If you are planning to travel between Greenwood and Greenville, expect a journey covering 205.1 miles that typically takes 4 hours and 27 minutes. This route is designed as a single-day trip, making it highly efficient for those looking to reach their destination without an overnight stay. You will primarily utilize US 278, the Pontotoc Parkway West, and I-22 to navigate through the Southeast. Budgeting around $31 for fuel should cover your needs for the duration of the drive. Because this trip remains entirely within Mississippi, you can anticipate a consistent regional feel throughout your transit.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
102.5 miles from Greenwood, MS
A natural place for your longest stop of the day
, about 2h 15m into the drive
.
Main Roads
Road
Distance
Duration
US 278
126.7 mi
2h 41m
Pontotoc Parkway West
29.8 mi
34m
I 22
16.8 mi
18m
MS 9
9.8 mi
11m
MS 182
8.7 mi
12m
MS 178
4.8 mi
6m
Dorsey Evergreen Road
2.9 mi
11m
North Broad Street
1.4 mi
2m
Longest stretch:
US 278
— 126.7 mi, about 2h 41m
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenwood, MS and Greenville, MS.
1
Start on Greenwood Hopewell Road
145 ft·7 sec·Greenwood Hopewell Road
2
Turn left onto Dorsey Evergreen Road
428 ft·18 sec·Dorsey Evergreen Road
3
Keep slight right at fork onto Dorsey Evergreen Road
2.4 mi·9 min·Dorsey Evergreen Road
4
At end of road, turn right onto Bankhead Road Southwest
0.1 mi·26 sec·Bankhead Road Southwest
5
Turn left onto Dorsey Evergreen Road
0.4 mi·1 min·Dorsey Evergreen Road
6
Turn left onto MS 178
4.8 mi·6 min·MS 178
7
Turn right onto MS 371
0.9 mi·1 min·MS 371
8
Take the ramp
0.3 mi·35 sec
9
Merge onto I 22; US 78
17 mi·18 min·I 22; US 78
10
Take the exit
0.3 mi·43 sec
Exit 76--Toward MS 9 South: Sherman, Pontotoc
11
Turn slight left
131 ft·10 sec
12
Turn left onto MS 9
9.8 mi·11 min·MS 9
Use the straight lane.
13
Take the exit
0.3 mi·50 sec
Toward US 278 West, MS 6 West: Oxford, University of MississippiUse the right lane.
14
Merge onto US 278; MS 6
5.4 mi·6 min·Pontotoc Parkway West
15
Keep slight right at fork onto US 278; MS 6
24 mi·28 min·Pontotoc Parkway West
16
Continue on MS 6; US 278
0.5 mi·35 sec·MS 6; US 278
17
Continue on US 278; MS 6
62 mi·1 hr 22 min·US 278; MS 6
18
Take the exit onto US 278
65 mi·1 hr 19 min·US 278
19
Turn right onto Griffin Road
145 ft·7 sec·Griffin Road
20
Turn left onto Old Hwy 61
0.8 mi·1 min·Old Hwy 61
21
Turn straight onto North Broad Street
1.4 mi·2 min·North Broad Street
22
Turn right onto MS 182
8.7 mi·12 min·MS 182
23
Turn right onto South Main Street
0.9 mi·2 min·South Main Street
24
Turn right onto MS 814
10 ft·0 sec·South Broadway Street
25
Arrive at destination
MS 814
Trip Plan
Since this is a 205.1-mile trek, planning for at least one dedicated stop will help keep your energy levels consistent behind the wheel. Given the reliance on major highways like I-22, try to avoid peak commuting hours to ensure you maintain your estimated 4-hour and 27-minute arrival time. Keep a close eye on your fuel gauge during that long 126.7-mile stretch on US 278, as service station intervals may be less frequent than on the interstate portions. Having a $31 fuel budget set aside is a smart way to streamline your planning before you pull out of Greenwood.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 102.5 miles from Greenwood, MS, or about 2h 15m into the drive.
