Madison, MS to Biloxi, MS is 176.4 miles and takes about 3h 38m via Highway 49 South/US 49, with a fuel budget near $27 and enough daylight to finish in a day. This trip stays within Mississippi, moving from the Southeast region to the Southeast region. For the most part, you'll be on highways, making for a straightforward drive. With a recommended one-day trip duration, it's a manageable distance for a single day's travel, especially considering the estimated fuel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
88.2 miles from Madison, MS
A natural place for your longest stop of the day
, about 1h 50m into the drive
.
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
US 49
44.1 mi
53m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
I 55
8.2 mi
10m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
United States Highway 51
4.4 mi
6m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Turn-by-Turn Driving Directions
Step-by-step road directions between Madison, MS and Biloxi, MS.
1
Start on Depot Drive
36 ft·7 sec·Depot Drive
2
Turn left onto Main Street
0.2 mi·34 sec·Main Street
3
Turn right onto US 51
4.4 mi·6 min·United States Highway 51
4
Turn left onto I-55 Frontage Road
0.3 mi·28 sec·I-55 Frontage Road
5
Continue on I- 55 North Frontage Road
442 ft·7 sec·I- 55 North Frontage Road
6
Take the ramp
0.2 mi·31 sec
7
Merge onto I 55
8.2 mi·10 min·I 55
8
Take the exit
0.9 mi·1 min
Toward I 20 East, US 49 South: Meridian, Hattiesburg
9
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
10
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
11
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
12
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
13
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
14
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
15
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
16
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
17
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
18
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
19
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
20
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
21
Continue on I 110
3.2 mi·4 min·I 110
22
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
23
Turn left onto Division Street
0.6 mi·1 min·Division Street
24
Turn right onto Main Street
0.5 mi·1 min·Main Street
25
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
26
Arrive at destination
Howard Avenue
Trip Plan
Given that this is a 1-day trip covering 176.4 miles, you have plenty of flexibility for when you depart. Leaving in the morning will allow you to reach Biloxi with ample time to spare. Keep an eye on your fuel gauge, as the estimated cost is around $27, and it's always wise to fill up before the longest stretch of highway. The route primarily uses Highway 49 South and US 49, so plan your stops accordingly, perhaps around the halfway point or before you hit the most concentrated exit areas near the coast.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 88.2 miles from Madison, MS, or about 1h 50m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 39 miles or 50m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 88.2 miles or 1h 50m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 57m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Madison, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Madison, MS
This is one driving day of about 176.4 miles and 3h 38m.
Your first comfortable stop window is around 39 miles from Madison, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 18
5 decision points cluster between mile 14.4 and 108.5 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
14.4 mi into trip|~19m in|US 49
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Richland, Hattiesburg
7
96.9 mi into trip|~2h 1m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
105 mi into trip|~2h 10m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
108.2 mi into trip|~2h 14m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
108.5 mi into trip|~2h 15m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Fuel & Cost
Regular Gas
$26.64 one way
$53.28 round trip
$3.84/gal25.4 MPG avg62 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$29.24
$58.49
premium
$4.56
$31.66
$63.32
diesel
$5.61
$38.95
$77.89
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$27
Meals
$25–$50
Total
$52–$77
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 61.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
24 DC fast chargers
· Coverage: excellent
North Bus Barn
Jackson, MS
NOODOE
14 DCFC
South Bus Barn
Jackson, MS
NOODOE
12 DCFC
Lakeview Village Shopping Mall - Tesla Supercharger
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $19 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
52.9
0
$18.52
$8.47
Efficient EV
44.1
0
$15.43
$7.06
EV Truck/SUV
70.6
0
$24.70
$11.29
Gas CO2
62 kg
EV CO2
21 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Madison, MS
Late night
in Madison on Sunday
Local time
2:48 AM
CDT
Current temp
79°F
Unavailable
Live forecast
Destination
Biloxi, MS
Late night
in Biloxi on Sunday
Local time
2:48 AM
CDT
Current temp
61°F
Unavailable
Live forecast
58°F
Sumrall, MS
88 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
18 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 38m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~10 min detour
Free
near mile 12.2
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This drive is largely highway, with 93% of it on major roads. You'll experience an 80.3-mile stretch on Highway 49 South, indicating a significant portion of uninterrupted driving. The profile is mostly highway, suggesting a consistent cruising experience with fewer turns until you approach Biloxi. Expect a dense network of exits as you get closer to your destination.
93% highway — fuel and pacing are the main things to plan.
26 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80.3 mi on Highway 49 South.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Highway 49 South and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 14.4 miles in near US 49.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 176.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 14.4 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 96.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 105 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Madison, MS and Biloxi, MS, road signs point toward Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast, Mobile and Gulfport - among others.
Hattiesburg
13.4 mi in|~18m
Richland
14.4 mi in|~19m|via US 49
Gulf Coast
96.9 mi in|~2h 1m
Mississippi Gulf Coast
97.2 mi in|~2h 1m|via I 59
Mobile
105 mi in|~2h 10m|via US 98
Gulfport
108.2 mi in|~2h 14m
Multi Purpose Center
108.5 mi in|~2h 15m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 3h 38m. Total distance: 176.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 38m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (93%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 80.3 miles on Highway 49 South. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Biloxi, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 14.4 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 96.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 105 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Possible but tiring. At 3.6 hours each way, an in-and-out day trip would put you behind the wheel for 7.3 hours — manageable with a long break at Biloxi, MS, but most travelers stay overnight.
