Embarking from Picayune, Mississippi, your journey to the City of Greenville, Mississippi, covers 268.9 miles and is estimated to take about 4 hours and 32 minutes of driving time. This drive is easily manageable as a single-day trip, with a projected fuel cost of around $41. You'll primarily navigate via Highway 43 North and US 49 North, with a brief stretch on East Sycamore Road. The route offers a local driving experience, suggesting you'll encounter more turns and varied road conditions than a typical interstate cruise. Given both the origin and destination are within the Southeast region, expect a consistent regional feel throughout your travels.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
135 miles from Picayune, MS
A natural place for your longest stop of the day
, about 2h 37m into the drive
.
Main Roads
Road
Distance
Duration
US 49
89.3 mi
1h 49m
I 59
61 mi
1h 5m
US 49W
46.7 mi
56m
Medgar Evers Boulevard
39.5 mi
48m
US 82
15.8 mi
19m
MS 182
8.3 mi
12m
I 20
4.3 mi
5m
US 11
1.5 mi
2m
Longest stretch:
US 49
— 89.3 mi, about 1h 49m
Traffic on I-20
Hour-of-day weekday pattern from 14 FHWA count stations on your route.
Peak
7 AM
~2,710 veh/hr typical
· worst 4,827
Quietest
2 AM
~220 veh/hr
Peak-to-quiet ratio
12.3×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 51 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Picayune, MS and City of Greenville, MS.
1
Start on East Canal Street
0.1 mi·21 sec·East Canal Street
2
Turn right onto US 11
1.5 mi·2 min·US 11
3
Turn right onto MS 43
1.1 mi·1 min·Highway 43 North
4
Continue on East Sycamore Road
0.2 mi·19 sec·East Sycamore Road
5
Take the ramp
0.2 mi·33 sec
6
Merge onto I 59
61 mi·1 hr 5 min·I 59
Use the straight / slight right lanes.
7
Take the exit
0.2 mi·38 sec
Toward US 49 North, MS 42 West: JacksonUse the slight right lane.
8
Continue on US 49
1.2 mi·1 min·US 49
Use the straight lane.
9
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
10
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
11
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
12
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
13
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
14
Take the exit onto US 49
0.2 mi·21 sec·US 49
15
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
16
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
17
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
18
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
19
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
20
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
21
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
22
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
23
Turn left onto US 82
2.4 mi·3 min·US 82
24
Keep slight left at fork onto US 82
0.4 mi·29 sec·US 82
25
Keep slight left at fork onto US 82
13 mi·15 min·US 82
26
Turn right onto MS 182
8.3 mi·12 min·MS 182
27
Turn left onto MS 1
1.0 mi·1 min·Martin Luther King Junior Boulevard
28
Turn right onto East Reed Road
0.7 mi·1 min·East Reed Road
29
Turn left onto Sandy Avenue
46 ft·2 sec·Sandy Avenue
30
Arrive at destination
Sandy Avenue
Trip Plan
With a total drive time of just over 4.5 hours, this trip is best suited for a single day, allowing for flexibility in your departure time. Consider an early morning start to maximize your daylight hours and minimize potential traffic, especially as you navigate through local areas. With only one suggested stop, you have plenty of room to decide when and where to take breaks based on your comfort. Keep an eye on your fuel gauge, as the $41 estimated cost is based on the full 268.9 miles, and local roads can sometimes be less predictable for fuel availability. A practical tip for this 'turn-heavy' route is to ensure your navigation system is fully charged and updated before you depart.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 135 miles from Picayune, MS, or about 2h 37m into the drive.
The longest continuous stretch on this route runs about 89.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 59 miles or 1h 5m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 135 miles or 2h 37m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 24m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Picayune, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Picayune, MS
This is one driving day of about 270.1 miles and 5h 26m.
Your first comfortable stop window is around 59 miles from Picayune, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 89.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 18
5 decision points cluster between mile 3.2 and 152.5 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
3.2 mi into trip|~5m in|I 59
Merge onto I 59
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
7
64.1 mi into trip|~1h 10m in
Take the exit toward US 49 North, MS 42 West: Jackson
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward US 49 North, MS 42 West: Jackson
5
146.5 mi into trip|~2h 51m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
6
149.8 mi into trip|~2h 56m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
5
152.5 mi into trip|~2h 59m in|US 49
Take the exit onto US 49 toward I 220 North, I 49 North: North Jackson, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 220 North, I 49 North: North Jackson,...
