East Independence, MO to Farmington, MO is 294.5 miles and takes about 5h 43m via Dwight D. Eisenhower Highway and US 67, with a fuel budget near $47 and enough daylight to finish in a day. This trip stays within Missouri, traversing the Midwest region from start to finish. You'll find that most of this drive utilizes surface roads, offering a more grounded perspective of the landscape. It's a straightforward, single-day option if you're looking to get from point A to point B without extensive highway time.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
147.2 miles from East Independence, MO
A natural place for your longest stop of the day
, about 2h 48m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
US 67
33.6 mi
38m
Avenue of the Saints
25.1 mi
30m
Police Officer Steven Jarvis Memorial Highway
18.3 mi
19m
I 270
11.5 mi
14m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi
2m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Traffic on I-70
Hour-of-day weekday pattern from 34 FHWA count stations on your route.
Peak
3 PM
~2,930 veh/hr typical
· worst 3,487
Quietest
1 AM
~260 veh/hr
Peak-to-quiet ratio
11.3×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 105 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between East Independence, MO and Farmington, MO.
1
Start on East 9th Street South
79 ft·8 sec·East 9th Street South
2
Turn left onto Main Road
0.3 mi·1 min·Main Road
3
Turn left onto East Truman Road
0.7 mi·1 min·East Truman Road
4
Turn right onto Holke Road
0.9 mi·1 min·Holke Road
5
Turn straight onto South Jackson Drive
1.2 mi·2 min·South Jackson Drive
6
Turn left onto East R.D. Mize Road
0.2 mi·37 sec·East R.D. Mize Road
7
Turn right onto South Little Blue Parkway
1.7 mi·3 min·South Little Blue Parkway
8
Take the ramp
0.3 mi·38 sec
Exit 17Toward Little Blue Parkway, 39th Street, Mall EntranceUse the left lane.
9
Continue on I 70
53 mi·56 min·Dwight D. Eisenhower Highway
10
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
15
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
16
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
17
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight / slight left lanes.
18
Take the exit
0.3 mi·38 sec
Exit 25Toward I 270: Chicago, MemphisUse the slight right lane.
19
Keep slight right at fork
0.3 mi·31 sec
Toward I 270 South: MemphisUse the slight right lane.
20
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
21
Take the exit
0.4 mi·27 sec
Exit 1AToward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry RoadUse the straight / slight right lanes.
22
Keep slight right at fork
0.4 mi·43 sec
Toward I 55 South: Memphis
23
Merge onto I 55
1.5 mi·1 min·Rosa Parks Highway
24
Continue on I 55
1.8 mi·2 min·Officer Thomas G. Smith, Jr. Memorial Highway
25
Continue on I 55
18 mi·19 min·Police Officer Steven Jarvis Memorial Highway
Use the straight / slight right lanes.
26
Take the exit
0.2 mi·19 sec
Exit 174BToward US 67 South: Farmington, Poplar Bluff
27
Keep slight left at fork
0.1 mi·17 sec
28
Enter roundabout onto US 67
30 ft·0 sec·US 67
29
Continue on US 67
34 mi·38 min·US 67
30
Take the exit onto MO 32
1.6 mi·2 min·MO 32
Toward MO 32 East: Farmington
31
Turn right onto MO H
0.4 mi·1 min·North Washington Street
32
Turn right onto West Liberty Street
252 ft·13 sec·West Liberty Street
33
Turn left onto North Jefferson Street
139 ft·6 sec·North Jefferson Street
34
Arrive at destination
North Jefferson Street
Trip Plan
Given the 5h 43m estimated drive time, leaving in the morning is recommended to allow for flexibility and daylight. While this route is manageable in one day, breaking it up would offer a more relaxed pace. Plan for at least one stop to refuel and stretch, especially since a significant portion is on surface roads. Keep an eye on your fuel gauge, as gas station availability might be less frequent on some of the longer stretches of US 67, particularly between more populated areas.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 147.2 miles from East Independence, MO, or about 2h 48m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 65 miles or 1h 15m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 147.2 miles or 2h 48m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 41m
Traffic, exits, and arrival timing usually matter more near Farmington, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving East Independence, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from East Independence, MO
This is one driving day of about 294.5 miles and 5h 43m.
Your first comfortable stop window is around 65 miles from East Independence, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 22
5 decision points cluster between mile 5 and 236 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
5 mi into trip|~10m in
Take the ramp toward Little Blue Parkway, 39th Street, Mall Entrance
Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Exit 17
Toward Little Blue Parkway, 39th Street, Mall E...
6
198.5 mi into trip|~3h 48m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
8
223.9 mi into trip|~4h 19m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
7
224.2 mi into trip|~4h 20m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
236 mi into trip|~4h 35m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Fuel & Cost
Regular Gas
$49.13 one way
$98.25 round trip
$4.24/gal25.4 MPG avg103 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$53.39
$106.79
premium
$5.26
$60.98
$121.95
diesel
$6.18
$71.64
$143.28
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$49
Meals
$25–$50
Total
$74–$99
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 103 kg one way.
Prices: EIA weekly data, 2026-10-12.
Driving Electric?
About $31 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
88.4
1
$30.92
$14.14
Efficient EV
73.6
0
$25.77
$11.78
EV Truck/SUV
117.8
1
$41.23
$18.85
Gas CO2
103 kg
EV CO2
34 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 16, 2026
Origin
East Independence, MO
Morning
in East Independence on Saturday
Local time
6:01 AM
CDT
Current temp
52°F
Cloudy
NNW 15 to 20 mph9% chanceLive forecast
Freeze Warning
Freeze Warning issued October 16 at 9:40AM CDT until October 17 at 9:00AM CDT by NWS Kansas City/Pleasant Hill MO
Destination
Farmington, MO
Morning
in Farmington on Saturday
Local time
6:01 AM
CDT
Current temp
56°F
Slight Chance Rain Showers
NW 17 mph24% chanceLive forecast
Freeze Warning
Freeze Warning issued October 16 at 9:40AM CDT until October 17 at 9:00AM CDT by NWS Kansas City/Pleasant Hill MO
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
4 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 43m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
13 mi from route
~33 min detour
$19
near mile 233.5
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
24 mi from route
~61 min detour
Free
near mile 274.2
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is predominantly surface roads, with only 17% of the drive on highways. You'll spend the majority of your time navigating local routes after the initial highway segments. The longest stretch on a major highway, Dwight D. Eisenhower Highway, covers 135.3 miles before you transition to more varied road types. Expect frequent changes in speed limits and scenery as you move through different towns and communities.
Only 17% highway — the rest is turn-by-turn surface driving.
34 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
9/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 5 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 22 significant decision points across 294.5 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
921 ft462 ft
Total Climb
756 ft
Total Descent
670 ft
Highest Point
921 ft
~273.4 mi in
Elevation Range
459 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between East Independence, MO and Farmington, MO, road signs point toward Memphis and Poplar Bluff.
Doable as a same-day drive at 5h 43m. Total distance: 294.5 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 43m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 135.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
Yes — we found about 34 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Farmington, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 34 rest areas along the route for bathroom stops.
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Gateway Arch National Park and Ste. Geneviève National Historical Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.7 hours each way, a round trip means 11.5 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Farmington, MO before the return drive.
