Saint Joseph, MO to Farmington, MO is 361.8 miles and takes about 6h 54m via Dwight D. Eisenhower Highway and US 67, with a fuel budget near $57 and enough daylight to finish in a day. This trip stays within Missouri, connecting two points in the Midwest. You'll experience a mix of highway cruising and surface roads, making it a straightforward drive. With a recommended one-day itinerary, this route is ideal for a direct trip across the state. Plan for roughly $57 in fuel costs to cover the 361.8 miles.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
180.9 miles from Saint Joseph, MO
A natural place for your longest stop of the day
, about 3h 18m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
US 67
33.6 mi
38m
I 29
28.4 mi
30m
I 435
28 mi
30m
Avenue of the Saints
25.1 mi
30m
Police Officer Steven Jarvis Memorial Highway
18.3 mi
19m
I 270
11.5 mi
14m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Traffic on I-70
Hour-of-day weekday pattern from 46 FHWA count stations on your route.
Peak
4 PM
~3,284 veh/hr typical
· worst 3,878
Quietest
1 AM
~292 veh/hr
Peak-to-quiet ratio
11.2×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 105 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint Joseph, MO and Farmington, MO.
1
Start on Walter Welsh Avenue
417 ft·8 sec·Walter Welsh Avenue
2
Turn right onto North 12th Street
297 ft·10 sec·North 12th Street
3
Turn right onto Francis Street
0.2 mi·37 sec·Francis Street
4
Turn left onto I 29 Business
1.2 mi·2 min·North 9th Street
5
Take the ramp
0.1 mi·15 sec
6
Merge onto US 36
0.2 mi·19 sec·US 36
7
Take the exit
0.2 mi·21 sec
Toward I 229 South, US 59 South: Kansas City
8
Merge onto I 229; US 59
4.5 mi·4 min·I 229; US 59
9
Keep slight right at fork
0.3 mi·29 sec
Toward I 29 South, US 71 South: Kansas City
10
Merge onto I 29; US 71
26 mi·27 min·I 29; US 71
11
Merge onto I 29; I 435; US 71
2.2 mi·2 min·I 29; I 435; US 71
Use the straight / slight right lanes.
12
Keep slight right at fork onto I 435
28 mi·30 min·I 435
Exit 14Toward I 435 East: Saint LouisUse the straight / slight right lanes.
13
Keep slight right at fork onto US 24
0.3 mi·23 sec·US 24
Exit 63Toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
14
Keep slight left at fork
1.2 mi·1 min
Toward I 70 East: Saint LouisUse the straight / slight right lanes.
15
Keep slight left at fork
469 ft·11 sec
Toward I 70 East: Saint LouisUse the slight left / straight lanes.
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
22
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
23
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
24
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
25
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
26
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
27
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
28
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight / slight left lanes.
29
Take the exit
0.3 mi·38 sec
Exit 25Toward I 270: Chicago, MemphisUse the slight right lane.
30
Keep slight right at fork
0.3 mi·31 sec
Toward I 270 South: MemphisUse the slight right lane.
31
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
32
Take the exit
0.4 mi·27 sec
Exit 1AToward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry RoadUse the straight / slight right lanes.
33
Keep slight right at fork
0.4 mi·43 sec
Toward I 55 South: Memphis
34
Merge onto I 55
1.5 mi·1 min·Rosa Parks Highway
35
Continue on I 55
1.8 mi·2 min·Officer Thomas G. Smith, Jr. Memorial Highway
36
Continue on I 55
18 mi·19 min·Police Officer Steven Jarvis Memorial Highway
Use the straight / slight right lanes.
