Skip to main content
US Trip Planner Logo
US Trip Planner

Trip from Picayune, MS to City of Greenville, MS

Compiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Apr 19, 2026 · Editorial standards

Drive Time

4h 32m

Distance

268.9 mi

433 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$41

one way

EV Charging

Sparse

1 stations

Best Time to Leave

Save up to 40 min
4 AM
4h 19m ★
6 AM
4h 32m
8 AM
4h 59m
10 AM
4h 42m
12 PM
4h 39m
3 PM
4h 43m
5 PM
4h 58m
8 PM
4h 24m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly
Google Maps Waze Apple Maps
Download GPX
city in Pearl River County, Mississippi, United States

Picayune, MS

Wikimedia Commons

Downtown City of Greenville, MS, MS

City of Greenville, MS

Alex Borelli

Trip Overview

Embarking from Picayune, Mississippi, your journey to the City of Greenville, Mississippi, covers 268.9 miles and is estimated to take about 4 hours and 32 minutes of driving time. This drive is easily manageable as a single-day trip, with a projected fuel cost of around $41. You'll primarily navigate via Highway 43 North and US 49 North, with a brief stretch on East Sycamore Road. The route offers a local driving experience, suggesting you'll encounter more turns and varied road conditions than a typical interstate cruise. Given both the origin and destination are within the Southeast region, expect a consistent regional feel throughout your travels.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

134.4 miles from Picayune, MS

A natural place for your longest stop of the day , about 2h 16m into the drive .

Main Roads

Road Distance Duration
Highway 43 North — —
East Sycamore Road — —
US 49 North — —
Jackson — —
I 20 West — —
I 220 North — —
Medgar Evers Boulevard — —
US 49W North — —

Some road-level metrics are being recalculated.

Longest stretch: Highway 43 North — detailed segment metrics are refreshing.

Turn-by-Turn Driving Directions

Step-by-step road directions between Picayune, MS and City of Greenville, MS.

1

Start on East Canal Street

0.1 mi · 22 sec · East Canal Street
2

Turn right

1.5 mi · 2 min
3

Turn right onto Highway 43 North

1.1 mi · 1 min · Highway 43 North
4

Continue on East Sycamore Road

0.2 mi · 20 sec · East Sycamore Road
5

Take the ramp left

0.2 mi · 34 sec
6

Merge slight left

61 mi · 1 hr 5 min
7

Take the exit slight right toward US 49 North, MS 42 West: Jackson

0.2 mi · 39 sec · US 49 North, MS 42 West: Jackson
8

Continue straight

1.2 mi · 1 min
9

Continue straight

5.4 mi · 6 min
10

Continue straight

5.3 mi · 6 min
11

Continue straight

0.2 mi · 14 sec
12

Continue straight

4.2 mi · 4 min
13

Continue straight

66 mi · 1 hr 20 min
14

Take the exit slight right

0.2 mi · 21 sec
15

Keep slight left to continue on Jackson

0.7 mi · 1 min · Jackson
16

Keep slight left

1.0 mi · 1 min
17

Merge slight right

1.6 mi · 2 min
18

Keep slight right to continue on I 20 West, US 49 North: Vicksburg, Yazoo City

2.7 mi · 3 min · I 20 West, US 49 North: Vicksburg, Yazoo City
19

Take the exit slight right toward I 220 North, I 49 North: North Jackson, Yazoo City

5.2 mi · 6 min · I 220 North, I 49 North: North Jackson, Yazoo City
20

Take the exit slight right toward US 49 North: Yazoo City

0.3 mi · 33 sec · US 49 North: Yazoo City
21

Merge slight left onto Medgar Evers Boulevard

39 mi · 48 min · Medgar Evers Boulevard
22

Take the exit slight right toward US 49W North, MS 3 South: Indianola, Vicksburg

47 mi · 56 min · US 49W North, MS 3 South: Indianola, Vicksburg
23

Turn left

2.4 mi · 3 min
24

Keep slight left

0.4 mi · 29 sec
25

Keep slight left

13 mi · 15 min
26

Turn right

8.3 mi · 12 min
27

Turn left onto Martin Luther King Junior Boulevard

1.0 mi · 1 min · Martin Luther King Junior Boulevard
28

Turn right onto East Reed Road

0.7 mi · 1 min · East Reed Road
29

Turn left onto Sandy Avenue

46 ft · 2 sec · Sandy Avenue
30

Arrive at your destination

Trip Plan

With a total drive time of just over 4.5 hours, this trip is best suited for a single day, allowing for flexibility in your departure time. Consider an early morning start to maximize your daylight hours and minimize potential traffic, especially as you navigate through local areas. With only one suggested stop, you have plenty of room to decide when and where to take breaks based on your comfort. Keep an eye on your fuel gauge, as the $41 estimated cost is based on the full 268.9 miles, and local roads can sometimes be less predictable for fuel availability. A practical tip for this 'turn-heavy' route is to ensure your navigation system is fully charged and updated before you depart.

