Greenville, MS to D'Iberville, MS is 281.4 miles and takes about 5h 46m via Highway 49 South and US 49, with a fuel budget near $42 and enough daylight to finish in a day. This drive stays within Mississippi, traversing the Southeast region. It's a straightforward trip that primarily uses major highways, making it a practical option for a single-day journey. You'll find it's a functional route with no major scenic detours, ideal if your priority is reaching your destination efficiently.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
140.7 miles from Greenville, MS
A natural place for your longest stop of the day
, about 2h 56m into the drive
.
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
US 49
53.4 mi
1h 4m
North Martin Luther King Drive
46.2 mi
55m
Jerry Clower Boulevard
38.8 mi
47m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
US 82
15.8 mi
19m
MS 182
9.2 mi
13m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Traffic on I-20
Hour-of-day weekday pattern from 28 FHWA count stations on your route.
Peak
7 AM
~3,273 veh/hr typical
· worst 5,355
Quietest
2 AM
~278 veh/hr
Peak-to-quiet ratio
11.8×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 103 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenville, MS and D'Iberville, MS.
1
Start on MS 814
10 ft·7 sec·South Broadway Street
2
Turn left onto Main Street
0.9 mi·2 min·Main Street
3
Turn left onto MS 182
9.2 mi·13 min·MS 182
4
Turn left onto US 82; US 278
16 mi·19 min·US 82; US 278
Use the straight lane.
5
Turn right onto US 49W
46 mi·55 min·North Martin Luther King Drive
6
Keep slight right at fork onto US 49W
0.5 mi·53 sec·US 49W
Toward US 49 South: Jackson
7
Merge onto US 49
39 mi·47 min·Jerry Clower Boulevard
8
Take the exit onto US 49
4.9 mi·5 min·US 49
9
Keep slight left at fork onto US 49
3.8 mi·5 min·US 49
10
Merge onto I 20; I 55; US 49
1.1 mi·1 min·I 20; I 55; US 49
11
Keep slight right at fork onto I 20; US 49
347 ft·4 sec·I 20; US 49
Toward Meridian, Hattiesburg
12
Take the exit onto US 49
0.6 mi·42 sec·US 49
Toward Hattiesburg
13
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
14
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
15
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
16
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
17
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
18
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
19
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
20
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
21
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
22
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
23
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
24
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
25
Continue on I 110
1.4 mi·1 min·I 110
26
Take the exit
0.2 mi·24 sec
Exit 2Toward D'Iberville
27
Keep slight left at fork
189 ft·6 sec
28
Turn left onto Rodriguez Street
0.3 mi·50 sec·Rodriguez Street
29
Turn right onto Central Avenue
0.2 mi·42 sec·Central Avenue
30
Turn left onto Race Track Road
63 ft·1 sec·Race Track Road
31
Arrive at destination
Race Track Road
Trip Plan
For this 5h 46m drive, leaving in the morning is recommended to maximize daylight and allow for a relaxed pace. With only one recommended stop, you can plan to break up the 281.4 miles as needed, perhaps around the halfway point. Keep an eye on your fuel gauge, especially during the 80.3-mile stretch on Highway 49 South, as services might be less frequent in those areas. The estimated fuel cost is around $42, so budget accordingly. This route is well within a single day's driving time, offering flexibility for departure and arrival.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 140.7 miles from Greenville, MS, or about 2h 56m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 62 miles or 1h 19m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 140.7 miles or 2h 56m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 45m
Traffic, exits, and arrival timing usually matter more near D'Iberville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenville, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenville, MS
This is one driving day of about 281.4 miles and 5h 46m.
Your first comfortable stop window is around 62 miles from Greenville, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 24
5 decision points cluster between mile 121.2 and 215.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
121.2 mi into trip|~2h 32m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Meridian, Hattiesburg
7
204.3 mi into trip|~4h 14m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
212.4 mi into trip|~4h 23m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
215.6 mi into trip|~4h 27m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
215.9 mi into trip|~4h 28m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Fuel & Cost
Regular Gas
$43.03 one way
$86.06 round trip
$3.88/gal25.4 MPG avg99 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.33
$47.94
$95.88
premium
$4.73
$52.39
$104.78
diesel
$5.87
$65.05
$130.11
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$43
Meals
$25–$50
Total
$68–$93
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 98.5 kg one way.
Driving Electric?
About $30 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
84.4
1
$29.55
$13.51
Efficient EV
70.4
0
$24.62
$11.26
EV Truck/SUV
112.6
1
$39.40
$18.01
Gas CO2
98 kg
EV CO2
33 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 19, 2026
Origin
Greenville, MS
Late night
in Greenville on Thursday
Local time
5:34 AM
CDT
Current temp
48°F
Mostly Clear
E 10 mph0% chanceLive forecast
Destination
D'Iberville, MS
Late night
in D'Iberville on Thursday
Local time
5:34 AM
CDT
Current temp
50°F
Mostly Clear
NE 10 mph0% chanceLive forecast
50°F
Brandon, MS
141 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 46m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~10 min detour
Free
near mile 116.4
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is mostly highway, with 66% of the drive on roads like Highway 49 South and US 49. Expect an 80.3-mile stretch on Highway 49 South without needing to exit. The latter part of the drive will transition from highway to surface roads, likely with more local traffic as you approach D'Iberville. You'll notice increasing density of exits and intersections as you get closer to your destination.
66% highway — fuel and pacing are the main things to plan.
31 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80.3 mi on Highway 49 South.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Highway 49 South and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 121.2 miles in near I 20; US 49.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 24 significant decision points across 281.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 204.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 212.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
423 ft14 ft
Total Climb
443 ft
Total Descent
555 ft
Highest Point
423 ft
~160.8 mi in
Elevation Range
408 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Greenville, MS and D'Iberville, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Mobile - among others.
Greenville is a city in Washington County, Mississippi, United States. The population was 30,000 in 2020, making it the ninth largest city in the state. It is the county seat of Washington County.
Top landmarks
•Doe's Eat Place — restaurant in Greenville, Mississippi, United States
•First National Bank of Greenville — historic building in Greenville, Mississippi
•Washington County Courthouse — Courthouse in Greenville, Mississippi
Doable as a same-day drive at 5h 46m. Total distance: 281.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 46m drive, comfortable solo distance.
Frequently Asked Questions
The longest stretch is about 80.3 miles on Highway 49 South. The full list of main roads is in the Roads section above.
Yes — we found about 12 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at D'Iberville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 12 rest areas along the route for bathroom stops.
The main spots that need attention: at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 204.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 212.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.8 hours each way, a round trip means 11.6 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at D'Iberville, MS before the return drive.
