Traveling from O'Fallon to Unionville covers 222.3 miles and typically takes about 4 hours and 32 minutes of drive time. Because this journey stays entirely within the Midwest region of Missouri, it is manageable as a single-day trip. You should budget approximately $34 for fuel to complete the trek. The route utilizes a combination of the Avenue of the Saints, North Missouri Street, and the Chicago-Kansas City Expressway. Since the drive is under five hours, you can comfortably complete it in one day without needing an overnight stay.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
111.1 miles from O'Fallon, MO
A natural place for your longest stop of the day
, about 2h 14m into the drive
.
Main Roads
Road
Distance
Duration
Avenue of the Saints
73.3 mi
1h 26m
North Missouri Street
54.4 mi
1h 4m
Chicago-Kansas City Expressway
52.9 mi
1h 1m
US 136
24.5 mi
36m
I 70
6.9 mi
8m
V.F.W. Memorial Highway
5.8 mi
6m
Veterans Road
2.2 mi
3m
South Main Street
0.6 mi
1m
Longest stretch:
Avenue of the Saints
— 73.3 mi, about 1h 26m
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon, MO and Unionville, MO.
1
Start on this road
25 ft·7 sec·this road
2
Turn left onto South Main Street
0.6 mi·1 min·South Main Street
3
Turn left
34 ft·6 sec
Toward I 70 EastUse the left lane.
4
Turn sharp left onto South Main Street
284 ft·11 sec·South Main Street
5
Turn left onto West Terra Lane
0.1 mi·12 sec·West Terra Lane
Use the left lane.
6
Take the ramp
479 ft·6 sec
Toward I 70 West
7
Merge onto I 70
6.9 mi·8 min·I 70
Use the straight / slight right lanes.
8
Take the exit
0.4 mi·47 sec
Exit 210BToward US 61 North: HannibalUse the slight right lane.
9
Merge onto US 61
73 mi·1 hr 26 min·Avenue of the Saints
Use the right lane.
10
Take the exit
249 ft·14 sec
11
Turn left onto Paris Gravel Road
0.5 mi·1 min·Paris Gravel Road
12
Keep slight right at fork onto County Road 422
279 ft·8 sec·County Road 422
13
Turn right onto Veterans Road
2.2 mi·3 min·Veterans Road
14
Take the ramp
0.2 mi·16 sec
Toward US 36 West, MO 110 West: Monroe City
15
Merge onto US 36; MO 110
5.8 mi·6 min·V.F.W. Memorial Highway
16
Continue on US 24; US 36; MO 110
53 mi·1 hr 1 min·Chicago-Kansas City Expressway
17
Take the exit
0.2 mi·28 sec
Toward US 63: Macon, Kirksville
18
Turn right onto US 63
54 mi·1 hr 4 min·North Missouri Street
19
Turn left onto US 136
24 mi·36 min·US 136
20
Arrive at destination
US 136
Trip Plan
To keep your 4-hour and 32-minute trip smooth, plan for at least one dedicated stop along the way to break up the drive. Since the route involves a mix of expressways and local streets, keep a close eye on your navigation as you transition between the Chicago-Kansas City Expressway and the local stretches. Leaving early in the day will help you avoid potential traffic fluctuations on the busier segments. Given the $34 fuel estimate, it is wise to fill your tank before you leave O'Fallon to ensure you have consistent coverage for the entire 222.3-mile distance. Flexibility is your best asset here, so feel free to adjust your stop timing based on your personal comfort during that 73.3-mile stretch on the Avenue of the Saints.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 111.1 miles from O'Fallon, MO, or about 2h 14m into the drive.
The longest continuous stretch on this route runs about 73.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 49 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 111.1 miles or 2h 14m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 38m
Traffic, exits, and arrival timing usually matter more near Unionville, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving O'Fallon, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from O'Fallon, MO
This is one driving day of about 222.3 miles and 4h 32m.
Your first comfortable stop window is around 49 miles from O'Fallon, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Avenue of the Saints for about 73.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 17
5 decision points cluster between mile 0.6 and 84.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
0.6 mi into trip|~1m in
Turn left toward I 70 East
Lane positioning matters here
Use the left lane.
Toward I 70 East
6
0.6 mi into trip|~1m in|South Main Street
Turn sharp left onto South Main Street
Sharp turn - reduce speed on approach
6
0.7 mi into trip|~2m in|West Terra Lane
Turn left onto West Terra Lane
Lane positioning matters here
Use the left lane.
7
7.8 mi into trip|~10m in
Take the exit toward US 61 North: Hannibal
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 210B
Toward US 61 North: Hannibal
6
84.3 mi into trip|~1h 43m in
Take the ramp toward US 36 West, MO 110 West: Monroe City
Multiple destination signs - pick the right one
Toward US 36 West, MO 110 West: Monroe City
Fuel & Cost
Regular Gas
$34.75 one way
$69.51 round trip
$3.97/gal25.4 MPG avg78 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$38.16
$76.32
premium
$4.89
$42.78
$85.56
diesel
$5.61
$49.08
$98.16
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$35
Meals
$25–$50
Total
$60–$85
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 77.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $23 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
66.7
0
$23.34
$10.67
Efficient EV
55.6
0
$19.45
$8.89
EV Truck/SUV
88.9
1
$31.12
$14.23
Gas CO2
78 kg
EV CO2
26 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
O'Fallon, MO
Night
in O'Fallon on Saturday
Local time
9:47 PM
CDT
Current temp
57°F
Unavailable
Live forecast
Destination
Unionville, MO
Night
in Unionville on Saturday
Local time
9:47 PM
CDT
Current temp
78°F
Unavailable
Live forecast
71°F
Bowling Green, MO
111 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
21 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 32m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This trip offers a mixed driving profile, balancing high-speed highway segments with local road segments. Highway travel makes up 38% of the journey, providing a solid pace for a significant portion of your time behind the wheel. You will encounter your longest stretch of continuous driving on the Avenue of the Saints, which spans 73.3 miles. Expect the road character to shift as you transition between these major arteries and smaller connectors. The drive is straightforward, though you should be prepared for the varying road types that define this cross-state path.
38% highway, the rest on surface roads — varied driving throughout.
20 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 73.3 mi on Avenue of the Saints.
How Hard Is This Drive?
6/10
This route mixes highway mileage with some local-road sections near the start or finish. You will hit about 17 points where you need to pay attention to lane position or signs. The trickiest moment comes around 0.6 miles in.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 222.3 miles you will encounter 17 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 0.6 miles: Lane positioning matters here; at 0.6 miles (South Main Street): Sharp turn - reduce speed on approach; at 0.7 miles (West Terra Lane): Lane positioning matters here.
Elevation Profile
Mostly flat terrain
1,062 ft485 ft
Total Climb
980 ft
Total Descent
464 ft
Highest Point
1,062 ft
~222.3 mi in
Elevation Range
577 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from O'Fallon, MO to Unionville, MO, road signs begin pointing toward Kirksville along the way.
Kirksville
143.2 mi in|~2h 51m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 32m. Total distance: 222.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 32m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile.
Frequently Asked Questions
The longest stretch is about 73.3 miles on Avenue of the Saints. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Unionville, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 0.6 miles: Lane positioning matters here; at 0.6 miles (South Main Street): Sharp turn - reduce speed on approach; at 0.7 miles (West Terra Lane): Lane positioning matters here.
Possible but tiring. At 4.5 hours each way, an in-and-out day trip would put you behind the wheel for 9.1 hours — manageable with a long break at Unionville, MO, but most travelers stay overnight.