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 134.4 miles from Picayune, MS, or about 2h 16m into the drive.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 59 miles or 59m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 134.4 miles or 2h 16m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 3h 43m

Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.

Before You Leave

+

Open the route before leaving Picayune, MS so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Picayune, MS

This is one driving day of about 268.9 miles and 4h 32m.

Your first comfortable stop window is around 59 miles from Picayune, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Mid-route town

Meal stop

Jackson, MS

134 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Magee, MS

Fuel and coffee

A short stop after about 59 miles helps settle the day before fatigue starts building.

Jackson, MS

Meal break

The midpoint is around 134.4 miles from Picayune, MS, which is a good place for a longer meal and fuel stop.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Nearby Places

Restaurants, cafes, gas stations and more along your route.

Top Restaurant

Jack's Family Restaurant

4.3 ★ ★ ★ ★ ☆

Yazoo City, Mississippi

Later in the drive, short detour

2.8 mi from route ~7 min detour $10 to $20 mile 192.1

Hours: 5 am–10 pm

+16626705402

Visit website

Jack's Family Restaurant

4.3 ★ ★ ★ ★ ☆

Later in the drive, short detour

2.8 mi from route ~7 min detour $10 to $20 mile 192.1

Yazoo City, Mississippi

Hours: 5 am–10 pm

+16626705402

Visit website

Bougie Coffee Company

4.8 ★ ★ ★ ★ ★

Around the midpoint, ~11 min detour

4.6 mi from route ~11 min detour $1 to $10 mile 134.4

Florence, Mississippi

Hours: 6 am–5 pm

+16017159972

Visit website

Roma Italian Restaurant

4.6 ★ ★ ★ ★ ★

Around the midpoint, ~11 min detour

4.6 mi from route ~11 min detour $20 to $30 mile 153.7

Clinton, Mississippi

Hours: 11 am–9 pm

+16014884850

Visit website

Coffee Prose Midtown

4.7 ★ ★ ★ ★ ★

Around the midpoint, ~9 min detour

3.8 mi from route ~9 min detour $1 to $10 mile 153.7

Jackson, Mississippi

Hours: 7 am–6 pm

+17692080230

Visit website

Urban Foxes

4.8 ★ ★ ★ ★ ★

Around the midpoint, ~10 min detour

4.1 mi from route ~10 min detour $1 to $10 mile 153.7

Jackson, Mississippi

Hours: 7:30 am–5:30 pm

+17695725505

Visit website

Soule' coffee + bubbletea

4.9 ★ ★ ★ ★ ★

Around the midpoint, ~11 min detour

4.5 mi from route ~11 min detour $1 to $10 mile 153.7

Jackson, Mississippi

Hours: 9 am–9 pm

Visit website

ViaLynk Charging Station

1.0 ★ ☆ ☆ ☆ ☆

Near the start, short detour

2.2 mi from route ~6 min detour

Carriere, Mississippi

Hours: Open 24 hours

Visit website

The Jackson Zoo

3.2 ★ ★ ★ ☆ ☆

Around the midpoint, short detour

1.5 mi from route ~4 min detour mile 153.7

Jackson, Mississippi

Hours: 10 am–4 pm

+16019528776

Visit website

Mississippi Museum of Art

4.7 ★ ★ ★ ★ ★

Around the midpoint, ~9 min detour

3.7 mi from route ~9 min detour mile 153.7

Jackson, Mississippi

Hours: 11 am–5 pm

+16019601515

Visit website

Time Will Tell Escape Games

5.0 ★ ★ ★ ★ ★

Early in the drive, ~10 min detour

4 mi from route ~10 min detour mile 57.6

Hattiesburg, Mississippi

Hours: 1:30–8:30 pm

+16018136951

Visit website

601 Escape Rooms

5.0 ★ ★ ★ ★ ★

Around the midpoint, ~10 min detour

4.1 mi from route ~10 min detour mile 153.7

Jackson, Mississippi

Hours: Closed

+16012603334

Visit website

Battlefield Park

4.0 ★ ★ ★ ★ ☆

Around the midpoint, short detour

3.3 mi from route ~8 min detour mile 153.7

Jackson, Mississippi

Hours: 8 am–7 pm

Visit website

Mississippi Civil Rights Museum

4.8 ★ ★ ★ ★ ★

Around the midpoint, ~10 min detour

4.1 mi from route ~10 min detour mile 153.7

Jackson, Mississippi

Hours: 9 am–5 pm

+16015766800

Visit website

Smith Robertson Museum

4.6 ★ ★ ★ ★ ★

Around the midpoint, ~9 min detour

3.5 mi from route ~9 min detour mile 153.7

Jackson, Mississippi

Hours: 9 am–5 pm

+16019601457

Visit website

Hattiesburg Zoo

4.6 ★ ★ ★ ★ ★

Early in the drive, ~10 min detour

4.1 mi from route ~10 min detour mile 57.6

Hattiesburg, Mississippi

Hours: 10 am–4 pm

+16015454576

Visit website

Place data sourced from public business listings. Hours and availability may vary.

