Greenwood, MS to Biloxi, MS is 261.1 miles and takes about 5 hours 27 minutes via Highway 49 South and I-55, with a fuel budget near $38 and enough daylight to finish in a day. This trip stays within Mississippi, a journey through the heart of the Southeast. Expect a mostly highway experience, making it a straightforward drive from the Delta region down to the Gulf Coast. With only one recommended stop and a short duration, this route is ideal for a single-day trip, allowing ample time for departure and arrival.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
130.6 miles from Greenwood, MS
A natural place for your longest stop of the day
, about 2h 48m into the drive
.
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
I 55
48.8 mi
54m
US 49
44.1 mi
53m
US 49E
23.7 mi
35m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
MS 17
12.7 mi
18m
MS 12
11.2 mi
16m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Traffic on I-55
Hour-of-day weekday pattern from 41 FHWA count stations on your route.
Peak
4 PM
~3,953 veh/hr typical
Quietest
2 AM
~191 veh/hr
Peak-to-quiet ratio
20.7×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 51 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenwood, MS and Biloxi, MS.
1
Start on Main Street
1.1 mi·1 min·Main Street
2
Continue on US 49E
24 mi·35 min·US 49E
3
Continue on MS 12
11 mi·16 min·MS 12
4
Turn slight right onto MS 12; MS 17
489 ft·8 sec·MS 12; MS 17
5
Turn right onto MS 17
0.4 mi·42 sec·Yazoo Street
Use the left / straight lanes.
6
Continue on MS 17
13 mi·18 min·MS 17
7
Take the ramp
0.3 mi·40 sec
8
Merge onto I 55
49 mi·54 min·I 55
9
Take the exit
0.9 mi·1 min
Toward I 20 East, US 49 South: Meridian, Hattiesburg
10
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
11
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
12
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
13
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
14
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
15
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
16
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
17
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
18
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
19
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
20
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
21
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
22
Continue on I 110
3.2 mi·4 min·I 110
23
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
24
Turn left onto Division Street
0.6 mi·1 min·Division Street
25
Turn right onto Main Street
0.5 mi·1 min·Main Street
26
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
27
Arrive at destination
Howard Avenue
Trip Plan
Given the 5-hour 27-minute drive time, departing in the morning is recommended to maximize daylight. The route is designed for a single day, so you can be flexible with your departure time. Plan for one stop to break up the drive, perhaps around the halfway point. Keep an eye on your fuel gauge, especially during the longest stretch of 80.3 miles on Highway 49 South, as services can be spread out in some areas. The estimated fuel cost is around $38, so be prepared for that expense.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 130.6 miles from Greenwood, MS, or about 2h 48m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 57 miles or 1h 22m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 130.6 miles or 2h 48m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 29m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenwood, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenwood, MS
This is one driving day of about 261.1 miles and 5h 27m.
Your first comfortable stop window is around 57 miles from Greenwood, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 16
5 decision points cluster between mile 99.1 and 193.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
99.1 mi into trip|~2h 9m in|US 49
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Richland, Hattiesburg
7
181.7 mi into trip|~3h 50m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
189.8 mi into trip|~3h 59m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
193 mi into trip|~4h 3m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
193.3 mi into trip|~4h 4m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Fuel & Cost
Regular Gas
$36.25 one way
$72.49 round trip
$3.53/gal25.4 MPG avg91 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$3.95
$40.55
$81.11
premium
$4.29
$44.09
$88.18
diesel
$4.80
$49.30
$98.60
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$36
Meals
$25–$50
Total
$61–$86
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 91.4 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $27 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
78.3
0
$27.42
$12.53
Efficient EV
65.3
0
$22.85
$10.44
EV Truck/SUV
104.4
1
$36.55
$16.71
Gas CO2
91 kg
EV CO2
31 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 18, 2026
Origin
Greenwood, MS
Late night
in Greenwood on Sunday
Local time
3:16 AM
CDT
Current temp
74°F
Mostly Clear
0 mph1% chanceLive forecast
Heat Advisory
Heat Advisory issued July 18 at 1:20AM CDT until July 18 at 6:00PM CDT by NWS New Orleans LA
Heat Advisory
Heat Advisory issued July 17 at 11:57PM CDT until July 20 at 7:00PM CDT by NWS Jackson MS
Destination
Biloxi, MS
Late night
in Biloxi on Sunday
Local time
3:16 AM
CDT
Current temp
79°F
Mostly Clear
NW 5 mph2% chanceLive forecast
Heat Advisory
Heat Advisory issued July 18 at 1:20AM CDT until July 18 at 6:00PM CDT by NWS New Orleans LA
Heat Advisory
Heat Advisory issued July 17 at 11:57PM CDT until July 20 at 7:00PM CDT by NWS Jackson MS
96°F
Sumrall, MS
131 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 27m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
5 mi from route
~13 min detour
Free
near mile 99.1
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This drive is predominantly highway, with 95% of the route utilizing major roads. You'll encounter an 80.3-mile stretch on Highway 49 South without significant interruption. Expect a consistent highway feel for most of the 5-hour-plus trip, with minimal transitions to surface roads until nearing your destination. The high percentage of highway driving means frequent exit ramps and the potential for merging traffic as you pass through populated areas.
95% highway — fuel and pacing are the main things to plan.
27 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80.3 mi on Highway 49 South.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on Highway 49 South and I 55. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 99.1 miles in near US 49.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 16 significant decision points across 261.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 99.1 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 181.7 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 189.8 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
357 ft20 ft
Total Climb
341 ft
Total Descent
451 ft
Highest Point
357 ft
~149.2 mi in
Elevation Range
336 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Greenwood, MS and Biloxi, MS, road signs point toward Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast, Mobile and Gulfport - among others.
Greenwood is a city in Mississippi, located at the junction of the rivers Tallahatchie and Yalobusha, from whereon after it's called the Yalobusha. It's known for its extensive cotton production and remembered as one of the centres of conflict during the Civil Rights era.
Top landmarks
•Wesley Memorial Methodist Episcopal — church building in Greenwood, United States of America
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Top landmarks
•Jefferson Davis Presidential Library and Museum — presidential library and museum for Confederate States President Jefferson Davis...
•Beauvoir — post-war home of the former President of the Confederate States of America, Jeff...
•Biloxi Light — lighthouse in Mississippi, United States
Doable as a same-day drive at 5h 27m. Total distance: 261.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 27m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (95%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 80.3 miles on Highway 49 South. The full list of main roads is in the Roads section above.
Yes — we found about 8 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Biloxi, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 8 rest areas along the route for bathroom stops.
The main spots that need attention: at 99.1 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 181.7 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 189.8 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.5 hours each way, a round trip means 10.9 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Biloxi, MS before the return drive.
