Traveling from Bay Saint Louis to Greenville covers 290.6 miles across the state of Mississippi, typically taking about 6 hours and 6 minutes of driving time. Because this route stays within the Southeast region, you will experience a consistent cultural backdrop as you head north. It is entirely feasible to complete this journey in a single day, as it is designed for a one-day trip with only one recommended stop along the way. Expect to budget roughly $44 for fuel, depending on your vehicle's efficiency. This highway-focused path provides a straightforward connection between the Gulf Coast and the Mississippi Delta, making it a functional choice for travelers who prefer direct transit over a multi-day excursion.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
145.3 miles from Bay Saint Louis, MS
A natural place for your longest stop of the day
, about 3h 4m into the drive
.
Main Roads
Road
Distance
Duration
US 49
89.3 mi
1h 49m
US 49W
46.7 mi
56m
I 59
40.4 mi
43m
Medgar Evers Boulevard
39.5 mi
48m
MS 43
24.9 mi
36m
US 82
15.8 mi
19m
MS 53
15.6 mi
23m
MS 182
9.2 mi
13m
Longest stretch:
US 49
— 89.3 mi, about 1h 49m
Turn-by-Turn Driving Directions
Step-by-step road directions between Bay Saint Louis, MS and Greenville, MS.
1
Start on South 2nd Street
0.2 mi·32 sec·South 2nd Street
2
Turn left onto Main Street
1.1 mi·1 min·Main Street
3
Turn left onto US 90
2.0 mi·2 min·US 90
Use the left lane.
4
Turn slight right
371 ft·12 sec
5
Continue on MS 43; MS 603
25 mi·36 min·MS 43; MS 603
6
Continue on MS 53
16 mi·23 min·MS 53
7
Take the ramp
0.2 mi·33 sec
8
Merge onto I 59
40 mi·43 min·I 59
Use the straight / slight right lanes.
9
Take the exit
0.2 mi·38 sec
Toward US 49 North, MS 42 West: JacksonUse the slight right lane.
10
Continue on US 49
1.2 mi·1 min·US 49
Use the straight lane.
11
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
12
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
13
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
14
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
15
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
16
Take the exit onto US 49
0.2 mi·21 sec·US 49
17
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
18
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
19
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
20
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
21
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
22
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
23
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
24
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
25
Turn left onto US 82
2.4 mi·3 min·US 82
26
Keep slight left at fork onto US 82
0.4 mi·29 sec·US 82
27
Keep slight left at fork onto US 82
13 mi·15 min·US 82
28
Turn right onto MS 182
9.2 mi·13 min·MS 182
29
Turn right onto South Main Street
0.9 mi·2 min·South Main Street
30
Turn right onto MS 814
10 ft·0 sec·South Broadway Street
31
Arrive at destination
MS 814
Trip Plan
To ensure a smooth arrival in Greenville, aim to depart early in the morning to maximize daylight hours during your 6-hour trek. Since you only have one recommended stop planned, use that break strategically to refuel and stretch your legs, keeping your $44 fuel budget in mind as you monitor your gauge. The highway-heavy nature of this trip means you should stay alert for shifting traffic patterns when transitioning between I-59 and US 49. Because the drive is manageable in one day, you have the flexibility to adjust your departure time based on personal preference rather than strict logistical constraints. Always check your tire pressure before heading out, as the sustained highway speeds will put steady demand on your vehicle throughout the 290.6-mile trip.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 145.3 miles from Bay Saint Louis, MS, or about 3h 4m into the drive.
The longest continuous stretch on this route runs about 89.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 64 miles or 1h 27m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 145.3 miles or 3h 4m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 58m
Traffic, exits, and arrival timing usually matter more near Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Bay Saint Louis, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Bay Saint Louis, MS
This is one driving day of about 290.6 miles and 6h 6m.
Your first comfortable stop window is around 64 miles from Bay Saint Louis, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 89.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 18
5 decision points cluster between mile 44.2 and 172.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
44.2 mi into trip|~1h 6m in|I 59
Merge onto I 59
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
7
84.6 mi into trip|~1h 49m in
Take the exit toward US 49 North, MS 42 West: Jackson
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward US 49 North, MS 42 West: Jackson
5
166.9 mi into trip|~3h 30m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
6
170.2 mi into trip|~3h 35m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
5
172.9 mi into trip|~3h 38m in|US 49
Take the exit onto US 49 toward I 220 North, I 49 North: North Jackson, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 220 North, I 49 North: North Jackson,...
Fuel & Cost
Regular Gas
$43.89 one way
$87.77 round trip
$3.84/gal25.4 MPG avg102 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$48.18
$96.36
premium
$4.56
$52.16
$104.32
diesel
$5.61
$64.16
$128.32
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$44
Meals
$25–$50
Total
$69–$94
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 101.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $31 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
87.2
1
$30.51
$13.95
Efficient EV
72.7
0
$25.43
$11.62
EV Truck/SUV
116.2
1
$40.68
$18.60
Gas CO2
102 kg
EV CO2
34 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jun 2, 2022
Origin
Bay Saint Louis, MS
Night
in Bay Saint Louis on Saturday
Local time
11:43 PM
CDT
Current temp
88°F
Unavailable
Live forecast
Destination
Greenville, MS
Night
in Greenville on Saturday
Local time
11:43 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
11 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 6m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~9 min detour
Free
near mile 180.3
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a high-speed experience, as 85% of this route consists of highway driving. You will navigate a mix of thoroughfares, primarily relying on I-59, US 49, and US 49W to make your way north. Be prepared for a sustained pace, particularly during the longest uninterrupted stretch, which clocks in at 89.3 miles on US 49. The road maintains a consistent, efficient personality throughout the journey, prioritizing steady progress over winding backroads. While the drive is largely functional, the transition between these major arteries keeps the experience moving quickly as you cross the heart of the state.
85% highway — fuel and pacing are the main things to plan.
31 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 89.3 mi on US 49.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 44.2 miles in near I 59.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 290.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 44.2 miles (I 59): Merge point - match speed before joining. Lane positioning matters here; at 84.6 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 166.9 miles (US 49): Highway fork - watch signs carefully.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Bay Saint Louis, MS and Greenville, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Greenville is a city in Washington County, Mississippi, United States. The population was 30,000 in 2020, making it the ninth largest city in the state. It is the county seat of Washington County.
Doable as a same-day drive at 6h 6m. Total distance: 290.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 6m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 89.3 miles on US 49. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Greenville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 44.2 miles (I 59): Merge point - match speed before joining. Lane positioning matters here; at 84.6 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 166.9 miles (US 49): Highway fork - watch signs carefully.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.1 hours each way, a round trip means 12.2 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Greenville, MS before the return drive.
