Trip from Greenville, MS to Vancleave, MS

Compiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Apr 18, 2026 · Editorial standards

Drive Time

6h 6m

Distance

298 mi

480 km

Drive Score

9/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$45

one way

EV Charging

Sparse

1 stations

Best Time to Leave

Save up to 39 min

4 AM

5h 54m ★

6 AM

6h 7m

8 AM

6h 33m

10 AM

6h 16m

12 PM

6h 13m

3 PM

6h 17m

5 PM

6h 31m

8 PM

5h 59m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly

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Greenville, MS

Wikimedia Commons

Vancleave, MS

Galina Yarovaya.

Trip Overview

Embarking on this 298-mile journey from Greenville, MS, to Vancleave, MS, will take you approximately 6 hours and 6 minutes of driving time. This route is best suited for a single day trip, allowing you to reach your destination without needing an overnight stop. The estimated fuel cost for this drive is around $46, making it a budget-friendly option. You'll primarily be navigating local roads, with a significant portion involving turns, so be prepared for a more engaged driving experience. This trip keeps you within the Southeast region, offering a consistent regional feel throughout your travels.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

149 miles from Greenville, MS

A natural place for your longest stop of the day , about 3h 6m into the drive .

Main Roads

Road	Distance	Duration
Highway 49 South	80.3 mi	1h 37m
US 49	53.4 mi	1h 4m
North Martin Luther King Drive	46.2 mi	55m
Jerry Clower Boulevard	38.8 mi	47m
Biloxi-D'Iberville Scenic Expressway	20.5 mi	24m
US 82	15.8 mi	19m
I 10	10.4 mi	11m
MS 182	9.2 mi	13m

Longest stretch: Highway 49 South — 80.3 mi, about 1h 37m

Turn-by-Turn Driving Directions

Step-by-step road directions between Greenville, MS and Vancleave, MS.

Start on MS 814

10 ft · 7 sec · South Broadway Street

Turn left onto Main Street

0.9 mi · 2 min · Main Street

Turn left onto MS 182

9.2 mi · 13 min · MS 182

Turn left onto US 82; US 278

16 mi · 19 min · US 82; US 278

Use the straight lane.

Turn right onto US 49W

46 mi · 55 min · North Martin Luther King Drive

Keep slight right at fork onto US 49W

0.5 mi · 53 sec · US 49W

Toward US 49 South: Jackson

Merge onto US 49

39 mi · 47 min · Jerry Clower Boulevard

Take the exit onto US 49

4.9 mi · 5 min · US 49

Keep slight left at fork onto US 49

3.8 mi · 5 min · US 49

Merge onto I 20; I 55; US 49

1.1 mi · 1 min · I 20; I 55; US 49

Keep slight right at fork onto I 20; US 49

347 ft · 4 sec · I 20; US 49

Toward Meridian, Hattiesburg

Take the exit onto US 49

0.6 mi · 42 sec · US 49

Toward Hattiesburg

Keep slight right at fork onto US 49

0.7 mi · 1 min · US 49

Toward Richland, Hattiesburg

Merge onto US 49

80 mi · 1 hr 37 min · Highway 49 South

Use the straight lane.

Continue on US 49; MS 42

0.4 mi · 35 sec · US 49; MS 42

Use the straight lane.

Continue on US 49; MS 42

1.1 mi · 1 min · US 49; MS 42

Use the straight lane.

Take the exit

0.4 mi · 36 sec

Toward I 59 South: New Orleans, Gulf Coast Use the slight right lane.

Merge onto I 59

7.7 mi · 8 min · Lance Corporal Roy M Wheat Memorial Highway

Toward Mississippi Gulf Coast Use the straight lane.

Take the exit onto US 98

3.2 mi · 4 min · US 98

Toward US 98 East: Lucedale, Mobile Use the straight / slight right lanes.

Take the exit

0.3 mi · 44 sec

Toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast Use the straight / slight right lanes.

Keep slight left at fork

0.2 mi · 27 sec

Toward Multi Purpose Center, Hattiesburg Use the slight left / slight right lanes.

Turn right onto US 49

42 mi · 49 min · US 49

Use the straight lane.