The longest continuous stretch on this route runs about 126.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 45 miles or 1h 2m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 102.5 miles or 2h 15m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 37m
Traffic, exits, and arrival timing usually matter more near Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenwood, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenwood, MS
This is one driving day of about 205.1 miles and 4h 27m.
Your first comfortable stop window is around 45 miles from Greenwood, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 278 for about 126.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 17
5 decision points cluster between mile 0 and 36 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
0 mi into trip|~0m in|Dorsey Evergreen Road
Turn left onto Dorsey Evergreen Road
Navigation decision point
4
0.1 mi into trip|~0m in|Dorsey Evergreen Road
Keep slight right at fork onto Dorsey Evergreen Road
Highway fork - watch signs carefully
6
25.9 mi into trip|~38m in
Take the exit toward MS 9 South: Sherman, Pontotoc
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 76--
Toward MS 9 South: Sherman, Pontotoc
5
26.2 mi into trip|~39m in|MS 9
Turn left onto MS 9
Lane positioning matters here
Use the straight lane.
7
36 mi into trip|~51m in
Take the exit toward US 278 West, MS 6 West: Oxford, University of Mississippi
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the right lane.
Toward US 278 West, MS 6 West: Oxford, Universi...
Fuel & Cost
Regular Gas
$30.97 one way
$61.95 round trip
$3.84/gal25.4 MPG avg72 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$34.00
$68.01
premium
$4.56
$36.81
$73.63
diesel
$5.61
$45.28
$90.57
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$31
Meals
$25–$50
Total
$56–$81
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 71.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $22 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
61.5
0
$21.54
$9.84
Efficient EV
51.3
0
$17.95
$8.20
EV Truck/SUV
82
1
$28.71
$13.13
Gas CO2
72 kg
EV CO2
24 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Greenwood, MS
Morning
in Greenwood on Sunday
Local time
9:57 AM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Greenville, MS
Morning
in Greenville on Sunday
Local time
9:57 AM
CDT
Current temp
77°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
4h 27m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Natchez Trace National Scenic Trail
National Scenic Trail
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
4 mi from route
~10 min detour
Free
near mile 21.2
Park Closure: Partial Closure of Rocky Springs Trail
Park Closure: Temporary Blackland Prairie Trail Closure to Equestrians
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
5 mi from route
~11 min detour
Free
near mile 21.2
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
19 mi from route
~47 min detour
Free
near mile 127.3
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This highway-focused drive is built for speed and efficiency, with 97% of the journey spent on major thoroughfares. You should prepare for a significant amount of time on the open road, as the longest uninterrupted stretch spans 126.7 miles along US 278. The character of the drive is straightforward and consistent, lacking the technical twists of local backroads in favor of a steady interstate pace. Expect a high-speed experience that prioritizes reaching your destination quickly rather than meandering through smaller corridors.
97% highway — fuel and pacing are the main things to plan.
25 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 126.7 mi on US 278.
How Hard Is This Drive?
6/10
This is a straightforward highway drive that stays mostly on US 278 and Pontotoc Parkway West. You will hit about 17 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near Dorsey Evergreen Road.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 205.1 miles you will encounter 17 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (Dorsey Evergreen Road): Navigation decision point; at 0.1 miles (Dorsey Evergreen Road): Highway fork - watch signs carefully; at 25.9 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Greenwood, MS and Greenville, MS, road signs point toward Pontotoc and University Of Mississippi.
Greenville is a city in Washington County, Mississippi, United States. The population was 30,000 in 2020, making it the ninth largest city in the state. It is the county seat of Washington County.
Doable as a same-day drive at 4h 27m. Total distance: 205.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 27m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (97%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 126.7 miles on US 278. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Greenville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (Dorsey Evergreen Road): Navigation decision point; at 0.1 miles (Dorsey Evergreen Road): Highway fork - watch signs carefully; at 25.9 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Yes — Natchez Trace National Scenic Trail, Tupelo National Battlefield and Emmett Till and Mamie Till-Mobley National Monument. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.5 hours each way, an in-and-out day trip would put you behind the wheel for 8.9 hours — manageable with a long break at Greenville, MS, but most travelers stay overnight.