Fuel & Cost

Regular Gas

$40.61 one way

$81.22 round trip

$3.84/gal 25.4 MPG avg 94 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.21 $44.58 $89.16
premium $4.56 $48.26 $96.53
diesel $5.61 $59.37 $118.74

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$41

Meals

$25–$50

Total

$66–$91

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 94.1 kg one way. Prices: EIA weekly data, 2026-04-13.

Driving Electric?

About $28 in charging · 0 stops · 67% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 80.7 0 $28.23 $12.91
Efficient EV 67.2 0 $23.53 $10.76
EV Truck/SUV 107.6 1 $37.65 $17.21

Gas CO2

94 kg

EV CO2

31 kg (67% less)

Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast as of Apr 15, 2026

Origin

Picayune, MS

Night in Picayune on Saturday

Local time

11:51 PM

CDT

Current temp

77°F

Unavailable

Live forecast

Destination

City of Greenville, MS

Night in City of Greenville on Saturday

Local time

11:51 PM

CDT

Current temp

80°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

3 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

4h 32m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

What kind of drive is this?

This route is characterized as a 'turn-heavy local drive,' meaning you won't be on a limited-access highway for the majority of your trip, as indicated by the 0% highway share. Expect a more engaging driving experience with frequent changes in direction and potentially slower speeds as you pass through various communities. While there isn't a specified longest uninterrupted stretch, the nature of this route suggests you'll be making regular adjustments to your course. The progression will likely involve a mix of state highways and local roads, requiring your attention to navigation.

Only 0% highway — the rest is turn-by-turn surface driving.
30 navigation steps total — most of the decisions cluster near the start and finish.
Main road: Highway 43 North.

How Hard Is This Drive?

3/10

Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way.

Driving Effort 3/10

Easy - simple navigation with a manageable amount of wheel time

Balances navigation complexity with total wheel time.

This is a straightforward 4h 32m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.

Where does it get tricky?

This route does not have any notably tricky sections. Most of the drive from Picayune, MS to City of Greenville, MS is straightforward, with well-signed roads and simple exits.

Who Is This Route For?

Weekend Trip

Doable as a same-day drive at 4h 32m. Total distance: 268.9 miles.

Family Friendly

Moderate complexity with 1 natural rest stops along the way.

Solo Traveler

4h 32m drive, comfortable solo distance.

First-Time Driver

Mostly highway driving (0%). Straightforward navigation.

Scenic Drive

Mostly surface roads route profile.

Frequently Asked Questions

We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.

Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.

This route does not have any notably tricky sections. Most of the drive from Picayune, MS to City of Greenville, MS is straightforward, with well-signed roads and simple exits.

Possible but tiring. At 4.5 hours each way, an in-and-out day trip would put you behind the wheel for 9.1 hours — manageable with a long break at City of Greenville, MS, but most travelers stay overnight.

How this page is built

Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, and EIA for fuel prices. See our methodology for refresh cadence and limitations.

Was this helpful?

Thanks for your feedback!

Your tip has been submitted. Thanks!

/500

Explore More

Continue From City of Greenville, MS

Meridian, MS 211.1 mi · 4h 10m Auburn, MS 192.8 mi · 4h 4m Tupelo, MS 186.2 mi · 4h 1m Byram, MS 127.2 mi · 2h 39m

More from Picayune, MS

Jackson, MS 150.3 mi · 2h 58m Meridian, MS 149.4 mi · 2h 44m Biloxi, MS 65.2 mi · 1h 22m

More trips to City of Greenville, MS

Pascagoula, MS 302.3 mi Moss Point, MS 301.6 mi Bay Saint Louis, MS 290.5 mi Ocean Springs, MS 284.4 mi Waynesboro, MS 238.9 mi Corinth, MS 228.8 mi
Escape planner: Picayune, MS Scenic drives in MS

Explore more options from Picayune, MS or browse trips ending in City of Greenville, MS.

Looking for more statewide routes? Browse MS road trips.