Connecting Hannibal to St. Louis is a straightforward 117-mile journey that typically takes about 1 hour and 53 minutes. Because of the relatively short distance, this trip is perfectly manageable as a simple one-day excursion, meaning you won't need to worry about booking an overnight stay. You can expect to spend approximately $17 on fuel for the trip, making it a budget-friendly way to move between these two Missouri cities. Since both locations are situated within the Midwest, the drive keeps you firmly rooted in the region's landscape. If you prefer a relaxed pace without the pressure of an interstate trek, this local route offers a direct, no-fuss path to your destination.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
58.4 miles from Hannibal, MO
A natural place for your longest stop of the day
, about 1h 12m into the drive
.
Main Roads
Road
Distance
Duration
Avenue of the Saints
100.7 mi
2h
Jack Buck Memorial Highway
5.8 mi
7m
Daniel Boone Expressway
5.7 mi
7m
Warren Barett Drive
3 mi
5m
Broadway
0.6 mi
1m
South 14th Street
0.3 mi
<1m
Grand Avenue
0.2 mi
<1m
Market Street
0.2 mi
<1m
Longest stretch:
Avenue of the Saints
— 100.7 mi, about 2h
Turn-by-Turn Driving Directions
Step-by-step road directions between Hannibal, MO and St. Louis, MO.
1
Start on this road
54 ft·9 sec·this road
2
Turn left onto Broadway
0.6 mi·1 min·Broadway
3
Turn left onto US 61 Business
0.2 mi·23 sec·Grand Avenue
4
Turn right onto Warren Barett Drive
3.0 mi·5 min·Warren Barett Drive
5
Turn left onto US 61
101 mi·2 hr·Avenue of the Saints
Use the right lane.
6
Continue on I 64; US 40
5.7 mi·7 min·Daniel Boone Expressway
Use the straight lane.
7
Continue on I 64; US 40
5.8 mi·7 min·Jack Buck Memorial Highway
Use the straight / slight right lanes.
8
Take the exit
0.2 mi·34 sec
Exit 39AToward 14th StreetUse the slight right lane.
9
Turn left onto South 14th Street
0.3 mi·42 sec·South 14th Street
Use the left lane.
10
Turn right onto Market Street
0.2 mi·25 sec·Market Street
11
Arrive at destination
Market Street
Trip Plan
Since this is a sub-two-hour drive, you have plenty of flexibility to plan your departure time around your personal schedule rather than rushing to beat traffic. With no mandatory stops required to cover the 117 miles, you can complete the trip in one sitting, though building in a quick break can help you stay refreshed for the more technical, turn-heavy sections. Keep an eye on your fuel gauge before you head out, as the $17 estimated cost can fluctuate based on your vehicle's efficiency on local roads. My best advice is to familiarize yourself with the specific turns on Grand Avenue and Warren Barett Drive before you pull out of Hannibal. By staying mindful of your navigation, you can enjoy a smooth, efficient trip into St. Louis.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 58.4 miles from Hannibal, MO, or about 1h 12m into the drive.
The longest continuous stretch on this route runs about 100.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 26 miles or 33m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 58.4 miles or 1h 12m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 56m
Traffic, exits, and arrival timing usually matter more near St. Louis, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Hannibal, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Hannibal, MO
This is one driving day of about 116.7 miles and 2h 23m.
Your first comfortable stop window is around 26 miles from Hannibal, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on Avenue of the Saints for about 100.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 7
5 decision points cluster between mile 0 and 116.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
0 mi into trip|~0m in|Broadway
Turn left onto Broadway
Navigation decision point
4
0.8 mi into trip|~1m in|Warren Barett Drive
Turn right onto Warren Barett Drive
Navigation decision point
6
3.8 mi into trip|~7m in|US 61 / Avenue of the Saints
Turn left onto US 61 / Avenue of the Saints
Lane positioning matters here
Use the right lane.
