Connecting O'Fallon to Cameron, this 238.1-mile journey across Missouri takes approximately 4 hours and 47 minutes behind the wheel. Given the manageable duration, you can easily complete this trip in a single day without needing an overnight stay. Expect to spend about $36 on fuel, making this a cost-effective route for a weekend excursion or a straightforward relocation. You will traverse the heart of the Midwest, transitioning from the eastern edge of the state toward the northwestern region. Since this is a highway-focused drive, it serves as a reliable and efficient way to travel between these two points.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
119 miles from O'Fallon, MO
A natural place for your longest stop of the day
, about 2h 16m into the drive
.
Main Roads
Road
Distance
Duration
I 70
168 mi
3h 10m
MO 13
45.1 mi
1h 1m
Northeast Highway 69
13.1 mi
17m
West Elm Street
10.5 mi
13m
South Main Street
0.6 mi
1m
East 2nd Street
0.3 mi
1m
West Terra Lane
0.1 mi
<1m
West 2nd Street
—
—
Some road-level metrics are being recalculated.
Longest stretch:
I 70
— 168 mi, about 3h 10m
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon, MO and Cameron, MO.
1
Start on this road
25 ft·7 sec·this road
2
Turn left onto South Main Street
0.6 mi·1 min·South Main Street
3
Turn left
34 ft·6 sec
Toward I 70 EastUse the left lane.
4
Turn sharp left onto South Main Street
284 ft·11 sec·South Main Street
5
Turn left onto West Terra Lane
0.1 mi·12 sec·West Terra Lane
Use the left lane.
6
Take the ramp
479 ft·6 sec
Toward I 70 West
7
Merge onto I 70
168 mi·3 hr 10 min·I 70
Use the straight / slight right lanes.
8
Take the exit
0.2 mi·25 sec
Exit 49Toward MO 13: Higginsville, Warrensburg
9
Turn right onto MO 13
45 mi·1 hr 1 min·MO 13
10
Turn left onto MO 116
11 mi·13 min·West Elm Street
11
Enter roundabout onto US 69
22 ft·0 sec·Northeast Highway 69
12
Continue on US 69
13 mi·17 min·Northeast Highway 69
13
Turn left onto East 2nd Street
0.3 mi·1 min·East 2nd Street
14
Arrive at destination
West 2nd Street
Trip Plan
Planning for this 238.1-mile drive is simple, but keeping a few logistical details in mind will ensure a smoother experience. Since the route requires one planned stop, use that time to stretch your legs and refuel once you have cleared the initial 168-mile interstate stretch. Departing in the morning will help you avoid potential traffic congestion on the busier highway sections. Keep your $36 fuel budget handy, as monitoring your tank during the transition from I-70 to state routes is essential. Because the drive is under five hours, you have plenty of flexibility to adjust your departure time based on your personal schedule.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 119 miles from O'Fallon, MO, or about 2h 16m into the drive.
The longest continuous stretch on this route runs about 168 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 52 miles or 1h in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 119 miles or 2h 16m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 49m
Traffic, exits, and arrival timing usually matter more near Cameron, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving O'Fallon, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from O'Fallon, MO
This is one driving day of about 238.1 miles and 4h 47m.
Your first comfortable stop window is around 52 miles from O'Fallon, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 70 for about 168 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 11
5 decision points cluster between mile 0.6 and 168.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
0.6 mi into trip|~1m in
Turn left toward I 70 East
Lane positioning matters here
Use the left lane.
Toward I 70 East
6
0.6 mi into trip|~1m in|South Main Street
Turn sharp left onto South Main Street
Sharp turn - reduce speed on approach
6
0.7 mi into trip|~2m in|West Terra Lane
Turn left onto West Terra Lane
Lane positioning matters here
Use the left lane.
5
0.9 mi into trip|~2m in|I 70
Merge onto I 70
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
6
168.9 mi into trip|~3h 13m in
Take the exit toward MO 13: Higginsville, Warrensburg
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 49
Toward MO 13: Higginsville, Warrensburg
Fuel & Cost
Regular Gas
$37.22 one way
$74.45 round trip
$3.97/gal25.4 MPG avg83 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$40.87
$81.74
premium
$4.89
$45.82
$91.64
diesel
$5.61
$52.57
$105.14
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$37
Meals
$25–$50
Total
$62–$87
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 83.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $25 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
71.4
0
$25.00
$11.43
Efficient EV
59.5
0
$20.83
$9.52
EV Truck/SUV
95.2
1
$33.33
$15.24
Gas CO2
83 kg
EV CO2
28 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 14, 2026
Origin
O'Fallon, MO
Night
in O'Fallon on Saturday
Local time
9:44 PM
CDT
Current temp
69°F
Partly Cloudy
SW 14 mph9% chanceLive forecast
Destination
Cameron, MO
Night
in Cameron on Saturday
Local time
9:44 PM
CDT
Current temp
74°F
Unavailable
Live forecast
71°F
Marshall, MO
119 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 47m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
With 95% of the trip spent on highways, you should prepare for a consistent, high-speed pace. The route relies heavily on I-70, MO 13, and Northeast Highway 69 to move you efficiently across the landscape. You will face your longest uninterrupted stretch early on, covering 168 miles specifically on I-70. While the interstate sections prioritize speed and direct travel, transitioning onto state highways later in the drive offers a shift in rhythm. Expect a functional, road-focused experience that prioritizes reaching your destination steadily rather than winding through backroads.
95% highway — fuel and pacing are the main things to plan.
14 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 168 mi on I 70.
How Hard Is This Drive?
3/10
This is a straightforward highway drive that stays mostly on I 70 and MO 13. There are only a few real navigation decisions along the way. The trickiest moment comes around 0.6 miles in.
Driving Effort3/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 4h 47m drive. You will face about 11 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: at 0.6 miles: Lane positioning matters here; at 0.6 miles (South Main Street): Sharp turn - reduce speed on approach; at 0.7 miles (West Terra Lane): Lane positioning matters here.
Elevation Profile
Gently rolling terrain
1,015 ft546 ft
Total Climb
1,096 ft
Total Descent
626 ft
Highest Point
1,015 ft
~228.2 mi in
Elevation Range
469 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from O'Fallon, MO to Cameron, MO, road signs begin pointing toward Warrensburg along the way.
Warrensburg
168.9 mi in|~3h 13m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 47m. Total distance: 238.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
The longest stretch is about 168 miles on I 70. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: at 0.6 miles: Lane positioning matters here; at 0.6 miles (South Main Street): Sharp turn - reduce speed on approach; at 0.7 miles (West Terra Lane): Lane positioning matters here.
Possible but tiring. At 4.8 hours each way, an in-and-out day trip would put you behind the wheel for 9.6 hours — manageable with a long break at Cameron, MO, but most travelers stay overnight.