Take the exit

0.8 mi · 1 min

Toward MS 67 South: D'Iberville, Biloxi

Continue on MS 67

20 mi · 24 min · Biloxi-D'Iberville Scenic Expressway

Continue on I 110

0.1 mi · 10 sec · I 110

Take the exit

0.3 mi · 46 sec

Exit 4A Toward I 10 East: Pascagoula, Mobile

Keep slight left at fork

0.2 mi · 31 sec

Toward I 10

Merge onto I 10

10 mi · 11 min · I 10

Take the exit

0.2 mi · 31 sec

Toward MS 57: Vancleave, Gautier, Ocean Springs

Keep slight left at fork

93 ft · 4 sec

Turn left onto MS 57

7.5 mi · 10 min · MS 57

Arrive at destination

MS 57

Trip Plan

For this 6-hour drive, consider an early morning departure from Greenville to maximize daylight and allow for a comfortable pace. With only one recommended stop, you have flexibility in deciding when and where to take a break. Keep an eye on your fuel gauge, as the $46 estimated cost covers the entire trip, and it's wise to top off before leaving Greenville or at a point where you know services are available along US 49 South. Be mindful of the 'turn-heavy' nature of this route and plan for slightly longer travel times than a direct highway route might suggest.

Morning Departure

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Evening Departure

This is a long drive — plan for a morning departure or consider splitting it into two days.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 149 miles from Greenville, MS, or about 3h 6m into the drive.

The longest continuous stretch on this route runs about 80.3 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 66 miles or 1h 23m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 149 miles or 3h 6m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 5h 1m

Traffic, exits, and arrival timing usually matter more near Vancleave, MS than in the middle of the route.

Before You Leave

Open the route before leaving Greenville, MS so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Greenville, MS

This is one driving day of about 298 miles and 6h 6m.

Your first comfortable stop window is around 66 miles from Greenville, MS.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

The longest stretch is on Highway 49 South for about 80.3 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Mid-route town

Meal stop

Brandon, MS

149 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Yazoo City, MS

Fuel and coffee

A short stop after about 66 miles helps settle the day before fatigue starts building.

Florence, MS

Meal break

The midpoint is around 149 miles from Greenville, MS, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before Highway 49 South if your tank is already low. That segment runs about 80.3 miles.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Nearby Places

Restaurants, cafes, gas stations and more along your route.

Top Restaurant

Bougie Coffee Company

4.8 ★ ★ ★ ★ ★

Florence, Mississippi

Around the midpoint, short detour

1.4 mi from route ~4 min detour $1 to $10 mile 127.7

Hours: 6 am–5 pm

+16017159972

Visit website

Top Coffee Stop

The Espresso Bar

4.8 ★ ★ ★ ★ ★

Richland, Mississippi

Around the midpoint, short detour

1.8 mi from route ~5 min detour $1 to $10 mile 127.7

Hours: 6 am–5 pm

+17692358869

Bougie Coffee Company

4.8 ★ ★ ★ ★ ★

Around the midpoint, short detour

1.4 mi from route ~4 min detour $1 to $10 mile 127.7

Florence, Mississippi

Hours: 6 am–5 pm

+16017159972

Visit website

Sonic Drive-In

4.1 ★ ★ ★ ★ ☆

Near the start, ~10 min detour

3.9 mi from route ~10 min detour Inexpensiv mile 21.3

Indianola, Mississippi

Hours: 7 am–10 pm

+16628872929

Visit website

Roma Italian Restaurant

4.6 ★ ★ ★ ★ ★

Around the midpoint, ~12 min detour

5 mi from route ~12 min detour $20 to $30 mile 106.4

Clinton, Mississippi

Hours: 11 am–9 pm

+16014884850

Visit website

The Espresso Bar

4.8 ★ ★ ★ ★ ★

Around the midpoint, short detour

1.8 mi from route ~5 min detour $1 to $10 mile 127.7

Richland, Mississippi

Hours: 6 am–5 pm

+17692358869

ChargePoint Charging Station

Near the end, short detour

2.6 mi from route ~7 min detour mile 276.7

D'Iberville, Mississippi

Hours: Open 24 hours

+18887584389

Visit website

Place data sourced from public business listings. Hours and availability may vary.

Heads-up: tricky spots

5 of 24

5 decision points cluster between mile 121.2 and 215.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.

121.2 mi into trip | ~2h 32m in | I 20; US 49

Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg

Highway fork - watch signs carefully. Multiple destination signs - pick the right one

Toward Meridian, Hattiesburg

204.3 mi into trip | ~4h 14m in

Take the exit toward I 59 South: New Orleans, Gulf Coast

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Toward I 59 South: New Orleans, Gulf Coast

212.4 mi into trip | ~4h 23m in | US 98

Take the exit onto US 98 toward US 98 East: Lucedale, Mobile

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the straight / slight right lanes. Toward US 98 East: Lucedale, Mobile

215.6 mi into trip | ~4h 27m in

Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the straight / slight right lanes. Toward US 49: Wiggins, Gulfport, Mississippi Gu...

