Hannibal, MO to O'Fallon, MO is 84.9 miles and takes about 1h 44m via Avenue of the Saints, with a fuel budget near $13 and enough daylight to finish in a day. This trip stays within Missouri, traversing the Midwest region. Expect a local drive with frequent turns rather than a high-speed interstate journey. With a total duration under two hours and a modest fuel cost, this route is ideal for a spontaneous day trip or an easy connection between these two points.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
42.4 miles from Hannibal, MO
A natural place for your longest stop of the day
, about 52m into the drive
.
Main Roads
Road
Distance
Duration
Avenue of the Saints
73.2 mi
1h 26m
Dwight D Eisenhower Highway
6.4 mi
7m
Warren Barett Drive
3 mi
5m
Broadway
0.6 mi
1m
South Main Street
0.6 mi
1m
Grand Avenue
0.2 mi
<1m
Drennen Parkway
<0.1 mi
<1m
Longest stretch:
Avenue of the Saints
— 73.2 mi, about 1h 26m
Turn-by-Turn Driving Directions
Step-by-step road directions between Hannibal, MO and O'Fallon, MO.
1
Start on this road
54 ft·9 sec·this road
2
Turn left onto Broadway
0.6 mi·1 min·Broadway
3
Turn left onto US 61 Business
0.2 mi·23 sec·Grand Avenue
4
Turn right onto Warren Barett Drive
3.0 mi·5 min·Warren Barett Drive
5
Turn left onto US 61
73 mi·1 hr 26 min·Avenue of the Saints
Use the right lane.
6
Take the exit
0.5 mi·51 sec
Toward I 70 East: Saint LouisUse the slight left / straight lanes.
7
Merge onto I 70
6.4 mi·7 min·Dwight D Eisenhower Highway
Use the straight / slight right lanes.
8
Take the exit
0.3 mi·43 sec
Toward MO K: O'FallonUse the straight / slight right lanes.
9
Turn straight onto Drennen Parkway
150 ft·3 sec·Drennen Parkway
Toward MO K: O'Fallon
10
Keep slight right at fork onto Drennen Parkway
166 ft·5 sec·Drennen Parkway
Toward MO K: O'Fallon
11
Turn slight left
62 ft·2 sec
Toward MO K: O'Fallon
12
Continue on South Main Street
0.6 mi·1 min·South Main Street
13
Turn right
25 ft·1 sec
14
Arrive at destination
Trip Plan
Given the relatively short 1h 44m drive, you have a lot of flexibility for when you depart. Leaving in the morning allows ample time to reach O'Fallon and still have the afternoon free. With no major interstate segments, plan for your navigation system to be accurate, as many turns will guide you. The longest stretch is 73.2 miles, so make sure you have sufficient fuel before embarking, as stops are not factored into this route. The $13 fuel cost is a good estimate for this 84.9-mile journey.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 42.4 miles from Hannibal, MO, or about 52m into the drive.
The longest continuous stretch on this route runs about 73.2 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 19 miles or 25m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 42.4 miles or 52m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 27m
Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Hannibal, MO so your first major turns are already loaded.
Day 1
Settle into the route from Hannibal, MO
This is one driving day of about 84.9 miles and 1h 44m.
Your first comfortable stop window is around 19 miles from Hannibal, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on Avenue of the Saints for about 73.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 10
5 decision points cluster between mile 3.8 and 84.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
3.8 mi into trip|~7m in|US 61 / Avenue of the Saints
Turn left onto US 61 / Avenue of the Saints
Lane positioning matters here
Use the right lane.
6
77 mi into trip|~1h 33m in
Take the exit toward I 70 East: Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight left / straight lanes.
Toward I 70 East: Saint Louis
5
77.5 mi into trip|~1h 34m in|I 70 / Dwight D Eisenhower Highway
Merge onto I 70 / Dwight D Eisenhower Highway
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
6
83.9 mi into trip|~1h 42m in
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Toward MO K: O'Fallon
6
84.2 mi into trip|~1h 42m in|Drennen Parkway
Keep slight right at fork onto Drennen Parkway toward MO K: O'Fallon
Highway fork - watch signs carefully
Toward MO K: O'Fallon
Fuel & Cost
Regular Gas
$13.27 one way
$26.55 round trip
$3.97/gal25.4 MPG avg30 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$14.57
$29.15
premium
$4.89
$16.34
$32.68
diesel
$5.61
$18.74
$37.49
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$13
Meals
$25–$50
Total
$38–$63
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 29.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $9 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
25.5
0
$8.91
$4.08
Efficient EV
21.2
0
$7.43
$3.40
EV Truck/SUV
34
0
$11.89
$5.43
Gas CO2
30 kg
EV CO2
10 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Hannibal, MO
Late night
in Hannibal on Sunday
Local time
2:43 AM
CDT
Current temp
74°F
Unavailable
Live forecast
Destination
O'Fallon, MO
Late night
in O'Fallon on Sunday
Local time
2:43 AM
CDT
Current temp
57°F
Unavailable
Live forecast
76°F
Troy, MO
42 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
17 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
1h 44m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This drive is characterized by frequent turns, making it a more engaging local experience than a highway cruise. While there's no interstate driving (0% highway share), you'll find a substantial stretch of 73.2 miles on the Avenue of the Saints, offering a longer, uninterrupted segment. The route transitions through various local roads as you navigate from Hannibal towards O'Fallon, so pay close attention to your navigation, especially as you approach your destination. This isn't a high-speed affair; it's more about the journey through local landscapes.
Only 0% highway — the rest is turn-by-turn surface driving.
14 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 73.2 mi on Avenue of the Saints.
How Hard Is This Drive?
5/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 10 points where you need to pay attention to lane position or signs. The trickiest moment comes around 3.8 miles in near US 61 / Avenue of the Saints.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 84.9 miles you will encounter 10 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 3.8 miles (US 61 / Avenue of the Saints): Lane positioning matters here; at 77 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 77.5 miles (I 70 / Dwight D Eisenhower Highway): Merge point - match speed before joining. Lane positioning matters here.
Hannibal is a city in Missouri. It is located approximately 100 miles northwest of St. Louis and is located on the west bank of the Mississippi River.
Hannibal is best known as the boyhood home of author Samuel Longhorn Clemens, more commonly known as Mark Twain. Twain's The Adventures of Tom Sawyer and Adventures of Huckleberry Finn are set in Hannibal. Many historical sites in the city revolve around Twain and his writings, which occupy a prominent place in the history of the Underground Railroad era.
Doable as a same-day drive at 1h 44m. Total distance: 84.9 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
1h 44m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (0%). Some complex stretches to watch for.
Scenic Drive
Mostly surface roads route profile.
Frequently Asked Questions
The longest stretch is about 73.2 miles on Avenue of the Saints. The full list of main roads is in the Roads section above.
Yes. At under 2 hours behind the wheel, this works well for families — plan one quick stop if you have younger kids.
The main spots that need attention: at 3.8 miles (US 61 / Avenue of the Saints): Lane positioning matters here; at 77 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 77.5 miles (I 70 / Dwight D Eisenhower Highway): Merge point - match speed before joining. Lane positioning matters here.
Yes. A round trip is manageable in a single day if you plan a break at O'Fallon, MO before heading back.
