive that stays mostly on I 10 and Shuttle Parkway. You will hit about 10 points where you need to pay attention to lane position or signs. The trickiest moment comes around 16.9 miles in.
Driving Effort
6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 65.2 miles you will encounter 10 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 16.9 miles: Navigation decision point; at 60 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 60.1 miles: Highway fork - watch signs carefully.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Picayune, MS to Biloxi, MS, road signs begin pointing toward Keesler Air Force Base along the way.
Keesler Air Force Base
60 mi in
|
~1h 12m
About the Cities
Starting in Picayune, MS
Full guide →Picayune is a city in the Gulf Coast region of Mississippi.
Arriving in Biloxi, MS
Full guide →Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
City content from Wikivoyage (CC BY-SA 4.0) and Wikidata (CC0).
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 1h 22m. Total distance: 65.2 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
1h 22m drive, comfortable solo distance.
EV Driver
0 DC fast chargers along the route. Coverage: unknown.
First-Time Driver
Mostly highway driving (96%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 42.8 miles on I 10. The full list of main roads is in the Roads section above.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Biloxi, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Yes. At under 2 hours behind the wheel, this works well for families — plan one quick stop if you have younger kids.
The main spots that need attention: at 16.9 miles: Navigation decision point; at 60 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 60.1 miles: Highway fork - watch signs carefully.
Yes. A round trip is manageable in a single day if you plan a break at Biloxi, MS before heading back.
How this page is built
Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, and EIA for fuel prices. See our methodology for refresh cadence and limitations.
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