215.9 mi into trip | ~4h 28m in

Keep slight left at fork toward Multi Purpose Center, Hattiesburg

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left / slight right lanes. Toward Multi Purpose Center, Hattiesburg

Fuel & Cost

Regular Gas

$45.01 one way

$90.01 round trip

$3.84/gal 25.4 MPG avg 104 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.21	$49.40	$98.81
premium	$4.56	$53.49	$106.97
diesel	$5.61	$65.79	$131.59

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$45

Meals

$25–$50

Total

$70–$95

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 104.3 kg one way. Prices: EIA weekly data, 2026-04-13.

Driving Electric?

About $31 in charging · 1 stop · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	89.4	1	$31.29	$14.30
Efficient EV	74.5	0	$26.08	$11.92
EV Truck/SUV	119.2	1	$41.72	$19.07

Gas CO2

104 kg

EV CO2

35 kg (66% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast as of Apr 15, 2026

Origin

Greenville, MS

Evening in Greenville on Saturday

Local time

8:26 PM

CDT

Current temp

77°F

Unavailable

Live forecast

Destination

Vancleave, MS

Evening in Vancleave on Saturday

Local time

8:26 PM

CDT

Current temp

61°F

Unavailable

Live forecast

61°F

Brandon, MS

149 mi in

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

16 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

6h 6m on the road

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

What kind of drive is this?

This is a turn-heavy local drive, meaning you won't encounter long stretches of high-speed highway; in fact, the highway share is 0%. Instead, expect a more engaging experience as you navigate through communities on roads like Main Street and North Martin Luther King Drive before transitioning to US 49 South. With no long uninterrupted stretches noted, you'll likely find yourself making frequent adjustments, keeping you actively involved in the driving process. The profile suggests a continuous shift in scenery and road conditions as you make your way across Mississippi.

68% highway — fuel and pacing are the main things to plan.

32 navigation steps total — most of the decisions cluster near the start and finish.

Longest single stretch: 80.3 mi on Highway 49 South.

How Hard Is This Drive?

10/10

This is a straightforward highway drive that stays mostly on Highway 49 South and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 121.2 miles in near I 20; US 49.

Driving Effort 10/10

High effort - long or complex enough to need steady focus all day

Balances navigation complexity with total wheel time.

This is a demanding drive. With 24 significant decision points across 298 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 204.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 212.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.

Towns Mentioned on Route Signs

Based on OSRM destination-sign hints, not a full list of every settlement the road passes.

Between Greenville, MS and Vancleave, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Mobile - among others.

Meridian

121.2 mi in | ~2h 32m | via I 20; US 49

Hattiesburg

121.2 mi in | ~2h 32m | via I 20; US 49

Richland

121.8 mi in | ~2h 32m | via US 49

Gulf Coast

204.3 mi in | ~4h 14m

Mississippi Gulf Coast

204.7 mi in | ~4h 14m | via I 59

Mobile

212.4 mi in | ~4h 23m | via US 98

Gulfport

215.6 mi in | ~4h 27m

Multi Purpose Center

215.9 mi in | ~4h 28m

Biloxi

258 mi in | ~5h 17m

Who Is This Route For?

Weekend Trip

Doable as a same-day drive at 6h 6m. Total distance: 298 miles.

Family Friendly

Moderate complexity with 1 natural rest stops along the way.

Solo Traveler

6h 6m drive, plan rest stops for pacing.

Frequently Asked Questions

The longest stretch is about 80.3 miles on Highway 49 South. The full list of main roads is in the Roads section above.

We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.

It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Vancleave, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.

Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.

Not recommended in a single day. At 6.1 hours each way, a round trip means 12.2 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Vancleave, MS before the return drive.

How this page is built

Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, and EIA for fuel prices. See our methodology for refresh cadence and limitations.

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Trip from Greenville, MS to Vancleave, MS

Best Time to Leave

Trip Overview

Main Roads

Turn-by-Turn Driving Directions

Trip Plan

Before You Leave

Where to Stop

Pacing Suggestions

Nearby Places

Bougie Coffee Company

The Espresso Bar

Bougie Coffee Company

Sonic Drive-In

Roma Italian Restaurant

The Espresso Bar

ChargePoint Charging Station

Heads-up: tricky spots

Fuel & Cost

Travel Intel

Greenville, MS

Vancleave, MS

Same local time

16 degrees cooler at arrival

6h 6m on the road

What kind of drive is this?

How Hard Is This Drive?

Towns Mentioned on Route Signs

Who Is This Route For?

Frequently Asked Questions

Which road carries most of the drive?

Are there rest areas on this route?

Should I avoid arriving after dark?

Is this a good trip with kids?

Where does this route get tricky?

Can I do this as a round trip in one go?

How this page is built

Explore More

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