Trip from Greenfield, MO to St. Louis, MO

Compiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Apr 19, 2026 · Editorial standards

Drive Time

4h 52m

Distance

253.2 mi

407 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$40

one way

EV Charging

Good

8 stations

Best Time to Leave

Save up to 41 min

4 AM

4h 39m ★

6 AM

4h 53m

8 AM

5h 20m

10 AM

5h 2m

12 PM

5h 0m

3 PM

5h 4m

5 PM

5h 18m

8 PM

4h 45m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly

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Greenfield, MO

Orhan Pergel

Trip Overview

This 253.5-mile journey from Greenfield, MO, to St. Louis, MO, is designed for a single day of travel, taking approximately 4 hours and 3 minutes to complete. You'll navigate primarily local roads, indicated by a 0% highway share, making it a turn-heavy experience. Budget around $39 for fuel for this trip. Given its manageable length and local road focus, this route is ideal for a straightforward day trip, allowing for flexibility in your departure and arrival times. Both your origin and destination are within the Midwest region, so you'll be traversing familiar territory.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

126.6 miles from Greenfield, MO

A natural place for your longest stop of the day , about 2h 30m into the drive .

Main Roads

Road	Distance	Duration
Payne Stewart Highway	201.3 mi	3h 39m
N Grand Street	31 mi	42m
US 160	5.5 mi	7m
Police Officer Ernest M. Brockman Sr. Memorial Highway	3.5 mi	4m
Officer Michael Barwick Memorial Highway	3.5 mi	4m
Police Officer Robert Stanze Memorial Highway	2.7 mi	3m
Officer David Haynes Memorial Highway	2.3 mi	3m
South Jefferson Avenue	1.3 mi	2m

Longest stretch: Payne Stewart Highway — 201.3 mi, about 3h 39m

Turn-by-Turn Driving Directions

Step-by-step road directions between Greenfield, MO and St. Louis, MO.

Start on South Allison Avenue

0.3 mi · 1 min · South Allison Avenue

At end of road, turn left onto Talbutt Street

183 ft · 10 sec · Talbutt Street

Turn right onto Lilly Street

0.2 mi · 49 sec · Lilly Street

Turn right onto US 160

31 mi · 42 min · N Grand Street

Enter roundabout onto US 160

95 ft · 3 sec · US 160

Continue on US 160

0.6 mi · 47 sec · US 160

Enter roundabout onto US 160

128 ft · 4 sec · US 160

Continue on US 160

1.3 mi · 1 min · US 160

Enter roundabout onto US 160

110 ft · 4 sec · US 160

Continue on US 160

3.6 mi · 4 min · US 160

Take the ramp

0.3 mi · 39 sec

Merge onto I 44

201 mi · 3 hr 39 min · Payne Stewart Highway

Use the straight / slight right lanes.

Continue on I 44; US 50

3.5 mi · 4 min · Police Officer Ernest M. Brockman Sr. Memorial Highway

Use the straight / slight right lanes.

Continue on I 44

2.7 mi · 3 min · Police Officer Robert Stanze Memorial Highway

Continue on I 44

3.5 mi · 4 min · Officer Michael Barwick Memorial Highway

Continue on I 44

2.3 mi · 3 min · Officer David Haynes Memorial Highway

Take the exit

0.2 mi · 21 sec

Exit 289 Toward Jefferson Avenue Use the slight right lane.

Turn left onto South Jefferson Avenue

1.3 mi · 2 min · South Jefferson Avenue

Turn right onto Market Street

1.0 mi · 1 min · Market Street

Arrive at destination

Market Street

Trip Plan

Given the 4-hour duration and the turn-heavy nature of this 253.5-mile drive, leaving Greenfield, MO, in the morning is advisable to give you ample time in St. Louis. With only one recommended stop, plan for a brief break to refuel or stretch your legs. The estimated fuel cost is $39, so ensure your tank is full before you depart. Pay close attention to local signage as you transition between Talbutt Street, Lilly Street, and N Grand Street, as these will be your primary navigational points. This route's flexibility means you can adjust your timing based on traffic or personal preference.

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 126.6 miles from Greenfield, MO, or about 2h 30m into the drive.

The longest continuous stretch on this route runs about 201.3 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 56 miles or 1h 12m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 126.6 miles or 2h 30m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 3h 58m

Traffic, exits, and arrival timing usually matter more near St. Louis, MO than in the middle of the route.

Before You Leave

Open the route before leaving Greenfield, MO so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Greenfield, MO

This is one driving day of about 253.2 miles and 4h 52m.

Your first comfortable stop window is around 56 miles from Greenfield, MO.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

The longest stretch is on Payne Stewart Highway for about 201.3 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

city in and the county seat of Pulaski County, Missouri, United States

Mid-route town

Meal stop

Waynesville, MO

127 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Popular next leg

Waynesville, MO to St. Louis, MO

133.7 mi · 2h 33m

Pacing Suggestions

Marshfield, MO

Fuel and coffee

A short stop after about 56 miles helps settle the day before fatigue starts building.

