Traveling from Laurel to Biloxi is a straightforward 108-mile journey that typically takes about 2 hours and 9 minutes. Because this is a highly efficient, highway-focused drive, it works perfectly as a quick day trip, allowing you to reach the coast without needing an overnight stay. Expect to spend roughly $17 on fuel for the round trip. You will spend the vast majority of your time on major thoroughfares, making this a practical choice for those prioritizing speed and reliability over back-road exploration. Both cities are located within the Southeast region of Mississippi, ensuring a consistent climate and environment throughout your transit.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
54 miles from Laurel, MS
A natural place for your longest stop of the day
, about 1h 2m into the drive
.
Main Roads
Road
Distance
Duration
US 49
41.9 mi
49m
I 59
35.6 mi
38m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
Division Street
0.6 mi
1m
Main Street
0.5 mi
1m
Leontyne Price Boulevard
0.5 mi
1m
Longest stretch:
US 49
— 41.9 mi, about 49m
Turn-by-Turn Driving Directions
Step-by-step road directions between Laurel, MS and Biloxi, MS.
1
Start on Yates Avenue
157 ft·8 sec·Yates Avenue
2
Turn right onto North 5th Avenue
264 ft·14 sec·North 5th Avenue
3
Turn left onto Sawmill Road
218 ft·4 sec·Sawmill Road
4
Keep slight left at fork onto Sawmill Road
473 ft·10 sec·Sawmill Road
5
Enter roundabout onto 6th Avenue
164 ft·3 sec·6th Avenue
6
Continue on 6th Avenue
0.1 mi·13 sec·6th Avenue
7
Continue on Leontyne Price Boulevard
0.5 mi·1 min·Leontyne Price Boulevard
8
Take the ramp
0.2 mi·20 sec
9
Merge onto I 59; US 84; MS 15
36 mi·38 min·I 59; US 84; MS 15
Use the straight / slight right lanes.
10
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
11
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
12
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
13
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
14
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
15
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
16
Continue on I 110
3.2 mi·4 min·I 110
17
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
18
Turn left onto Division Street
0.6 mi·1 min·Division Street
19
Turn right onto Main Street
0.5 mi·1 min·Main Street
20
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
21
Arrive at destination
Howard Avenue
Trip Plan
Since this is a relatively short trip, you have plenty of flexibility in your departure time, though planning for a two-hour window ensures a stress-free arrival. Because there are no mandatory stops scheduled on this 108-mile route, you have the freedom to drive straight through or break up the journey as you see fit. Keep an eye on your fuel gauge before leaving Laurel, as the $17 estimated cost provides a good baseline for your budget. A helpful tip for this route is to monitor traffic patterns specifically on US 49, as its 41.9-mile stretch is the primary artery where you will spend the bulk of your time.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 54 miles from Laurel, MS, or about 1h 2m into the drive.
The longest continuous stretch on this route runs about 41.9 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 24 miles or 27m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 54 miles or 1h 2m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 43m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Laurel, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Laurel, MS
This is one driving day of about 108 miles and 2h 9m.
Your first comfortable stop window is around 24 miles from Laurel, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on US 49 for about 41.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 0.2 and 40.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
0.2 mi into trip|~0m in|6th Avenue
Enter roundabout onto 6th Avenue
Roundabout - know your exit number before entering
7
36.6 mi into trip|~41m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
39.8 mi into trip|~45m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
40.1 mi into trip|~46m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
6
40.2 mi into trip|~46m in|US 49
Turn right onto US 49
Lane positioning matters here
Use the straight lane.
Fuel & Cost
Regular Gas
$16.31 one way
$32.62 round trip
$3.84/gal25.4 MPG avg38 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$17.91
$35.81
premium
$4.56
$19.38
$38.77
diesel
$5.61
$23.85
$47.69
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$16
Meals
$25–$50
Total
$41–$66
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 37.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $11 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
32.4
0
$11.34
$5.18
Efficient EV
27
0
$9.45
$4.32
EV Truck/SUV
43.2
0
$15.12
$6.91
Gas CO2
38 kg
EV CO2
13 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Laurel, MS
Morning
in Laurel on Tuesday
Local time
7:21 AM
CDT
Current temp
84°F
Unavailable
Live forecast
Destination
Biloxi, MS
Morning
in Biloxi on Tuesday
Local time
7:21 AM
CDT
Current temp
78°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
6 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 9m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
With 97% of this route consisting of highway driving, you can expect a consistent and fast-paced experience behind the wheel. The journey utilizes a combination of I-59, US 49, and the Biloxi-D'Iberville Scenic Expressway to keep you moving efficiently toward the coast. You will encounter your longest uninterrupted stretch on US 49, which spans 41.9 miles of the trip. The road personality remains focused on high-speed transit rather than technical turns or winding scenery, making it a functional and predictable drive. As you approach the final leg, the transition onto the expressway signals your arrival in the Biloxi area.
97% highway — fuel and pacing are the main things to plan.
21 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 41.9 mi on US 49.
How Hard Is This Drive?
7/10
This is a straightforward highway drive that stays mostly on US 49 and I 59. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.2 miles in near 6th Avenue.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 15 significant decision points across 108 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.2 miles (6th Avenue): Roundabout - know your exit number before entering; at 36.6 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 39.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Laurel, MS and Biloxi, MS, road signs point toward Mobile, Gulfport, Mississippi Gulf Coast, Multi Purpose Center and Hattiesburg.
Laurel is a small city in the inland area of the Gulf Coast region of Mississippi. It's best known in American culture as the home base of husband-and-wife home renovation team Ben and Erin Napier, stars of the HGTV series Home Town.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Doable as a same-day drive at 2h 9m. Total distance: 108 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
2h 9m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (97%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 41.9 miles on US 49. The full list of main roads is in the Roads section above.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Biloxi, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 0.2 miles (6th Avenue): Roundabout - know your exit number before entering; at 36.6 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 39.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes. A round trip is manageable in a single day if you plan a break at Biloxi, MS before heading back.
