O'Fallon, MO to Hannibal, MO is 84.7 miles and takes about 1h 44m via Avenue of the Saints and I-70, with a fuel budget near $13 and enough daylight to finish in a day. This trip stays within Missouri, moving between the Midwest region's familiar landscapes. It's a relatively short drive, making it ideal for a single day's excursion. You'll find this route offers a straightforward path, primarily utilizing surface roads once you leave the interstate.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
42.4 miles from O'Fallon, MO
A natural place for your longest stop of the day
, about 51m into the drive
.
Main Roads
Road
Distance
Duration
Avenue of the Saints
72.7 mi
1h 25m
I 70
6.9 mi
8m
Warren Barett Drive
3 mi
5m
South Main Street
0.6 mi
1m
Broadway
0.6 mi
1m
Grand Avenue
0.2 mi
<1m
West Terra Lane
0.1 mi
<1m
Longest stretch:
Avenue of the Saints
— 72.7 mi, about 1h 25m
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon, MO and Hannibal, MO.
1
Start on this road
25 ft·7 sec·this road
2
Turn left onto South Main Street
0.6 mi·1 min·South Main Street
3
Turn left
34 ft·6 sec
Toward I 70 EastUse the left lane.
4
Turn sharp left onto South Main Street
284 ft·11 sec·South Main Street
5
Turn left onto West Terra Lane
0.1 mi·12 sec·West Terra Lane
Use the left lane.
6
Take the ramp
479 ft·6 sec
Toward I 70 West
7
Merge onto I 70
6.9 mi·8 min·I 70
Use the straight / slight right lanes.
8
Take the exit
0.4 mi·47 sec
Exit 210BToward US 61 North: HannibalUse the slight right lane.
9
Merge onto US 61
73 mi·1 hr 25 min·Avenue of the Saints
Use the right lane.
10
Turn right onto Warren Barett Drive
3.0 mi·5 min·Warren Barett Drive
11
Turn left onto Grand Avenue
0.2 mi·23 sec·Grand Avenue
12
Turn right onto Broadway
0.6 mi·1 min·Broadway
13
Turn right
54 ft·3 sec
14
Arrive at destination
Trip Plan
Given the short 1h 44m duration and 84.7-mile distance, this trip offers significant flexibility. Consider departing mid-morning to avoid rush hour and allow for a leisurely pace. The fuel cost is estimated at $13, so plan accordingly. While there are no designated stops in the data, keep an eye out for potential local eateries or points of interest along Avenue of the Saints, as this section comprises the bulk of your drive. You'll be on surface roads for most of the trip, so be mindful of local speed limits.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 42.4 miles from O'Fallon, MO, or about 51m into the drive.
The longest continuous stretch on this route runs about 72.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 19 miles or 24m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 42.4 miles or 51m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 26m
Traffic, exits, and arrival timing usually matter more near Hannibal, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving O'Fallon, MO so your first major turns are already loaded.
Day 1
Settle into the route from O'Fallon, MO
This is one driving day of about 84.7 miles and 1h 44m.
Your first comfortable stop window is around 19 miles from O'Fallon, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on Avenue of the Saints for about 72.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 12
5 decision points cluster between mile 0.6 and 7.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
0.6 mi into trip|~1m in
Turn left toward I 70 East
Lane positioning matters here
Use the left lane.
Toward I 70 East
6
0.6 mi into trip|~1m in|South Main Street
Turn sharp left onto South Main Street
Sharp turn - reduce speed on approach
6
0.7 mi into trip|~2m in|West Terra Lane
Turn left onto West Terra Lane
Lane positioning matters here
Use the left lane.
5
0.9 mi into trip|~2m in|I 70
Merge onto I 70
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
7
7.8 mi into trip|~10m in
Take the exit toward US 61 North: Hannibal
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 210B
Toward US 61 North: Hannibal
Fuel & Cost
Regular Gas
$13.24 one way
$26.48 round trip
$3.97/gal25.4 MPG avg30 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$14.54
$29.08
premium
$4.89
$16.30
$32.60
diesel
$5.61
$18.70
$37.40
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$13
Meals
$25–$50
Total
$38–$63
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 29.6 kg one way.
Prices: EIA weekly data, 2026-04-13.
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $9 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
25.4
0
$8.89
$4.07
Efficient EV
21.2
0
$7.41
$3.39
EV Truck/SUV
33.9
0
$11.86
$5.42
Gas CO2
30 kg
EV CO2
10 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 19, 2026
Origin
O'Fallon, MO
Late night
in O'Fallon on Sunday
Local time
12:58 AM
CDT
Current temp
39°F
Clear
W 3 to 10 mph0% chanceLive forecast
Flood Warning
Flood Warning issued April 18 at 8:47PM CDT by NWS St Louis MO
Flood Warning
Flood Warning issued April 18 at 8:47PM CDT by NWS St Louis MO
Destination
Hannibal, MO
Late night
in Hannibal on Sunday
Local time
12:58 AM
CDT
Current temp
74°F
Unavailable
Live forecast
76°F
Troy, MO
42 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
35 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
1h 44m on the road
The weather snapshot is not static. If you are leaving later, give both cities one more quick forecast check before departure.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This route is mostly surface roads, with only an 8% highway share. You'll spend the majority of your time on local roads, with the longest continuous stretch being 72.7 miles on Avenue of the Saints. Expect to encounter more frequent intersections and slower speeds as you transition from the interstate environment.
Only 8% highway — the rest is turn-by-turn surface driving.
14 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 72.7 mi on Avenue of the Saints.
How Hard Is This Drive?
5/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 12 points where you need to pay attention to lane position or signs. The trickiest moment comes around 0.6 miles in.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 84.7 miles you will encounter 12 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 0.6 miles: Lane positioning matters here; at 0.6 miles (South Main Street): Sharp turn - reduce speed on approach; at 0.7 miles (West Terra Lane): Lane positioning matters here.
Hannibal is a city in Missouri. It is located approximately 100 miles northwest of St. Louis and is located on the west bank of the Mississippi River.
Hannibal is best known as the boyhood home of author Samuel Longhorn Clemens, more commonly known as Mark Twain. Twain's The Adventures of Tom Sawyer and Adventures of Huckleberry Finn are set in Hannibal. Many historical sites in the city revolve around Twain and his writings, which occupy a prominent place in the history of the Underground Railroad era.
Doable as a same-day drive at 1h 44m. Total distance: 84.7 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
1h 44m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (8%). Some complex stretches to watch for.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 72.7 miles on Avenue of the Saints. The full list of main roads is in the Roads section above.
Yes. At under 2 hours behind the wheel, this works well for families — plan one quick stop if you have younger kids.
The main spots that need attention: at 0.6 miles: Lane positioning matters here; at 0.6 miles (South Main Street): Sharp turn - reduce speed on approach; at 0.7 miles (West Terra Lane): Lane positioning matters here.
Yes. A round trip is manageable in a single day if you plan a break at Hannibal, MO before heading back.
