Moorhead, MS to Biloxi, MS is 258.9 miles and takes about 5h 20m via US 49, with a fuel budget near $38 and enough daylight to finish in a day. This trip stays within Mississippi, moving from the Southeast region down to the coast. Given the relatively short duration and mostly highway profile, this route is a straightforward drive for a single day. Expect a practical, no-frills travel experience, getting you from point A to point B efficiently.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
129.4 miles from Moorhead, MS
A natural place for your longest stop of the day
, about 2h 42m into the drive
.
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
US 49
53.4 mi
1h 4m
North Martin Luther King Drive
39.7 mi
47m
Jerry Clower Boulevard
38.8 mi
47m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
Olive Street
7.4 mi
13m
US 98
3.2 mi
4m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Traffic on I-20
Hour-of-day weekday pattern from 28 FHWA count stations on your route.
Peak
7 AM
~3,273 veh/hr typical
· worst 5,355
Quietest
2 AM
~278 veh/hr
Peak-to-quiet ratio
11.8×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 103 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Moorhead, MS and Biloxi, MS.
1
Start on MS 3
7.4 mi·13 min·Olive Street
2
At end of road, turn left onto US 49W
40 mi·47 min·North Martin Luther King Drive
3
Keep slight right at fork onto US 49W
0.5 mi·53 sec·US 49W
Toward US 49 South: Jackson
4
Merge onto US 49
39 mi·47 min·Jerry Clower Boulevard
5
Take the exit onto US 49
4.9 mi·5 min·US 49
6
Keep slight left at fork onto US 49
3.8 mi·5 min·US 49
7
Merge onto I 20; I 55; US 49
1.1 mi·1 min·I 20; I 55; US 49
8
Keep slight right at fork onto I 20; US 49
347 ft·4 sec·I 20; US 49
Toward Meridian, Hattiesburg
9
Take the exit onto US 49
0.6 mi·42 sec·US 49
Toward Hattiesburg
10
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
11
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
12
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
13
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
14
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
15
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
16
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
17
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
18
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
19
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
20
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
21
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
22
Continue on I 110
3.2 mi·4 min·I 110
23
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
24
Turn left onto Division Street
0.6 mi·1 min·Division Street
25
Turn right onto Main Street
0.5 mi·1 min·Main Street
26
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
27
Arrive at destination
Howard Avenue
Trip Plan
This is a drive that can easily be completed in one day, so you have flexibility with your departure time. Leaving in the morning will give you plenty of daylight to reach Biloxi comfortably. With a drive time of around 5 hours and 20 minutes, you'll likely want to plan for one stop. Keep an eye on your fuel gauge, as the estimated cost is $38, and it’s always wise to top off before heading into longer stretches, especially the 80.3-mile section on Highway 49 South.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 129.4 miles from Moorhead, MS, or about 2h 42m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 57 miles or 1h 12m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 129.4 miles or 2h 42m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 22m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Moorhead, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Moorhead, MS
This is one driving day of about 258.9 miles and 5h 20m.
Your first comfortable stop window is around 57 miles from Moorhead, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 20
5 decision points cluster between mile 96.3 and 191 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
96.3 mi into trip|~2h 1m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Meridian, Hattiesburg
7
179.4 mi into trip|~3h 43m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
187.5 mi into trip|~3h 52m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
190.7 mi into trip|~3h 56m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
191 mi into trip|~3h 57m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Fuel & Cost
Regular Gas
$39.84 one way
$79.69 round trip
$3.91/gal25.4 MPG avg91 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.37
$44.56
$89.13
premium
$4.76
$48.53
$97.06
diesel
$5.89
$60.01
$120.01
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$40
Meals
$25–$50
Total
$65–$90
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 90.6 kg one way.
Driving Electric?
About $27 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
77.7
0
$27.18
$12.43
Efficient EV
64.7
0
$22.65
$10.36
EV Truck/SUV
103.6
1
$36.25
$16.57
Gas CO2
91 kg
EV CO2
30 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 17, 2026
Origin
Moorhead, MS
Morning
in Moorhead on Sunday
Local time
6:52 AM
CDT
Current temp
70°F
Sunny
NNE 15 to 20 mph0% chanceLive forecast
Red Flag Warning
Red Flag Warning issued October 17 at 5:35AM CDT until October 17 at 7:00PM CDT by NWS Jackson MS
Wind Advisory
Wind Advisory issued October 17 at 3:29AM CDT until October 17 at 3:00PM CDT by NWS New Orleans LA
Destination
Biloxi, MS
Morning
in Biloxi on Sunday
Local time
6:52 AM
CDT
Current temp
72°F
Sunny
N 15 to 20 mph0% chanceLive forecast
Red Flag Warning
Red Flag Warning issued October 17 at 5:35AM CDT until October 17 at 7:00PM CDT by NWS Jackson MS
Wind Advisory
Wind Advisory issued October 17 at 3:29AM CDT until October 17 at 3:00PM CDT by NWS New Orleans LA
83°F
Sumrall, MS
129 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 20m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
You'll spend about 63% of this trip on highways. The longest continuous stretch on highways is 80.3 miles, mainly on US 49 South. As you transition from highway to surface roads, you'll notice a change in speed and traffic patterns. Expect a mix of cruising and navigating through more local traffic as you get closer to your destination.
63% highway — fuel and pacing are the main things to plan.
27 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80.3 mi on Highway 49 South.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Highway 49 South and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 96.3 miles in near I 20; US 49.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 258.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 96.3 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 179.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 187.5 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
387 ft20 ft
Total Climb
342 ft
Total Descent
439 ft
Highest Point
387 ft
~130.1 mi in
Elevation Range
367 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Moorhead, MS and Biloxi, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Mobile - among others.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Top landmarks
•Jefferson Davis Presidential Library and Museum — presidential library and museum for Confederate States President Jefferson Davis...
•Beauvoir — post-war home of the former President of the Confederate States of America, Jeff...
•Biloxi Light — lighthouse in Mississippi, United States
Doable as a same-day drive at 5h 20m. Total distance: 258.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 20m drive, comfortable solo distance.
Frequently Asked Questions
The longest stretch is about 80.3 miles on Highway 49 South. The full list of main roads is in the Roads section above.
Yes — we found about 9 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Biloxi, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 9 rest areas along the route for bathroom stops.
The main spots that need attention: at 96.3 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 179.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 187.5 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.3 hours each way, a round trip means 10.7 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Biloxi, MS before the return drive.