7
116 mi into trip|~2h 21m in
Take the exit toward 14th Street
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 39A
Toward 14th Street
5
116.2 mi into trip|~2h 22m in|South 14th Street
Turn left onto South 14th Street
Lane positioning matters here
Use the left lane.
Fuel & Cost
Regular Gas
$18.24 one way
$36.49 round trip
$3.97/gal25.4 MPG avg41 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$20.03
$40.06
premium
$4.89
$22.46
$44.92
diesel
$5.61
$25.77
$51.53
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$18
Meals
$25–$50
Total
$43–$68
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 40.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $12 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
35
0
$12.25
$5.60
Efficient EV
29.2
0
$10.21
$4.67
EV Truck/SUV
46.7
0
$16.34
$7.47
Gas CO2
41 kg
EV CO2
14 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Hannibal, MO
Late night
in Hannibal on Tuesday
Local time
3:08 AM
CDT
Current temp
67°F
Unavailable
Live forecast
Destination
St. Louis, MO
Late night
in St. Louis on Tuesday
Local time
3:08 AM
CDT
Current temp
70°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 23m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a turn-heavy local drive rather than a monotonous highway cruise, as this route features zero highway miles. You will navigate via Broadway, Grand Avenue, and Warren Barett Drive, which keeps you off the major interstates entirely. Because there is no single long-distance stretch on Broadway, you will be making frequent adjustments behind the wheel throughout the entire 117-mile duration. This creates a more engaged driving experience that demands your attention on local roads. The lack of highway share ensures you see the landscape from a different perspective than you would on a standard freeway, though it does mean the pace is dictated by local traffic patterns.
Only 5% highway — the rest is turn-by-turn surface driving.
11 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 100.7 mi on Avenue of the Saints.
How Hard Is This Drive?
2/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. Navigation is very simple - set it and forget it for most of the drive. The trickiest moment comes early in the drive near Broadway.
Driving Effort2/10
Very easy - short and simple to drive
Balances navigation complexity with total wheel time.
The drive from Hannibal, MO to St. Louis, MO is easy. At 2h 23m with 5% highway, most drivers will find it relaxed and low-stress.
Where does it get tricky?
The main spots that need attention: near the start (Broadway): Navigation decision point; at 0.8 miles (Warren Barett Drive): Navigation decision point; at 3.8 miles (US 61 / Avenue of the Saints): Lane positioning matters here.
Hannibal is a city in Missouri. It is located approximately 100 miles northwest of St. Louis and is located on the west bank of the Mississippi River.
Hannibal is best known as the boyhood home of author Samuel Longhorn Clemens, more commonly known as Mark Twain. Twain's The Adventures of Tom Sawyer and Adventures of Huckleberry Finn are set in Hannibal. Many historical sites in the city revolve around Twain and his writings, which occupy a prominent place in the history of the Underground Railroad era.
The Gateway City of St. Louis is the epitome of the modern Midwestern metropolis. Missouri's second-largest city is vibrant but laid-back, populous but navigable, historic but still relevant. The city's planners have created an aesthetically beautiful city, with plenty of green space amidst buildings both old and new, framed by the majestic Mississippi and Missouri rivers. And capping it all is the world's tallest man-made monument, the beautiful and iconic Gateway Arch.
St. Louis is a city of culture and surprisingly inexpensive. Among American cities, only Washington, D.C. has more free attractions for tourists and residents alike. Hotels, restaurants, and even parking garages avoid the premium pricing common in other big cities. Although often overlooked, St. Louis can be an affordable, educational, and fun family getaway.
The longest stretch is about 100.7 miles on Avenue of the Saints. The full list of main roads is in the Roads section above.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: near the start (Broadway): Navigation decision point; at 0.8 miles (Warren Barett Drive): Navigation decision point; at 3.8 miles (US 61 / Avenue of the Saints): Lane positioning matters here.
Yes. A round trip is manageable in a single day if you plan a break at St. Louis, MO before heading back.