Waynesville, MO

Meal break

The midpoint is around 126.6 miles from Greenfield, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before Payne Stewart Highway if your tank is already low. That segment runs about 201.3 miles.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Nearby Places

Restaurants, cafes, gas stations and more along your route.

Top Restaurant

Mayo Ketchup

4.6 ★ ★ ★ ★ ★

St. Louis, Missouri

Near the end, short detour

1.6 mi from route ~4 min detour mile 253.2

Hours: 11 am–8 pm

+13146962699

Visit website

Frazer's Restaurant & Lounge

4.7 ★ ★ ★ ★ ★

St. Louis, Missouri

2.2 mi

Mayo Ketchup

4.6 ★ ★ ★ ★ ★

Near the end, short detour

1.6 mi from route ~4 min detour mile 253.2

St. Louis, Missouri

Hours: 11 am–8 pm

+13146962699

Visit website

Frazer's Restaurant & Lounge

4.7 ★ ★ ★ ★ ★

Near the end, short detour

2.2 mi from route ~5 min detour Expensive mile 253.2

St. Louis, Missouri

Hours: 5–10 pm

+13147738646

Visit website

Havana's Cuisine Restaurant

4.8 ★ ★ ★ ★ ★

Near the end, ~9 min detour

3.6 mi from route ~9 min detour $10 to $20 mile 253.2

St. Louis, Missouri

Hours: 11 am–9 pm

+13143125005

Visit website

Sawmill BBQ Restaurant

4.7 ★ ★ ★ ★ ★

Near the end, ~9 min detour

3.8 mi from route ~9 min detour $10 to $20 mile 253.2

Sauget, Illinois

Hours: 10 am–8 pm

+16183323000

Visit website

TK's Pizza

4.4 ★ ★ ★ ★ ☆

Around the midpoint, ~11 min detour

4.3 mi from route ~11 min detour $10 to $20 mile 126.6

St Robert, Missouri

Hours: 11 am–9 pm

+15733363278

Visit website

Slim Chickens

3.6 ★ ★ ★ ★ ☆

Near the end, ~12 min detour

4.9 mi from route ~12 min detour $10 to $20 mile 253.2

St. Louis, Missouri

Hours: 7 am–3 pm

+13149327723

Visit website

Tesla Supercharger

4.3 ★ ★ ★ ★ ☆

Around the midpoint, right off the route

1 mi from route ~2 min detour mile 144.7

Rolla, Missouri

Hours: Open 24 hours

Visit website

Electrify America Charging Station

3.6 ★ ★ ★ ★ ☆

Around the midpoint, right off the route

0.8 mi from route ~2 min detour mile 90.4

Lebanon, Missouri

Hours: Open 24 hours

+18336322778

Visit website

4.6 ★ ★ ★ ★ ★

Near the end, right off the route

0.6 mi from route ~2 min detour mile 253.2

St. Louis, Missouri

Hours: 10 am–10 pm

+13149233960

Visit website

Place data sourced from public business listings. Hours and availability may vary.

Heads-up: tricky spots

5 of 10

5 decision points cluster between mile 0.3 and 250.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.

0.3 mi into trip | ~1m in | Talbutt Street

At end of road, turn left onto Talbutt Street

Navigation decision point

0.3 mi into trip | ~1m in | Lilly Street

Turn right onto Lilly Street

Navigation decision point

31.5 mi into trip | ~44m in | US 160

Enter roundabout onto US 160

Roundabout - know your exit number before entering

37.3 mi into trip | ~52m in | I 44 / Payne Stewart Highway

Merge onto I 44 / Payne Stewart Highway

Merge point - match speed before joining. Lane positioning matters here

Use the straight / slight right lanes.

250.7 mi into trip | ~4h 47m in

Take the exit toward Jefferson Avenue

Exit ramp - move to the correct lane early. Lane positioning matters here

Use the slight right lane. Exit 289 Toward Jefferson Avenue

Fuel & Cost

Regular Gas

$39.58 one way

$79.17 round trip

$3.97/gal 25.4 MPG avg 89 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.36	$43.46	$86.93
premium	$4.89	$48.73	$97.45
diesel	$5.61	$55.90	$111.81

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$40

Meals

$25–$50

Total

$65–$90

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 88.6 kg one way. Prices: EIA weekly data, 2026-04-13.

Driving Electric?

About $27 in charging · 0 stops · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	76	0	$26.59	$12.15
Efficient EV	63.3	0	$22.15	$10.13
EV Truck/SUV	101.3	1	$35.45	$16.20

Gas CO2

89 kg

EV CO2

30 kg (66% less)

Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast as of Apr 17, 2026

Origin

Greenfield, MO

Late night in Greenfield on Sunday

Local time

2:47 AM

CDT

Current temp

54°F

Unavailable

Live forecast

Destination

St. Louis, MO

Late night in St. Louis on Sunday

Local time

2:47 AM

CDT

Current temp

61°F

Mostly Clear

S 5 mph 2% chance Live forecast

Flood Warning

Flood Warning issued April 16 at 10:12PM CDT by NWS St Louis MO

Flood Warning

Flood Warning issued April 16 at 10:12PM CDT by NWS St Louis MO

76°F

Waynesville, MO

127 mi in

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

7 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

4h 52m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

National Parks Near This Route

Worth a detour if your schedule allows.