37
Take the exit
0.2 mi·19 sec
Exit 174BToward US 67 South: Farmington, Poplar Bluff
38
Keep slight left at fork
0.1 mi·17 sec
39
Enter roundabout onto US 67
30 ft·0 sec·US 67
40
Continue on US 67
34 mi·38 min·US 67
41
Take the exit onto MO 32
1.6 mi·2 min·MO 32
Toward MO 32 East: Farmington
42
Turn right onto MO H
0.4 mi·1 min·North Washington Street
43
Turn right onto West Liberty Street
252 ft·13 sec·West Liberty Street
44
Turn left onto North Jefferson Street
139 ft·6 sec·North Jefferson Street
45
Arrive at destination
North Jefferson Street
Trip Plan
Given the 6-hour 54-minute duration, leaving Saint Joseph in the morning is advisable to make good time. You'll likely want to plan for at least one stop for fuel and a break, especially considering the longest stretch without a significant change in road type is over 135 miles. Keep an eye on your fuel gauge, particularly as you approach the estimated $57 budget for the 361.8-mile trip. The mix of highway and surface roads means you'll need to adjust your driving style accordingly, so be prepared for varying speed limits and traffic patterns.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 180.9 miles from Saint Joseph, MO, or about 3h 18m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 29m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 180.9 miles or 3h 18m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 43m
Traffic, exits, and arrival timing usually matter more near Farmington, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Saint Joseph, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Saint Joseph, MO
This is one driving day of about 361.8 miles and 6h 54m.
Your first comfortable stop window is around 80 miles from Saint Joseph, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 30
5 decision points cluster between mile 35.2 and 303.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
35.2 mi into trip|~39m in|I 435
Keep slight right at fork onto I 435 toward I 435 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Exit 14
Toward I 435 East: Saint Louis
7
63.2 mi into trip|~1h 10m in|US 24
Keep slight right at fork onto US 24 toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 63
Toward I 70, US 24 West, US 40: Saint Louis, Ka...
7
63.5 mi into trip|~1h 11m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Toward I 70 East: Saint Louis
8
291.2 mi into trip|~5h 29m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
8
303.3 mi into trip|~5h 45m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Fuel & Cost
Regular Gas
$60.35 one way
$120.70 round trip
$4.24/gal25.4 MPG avg127 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$65.59
$131.19
premium
$5.26
$74.91
$149.82
diesel
$6.18
$88.01
$176.03
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$60
Meals
$25–$50
Total
$85–$110
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 126.6 kg one way.
Prices: EIA weekly data, 2026-10-12.
Driving Electric?
About $38 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
108.5
1
$37.99
$17.37
Efficient EV
90.5
1
$31.66
$14.47
EV Truck/SUV
144.7
1
$50.65
$23.16
Gas CO2
127 kg
EV CO2
42 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 17, 2026
Origin
Saint Joseph, MO
Morning
in Saint Joseph on Saturday
Local time
11:33 AM
CDT
Current temp
33°F
Areas Of Frost
0 mph0% chanceLive forecast
Freeze Warning
Freeze Warning issued October 16 at 9:40AM CDT until October 17 at 9:00AM CDT by NWS Kansas City/Pleasant Hill MO
Destination
Farmington, MO
Morning
in Farmington on Saturday
Local time
11:33 AM
CDT
Current temp
36°F
Partly Cloudy
N 8 mph0% chanceLive forecast
Freeze Warning
Freeze Warning issued October 16 at 9:40AM CDT until October 17 at 9:00AM CDT by NWS Kansas City/Pleasant Hill MO
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 54m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
13 mi from route
~34 min detour
$19
near mile 299.4
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
25 mi from route
~62 min detour
Free
near mile 361.8
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route offers a mixed driving experience, with about 30% of the drive on highways. You'll encounter a longest stretch of 135.3 miles on the Dwight D. Eisenhower Highway before transitioning to surface roads. Expect to see a variety of scenery as you move from more developed areas to more rural cruising. The transition between highway and surface roads will likely involve a change in the pace of traffic and the density of exits.
30% highway, the rest on surface roads — varied driving throughout.
45 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
10/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 35.2 miles in near I 435.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 30 significant decision points across 361.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 35.2 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 63.2 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 63.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Elevation Profile
Mostly flat terrain
982 ft462 ft
Total Climb
800 ft
Total Descent
779 ft
Highest Point
982 ft
~25.8 mi in
Elevation Range
520 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Saint Joseph, MO and Farmington, MO, road signs point toward Kansas City, Sports Complex, Memphis and Poplar Bluff.
Doable as a same-day drive at 6h 54m. Total distance: 361.8 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 54m drive, plan rest stops for pacing.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 135.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
Yes — we found about 44 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Farmington, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 44 rest areas along the route for bathroom stops.
The main spots that need attention: at 35.2 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 63.2 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 63.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Yes — Gateway Arch National Park and Ste. Geneviève National Historical Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.9 hours each way, a round trip means 13.8 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Farmington, MO before the return drive.
