Biloxi to Greenville is 282.5 miles and takes about 5h 52m via US 49, with a fuel budget near $45 and enough daylight to finish in a day. This trip stays within Mississippi, moving from the Southeast region to the same region. Expect a straightforward drive for the most part, primarily on major highways. With a recommended one-day drive, you'll have ample time to reach your destination without feeling rushed.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
141.3 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 2h 55m into the drive
.
Main Roads
Road
Distance
Duration
US 49
140.6 mi
2h 53m
US 49W
46.7 mi
56m
Medgar Evers Boulevard
39.5 mi
48m
MS 15
20.7 mi
24m
US 82
15.8 mi
19m
MS 182
9.2 mi
13m
I 20
4.3 mi
5m
I 110
3.1 mi
4m
Longest stretch:
US 49
— 140.6 mi, about 2h 53m
Traffic on I-20
Hour-of-day weekday pattern from 14 FHWA count stations on your route.
Peak
7 AM
~2,710 veh/hr typical
· worst 4,827
Quietest
2 AM
~220 veh/hr
Peak-to-quiet ratio
12.3×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 51 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Greenville, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
17
Take the exit onto US 49
0.2 mi·21 sec·US 49
18
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
19
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
20
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
21
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
22
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
23
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
24
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
25
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
26
Turn left onto US 82
2.4 mi·3 min·US 82
27
Keep slight left at fork onto US 82
0.4 mi·29 sec·US 82
28
Keep slight left at fork onto US 82
13 mi·15 min·US 82
29
Turn right onto MS 182
9.2 mi·13 min·MS 182
30
Turn right onto South Main Street
0.9 mi·2 min·South Main Street
31
Turn right onto MS 814
10 ft·0 sec·South Broadway Street
32
Arrive at destination
MS 814
Trip Plan
Given the 5h 52m estimated drive time, leaving Biloxi in the morning is ideal to maximize daylight. The route is designed for a single day, so plan for one main stop to break up the 140.6-mile highway segment. Keep an eye on your fuel gauge, especially as you approach the end of the highway portion, as services might become less frequent. The $45 fuel cost is an estimate, so check current prices before you depart.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 141.3 miles from Biloxi, MS, or about 2h 55m into the drive.
The longest continuous stretch on this route runs about 140.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 62 miles or 1h 15m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 141.3 miles or 2h 55m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 47m
Traffic, exits, and arrival timing usually matter more near Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 282.5 miles and 5h 52m.
Your first comfortable stop window is around 62 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 140.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 21
5 decision points cluster between mile 25.1 and 164.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
158.9 mi into trip|~3h 17m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
6
162.2 mi into trip|~3h 21m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
5
164.9 mi into trip|~3h 25m in|US 49
Take the exit onto US 49 toward I 220 North, I 49 North: North Jackson, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 220 North, I 49 North: North Jackson,...
Fuel & Cost
Regular Gas
$39.22 one way
$78.43 round trip
$3.53/gal25.4 MPG avg99 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$3.95
$43.88
$87.75
premium
$4.29
$47.70
$95.40
diesel
$4.80
$53.34
$106.68
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$39
Meals
$25–$50
Total
$64–$89
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 98.8 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $30 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
84.8
1
$29.66
$13.56
Efficient EV
70.6
0
$24.72
$11.30
EV Truck/SUV
113
1
$39.55
$18.08
Gas CO2
99 kg
EV CO2
33 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 18, 2026
Origin
Biloxi, MS
Late night
in Biloxi on Sunday
Local time
3:14 AM
CDT
Current temp
79°F
Mostly Clear
NW 5 mph3% chanceLive forecast
Destination
Greenville, MS
Late night
in Greenville on Sunday
Local time
3:14 AM
CDT
Current temp
76°F
Partly Cloudy
0 mph3% chanceLive forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 52m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~9 min detour
Free
near mile 165.6
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This drive is 85% highway, meaning you'll spend most of your time on high-speed roads. The longest continuous stretch on a highway is 140.6 miles on US 49. You'll transition to surface roads for the final portion of the trip. Expect a steady pace with fewer turns for the majority of the journey.
85% highway — fuel and pacing are the main things to plan.
32 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 140.6 mi on US 49.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 21 significant decision points across 282.5 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Elevation Profile
Mostly flat terrain
440 ft20 ft
Total Climb
542 ft
Total Descent
435 ft
Highest Point
440 ft
~121.1 mi in
Elevation Range
419 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Greenville, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Jackson
25.1 mi in|~32m
Yazoo City
162.2 mi in|~3h 21m|via I 20; US 49
Vicksburg
209.9 mi in|~4h 20m|via US 49W
Detours Along the Way
Tagged by where each one fits in your drive — first break, midpoint, final stretch.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Top landmarks
•Jefferson Davis Presidential Library and Museum — presidential library and museum for Confederate States President Jefferson Davis...
•Beauvoir — post-war home of the former President of the Confederate States of America, Jeff...
•Biloxi Light — lighthouse in Mississippi, United States
Greenville is a city in Washington County, Mississippi, United States. The population was 30,000 in 2020, making it the ninth largest city in the state. It is the county seat of Washington County.
Top landmarks
•Doe's Eat Place — restaurant in Greenville, Mississippi, United States
•First National Bank of Greenville — historic building in Greenville, Mississippi
•Washington County Courthouse — Courthouse in Greenville, Mississippi
Doable as a same-day drive at 5h 52m. Total distance: 282.5 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 52m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (85%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 140.6 miles on US 49. The full list of main roads is in the Roads section above.
Yes — we found about 11 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Greenville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 11 rest areas along the route for bathroom stops.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.9 hours each way, a round trip means 11.8 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Greenville, MS before the return drive.