Gateway Arch National Park

National Park

Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...

0 mi from route ~1 min detour $19 near mile 253.5

View on nps.gov

Wilson's Creek National Battlefield

National Battlefield

Wilson's Creek was the first major Civil War battle fought west of the Mississippi River, and where the first Union general was killed in action. The costly Southern victory on August 10, 1861, focuse...

12 mi from route ~29 min detour Free near mile 35

View on nps.gov

Park data from the National Park Service API. Alerts update every 2 hours.

What kind of drive is this?

Expect a turn-heavy local drive for the entirety of this 253.5-mile route, with no highway segments. Your journey will begin on Talbutt Street, Lilly Street, and N Grand Street, setting the tone for a road that demands attention to turns and local navigation. Since there are no significant highway stretches, the longest uninterrupted drive time will likely be limited, requiring you to stay engaged with frequent changes in direction. This type of driving profile means you'll be experiencing the local landscape more intimately, rather than at highway speeds.

Only 2% highway — the rest is turn-by-turn surface driving.

20 navigation steps total — most of the decisions cluster near the start and finish.

Longest single stretch: 201.3 mi on Payne Stewart Highway.

How Hard Is This Drive?

3/10

Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way. The trickiest moment comes around 0.3 miles in near Talbutt Street.

Driving Effort 3/10

Easy - simple navigation with a manageable amount of wheel time

Balances navigation complexity with total wheel time.

This is a straightforward 4h 52m drive. You will face about 10 decision points, but nothing that requires special attention if you follow navigation.

Where does it get tricky?

The main spots that need attention: at 0.3 miles (Talbutt Street): Navigation decision point; at 0.3 miles (Lilly Street): Navigation decision point; at 31.5 miles (US 160): Roundabout - know your exit number before entering.

About the Cities

Arriving in St. Louis, MO

Full guide →

The Gateway City of St. Louis is the epitome of the modern Midwestern metropolis. Missouri's second-largest city is vibrant but laid-back, populous but navigable, historic but still relevant. The city's planners have created an aesthetically beautiful city, with plenty of green space amidst buildings both old and new, framed by the majestic Mississippi and Missouri rivers. And capping it all is the world's tallest man-made monument, the beautiful and iconic Gateway Arch. St. Louis is a city of culture and surprisingly inexpensive. Among American cities, only Washington, D.C. has more free attractions for tourists and residents alike. Hotels, restaurants, and even parking garages avoid the premium pricing common in other big cities. Although often overlooked, St. Louis can be an affordable, educational, and fun family getaway.

City content from Wikivoyage (CC BY-SA 4.0) and Wikidata (CC0).

Who Is This Route For?

Weekend Trip

Doable as a same-day drive at 4h 52m. Total distance: 253.2 miles.

Family Friendly

Moderate complexity with 1 natural rest stops along the way.

Solo Traveler

4h 52m drive, comfortable solo distance.

First-Time Driver

Mostly highway driving (2%). Straightforward navigation.

Scenic Drive

Mostly surface roads route profile with national parks nearby.

Frequently Asked Questions

The longest stretch is about 201.3 miles on Payne Stewart Highway. The full list of main roads is in the Roads section above.

We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.

Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.

Yes — Gateway Arch National Park and Wilson's Creek National Battlefield. See the National Parks section for detour distances and tips on detours.

Possible but tiring. At 4.9 hours each way, an in-and-out day trip would put you behind the wheel for 9.8 hours — manageable with a long break at St. Louis, MO, but most travelers stay overnight.

How this page is built

Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.

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Trip from Greenfield, MO to St. Louis, MO

Best Time to Leave

Trip Overview

Main Roads

Turn-by-Turn Driving Directions

Trip Plan

Before You Leave

Where to Stop

Pacing Suggestions

Nearby Places

Mayo Ketchup

Mayo Ketchup

Frazer's Restaurant & Lounge

Havana's Cuisine Restaurant

Sawmill BBQ Restaurant

TK's Pizza

Slim Chickens

Tesla Supercharger

Electrify America Charging Station

Tesla Destination Charger

Tesla Destination Charger

Flying J EV Charging Station

Tesla Supercharger

Tesla Destination Charger

Dynamic EVC Charging Station Charging Station

St. Louis Union Station

Heads-up: tricky spots

Fuel & Cost

Travel Intel

Greenfield, MO

St. Louis, MO

Same local time

7 degrees warmer at arrival

4h 52m on the road

National Parks Near This Route

Gateway Arch National Park

Wilson's Creek National Battlefield

What kind of drive is this?

How Hard Is This Drive?

About the Cities

Arriving in St. Louis, MO

Who Is This Route For?

Frequently Asked Questions

Which road carries most of the drive?

Are there rest areas on this route?

Is this a good trip with kids?

Where does this route get tricky?

Are there national parks near this route?

Can I do this as a round trip in one go?

How this page is built

Explore More

Continue From St. Louis, MO

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