Fuel & Cost
Regular Gas
$37.49 one way
$74.99 round trip
$3.53/gal25.4 MPG avg95 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$3.95
$41.95
$83.90
premium
$4.29
$45.61
$91.22
diesel
$4.80
$51.00
$102.00
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$37
Meals
$25–$50
Total
$62–$87
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 94.5 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $28 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
81
1
$28.36
$12.96
Efficient EV
67.5
0
$23.63
$10.80
EV Truck/SUV
108
1
$37.81
$17.29
Gas CO2
95 kg
EV CO2
32 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 18, 2026
Origin
Picayune, MS
Late night
in Picayune on Sunday
Local time
2:07 AM
CDT
Current temp
75°F
Mostly Clear
0 mph1% chanceLive forecast
Heat Advisory
Heat Advisory issued July 17 at 11:57PM CDT until July 20 at 7:00PM CDT by NWS Jackson MS
Heat Advisory
Heat Advisory issued July 17 at 10:48PM CDT until July 18 at 8:00PM CDT by NWS Memphis TN
Destination
City of Greenville, MS
Late night
in City of Greenville on Sunday
Local time
2:07 AM
CDT
Current temp
75°F
Partly Cloudy
0 mph2% chanceLive forecast
Heat Advisory
Heat Advisory issued July 17 at 11:57PM CDT until July 20 at 7:00PM CDT by NWS Jackson MS
Heat Advisory
Heat Advisory issued July 17 at 10:48PM CDT until July 18 at 8:00PM CDT by NWS Memphis TN
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
5h 26m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
2 mi from route
~5 min detour
Free
near mile 158.3
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is characterized as a 'turn-heavy local drive,' meaning you won't be on a limited-access highway for the majority of your trip, as indicated by the 0% highway share. Expect a more engaging driving experience with frequent changes in direction and potentially slower speeds as you pass through various communities. While there isn't a specified longest uninterrupted stretch, the nature of this route suggests you'll be making regular adjustments to your course. The progression will likely involve a mix of state highways and local roads, requiring your attention to navigation.
84% highway — fuel and pacing are the main things to plan.
30 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 89.3 mi on US 49.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on US 49 and I 59. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 3.2 miles in near I 59.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 270.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 3.2 miles (I 59): Merge point - match speed before joining. Lane positioning matters here; at 64.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 146.5 miles (US 49): Highway fork - watch signs carefully.
Elevation Profile
Mostly flat terrain
354 ft60 ft
Total Climb
354 ft
Total Descent
288 ft
Highest Point
354 ft
~77.2 mi in
Elevation Range
294 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Picayune, MS and City of Greenville, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Jackson
146.5 mi in|~2h 51m|via US 49
Yazoo City
149.8 mi in|~2h 56m|via I 20; US 49
Vicksburg
197.5 mi in|~3h 54m|via US 49W
Detours Along the Way
Tagged by where each one fits in your drive — first break, midpoint, final stretch.
PJ's Coffee
Cafe
Near the start, right off the route
0.2 mi from route
~1 min detour
Creekside Coffee Cafe
Cafe
Near the start, short detour
1.5 mi from route
~4 min detour
Picayune, MS
Hours: Mo-Fr 06:00-20:00; Sa 07:00-20:00; Su 08...
Doable as a same-day drive at 5h 26m. Total distance: 270.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 26m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (84%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 89.3 miles on US 49. The full list of main roads is in the Roads section above.
Yes — we found about 13 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at City of Greenville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 13 rest areas along the route for bathroom stops.
The main spots that need attention: at 3.2 miles (I 59): Merge point - match speed before joining. Lane positioning matters here; at 64.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 146.5 miles (US 49): Highway fork - watch signs carefully.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.4 hours each way, a round trip means 10.9 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at City of Greenville, MS before the return drive.
