Embarking from East Independence, MO, this journey to Clarkton, MO, covers 416.4 miles and is estimated to take around 8 hours and 4 minutes of driving time. Given the duration and the 'turn-heavy local drive' profile, splitting this trip over two days is highly recommended to make it more enjoyable. The estimated fuel cost for this drive is approximately $63. You'll be navigating primarily local roads, with no highway driving, suggesting a more intimate experience with the Missouri landscape. This route is a good option if you're looking for a less hurried, more ground-level exploration within the Midwest.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
208.2 miles from East Independence, MO
A natural place for your longest stop of the day
, about 4h into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
Police Officer Steven Jarvis Memorial Highway
126.7 mi
2h 15m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Avenue of the Saints
25.1 mi
30m
US 60
22.6 mi
26m
US 60 Business
21.1 mi
31m
I 270
11.5 mi
14m
US 62
4.4 mi
6m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Turn-by-Turn Driving Directions
Step-by-step road directions between East Independence, MO and Clarkton, MO.
1
Start on East 9th Street South
79 ft·8 sec·East 9th Street South
2
Turn left onto Main Road
0.3 mi·1 min·Main Road
3
Turn left onto East Truman Road
0.7 mi·1 min·East Truman Road
4
Turn right onto Holke Road
0.9 mi·1 min·Holke Road
5
Turn straight onto South Jackson Drive
1.2 mi·2 min·South Jackson Drive
6
Turn left onto East R.D. Mize Road
0.2 mi·37 sec·East R.D. Mize Road
7
Turn right onto South Little Blue Parkway
1.7 mi·3 min·South Little Blue Parkway
8
Take the ramp
0.3 mi·38 sec
Exit 17Toward Little Blue Parkway, 39th Street, Mall EntranceUse the left lane.
9
Continue on I 70
53 mi·56 min·Dwight D. Eisenhower Highway
10
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
15
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
16
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
17
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight / slight left lanes.
18
Take the exit
0.3 mi·38 sec
Exit 25Toward I 270: Chicago, MemphisUse the slight right lane.
19
Keep slight right at fork
0.3 mi·31 sec
Toward I 270 South: MemphisUse the slight right lane.
20
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
21
Take the exit
0.4 mi·27 sec
Exit 1AToward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry RoadUse the straight / slight right lanes.
22
Keep slight right at fork
0.4 mi·43 sec
Toward I 55 South: Memphis
23
Merge onto I 55
1.5 mi·1 min·Rosa Parks Highway
24
Continue on I 55
1.8 mi·2 min·Officer Thomas G. Smith, Jr. Memorial Highway
25
Continue on I 55
127 mi·2 hr 15 min·Police Officer Steven Jarvis Memorial Highway
Use the straight / slight right lanes.
26
Take the exit
0.5 mi·1 min
Exit 66BToward US 60 West: Dexter, Poplar Bluff
27
Merge onto US 60
23 mi·26 min·US 60
28
Take the exit onto US 60 Business
0.3 mi·40 sec·US 60 Business
Toward MO 25, US 60 Business: Dexter, Bloomfield
29
Turn left onto US 60 Business; MO 25
21 mi·31 min·US 60 Business; MO 25
30
Continue on US 62; MO 25
4.4 mi·6 min·US 62; MO 25
31
Turn left
0.3 mi·39 sec
32
Continue on this road
0.1 mi·18 sec·this road
33
Continue on North Main Street
0.5 mi·1 min·North Main Street
34
Turn left onto East Clark Street
107 ft·4 sec·East Clark Street
35
Arrive at destination
East Clark Street
Trip Plan
To best experience this 416.4-mile drive, plan for an overnight stop, as the 8-hour duration makes it challenging for a single day. Start your first day early to maximize daylight, especially since you'll be on local roads with potentially lower speeds. With two recommended stops, you can break up the 416.4 miles into manageable segments, perhaps aiming for roughly 200 miles each day. Keep an eye on your fuel gauge, as local roads can sometimes have fewer services than major highways; the $63 fuel cost is a good estimate to budget for. A specific tip for this route: be prepared for slower speeds and potential local traffic delays as you pass through smaller towns.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 208.2 miles from East Independence, MO, or about 4h into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 92 miles or 1h 44m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 208.2 miles or 4h in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 208.2 miles or 4h
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 6h 45m
Traffic, exits, and arrival timing usually matter more near Clarkton, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving East Independence, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from East Independence, MO
Aim for roughly 208 miles and 4 hours of wheel time on this day.
Day 2
Finish the approach into Clarkton, MO
Aim for roughly 208 miles and 4 hours of wheel time on this day.
Your first comfortable stop window is around 92 miles from East Independence, MO.
This route usually feels better as a 2-day drive than as one long push.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 20
5 decision points cluster between mile 5 and 236 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
5 mi into trip|~10m in
Take the ramp toward Little Blue Parkway, 39th Street, Mall Entrance
Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Exit 17
Toward Little Blue Parkway, 39th Street, Mall E...
6
198.5 mi into trip|~3h 48m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
8
223.9 mi into trip|~4h 19m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
7
224.2 mi into trip|~4h 20m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
236 mi into trip|~4h 35m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Fuel & Cost
Regular Gas
$65.10 one way
$130.20 round trip
$3.97/gal25.4 MPG avg146 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$71.48
$142.95
premium
$4.89
$80.13
$160.26
diesel
$5.61
$91.94
$183.87
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$65
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$195–$305
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 145.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $44 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
124.9
1
$43.72
$19.99
Efficient EV
104.1
1
$36.43
$16.66
EV Truck/SUV
166.6
2
$58.30
$26.65
Gas CO2
146 kg
EV CO2
49 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
East Independence, MO
Evening
in East Independence on Saturday
Local time
8:08 PM
CDT
Current temp
56°F
Unavailable
Live forecast
Destination
Clarkton, MO
Evening
in Clarkton on Saturday
Local time
8:08 PM
CDT
Current temp
76°F
Unavailable
Live forecast
57°F
Chesterfield, MO
208 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
20 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
8h 4m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Ste. Geneviève National Historical Park
National Historical Park
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
6 mi from route
~14 min detour
Free
near mile 287.2
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
14 mi from route
~35 min detour
$19
near mile 229.7
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This drive is characterized as a 'turn-heavy local drive' with a 0% highway share, meaning you'll be spending your entire 8-hour journey on smaller roads. Expect frequent turns and a constant engagement with the local infrastructure, rather than long stretches of high-speed travel. While there's no specified longest uninterrupted stretch, the nature of local roads suggests you'll be encountering various speed limits and opportunities to pull over frequently. The drive will likely feel like a continuous exploration of Missouri's towns and countryside, rather than a quick transit.
Only 15% highway — the rest is turn-by-turn surface driving.
35 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
10/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 5 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 416.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between East Independence, MO and Clarkton, MO, road signs point toward Memphis, Poplar Bluff and Bloomfield.
Memphis
223.9 mi in|~4h 19m
Poplar Bluff
366.8 mi in|~6h 56m
Bloomfield
389.9 mi in|~7h 23m|via US 60 Business
Who Is This Route For?
Solo Traveler
8h 4m drive, plan rest stops for pacing.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 135.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
Yes — a 2-day pace is more comfortable than one long haul. A sensible stopping point is after roughly 208 miles on day one.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Clarkton, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Ste. Geneviève National Historical Park and Gateway Arch National Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 8.1 hours each way, a round trip means 16.1 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Clarkton, MO before the return drive.
