East Independence, MO to East Prairie, MO is 387.8 miles and takes about 7h 21m via Dwight D. Eisenhower Highway, with a fuel budget near $61 and enough daylight to finish in a day. This drive stays within the Midwest, traversing Missouri for its entirety. Expect a trip that largely utilizes surface roads, offering a more grounded travel experience than a pure interstate run. With just two recommended stops and a longest stretch of over 135 miles, it's a manageable one-day commitment for those looking to cover ground efficiently.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
193.9 miles from East Independence, MO
A natural place for your longest stop of the day
, about 3h 43m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
Police Officer Steven Jarvis Memorial Highway
127.1 mi
2h 16m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Avenue of the Saints
25.1 mi
30m
I 270
11.5 mi
14m
I 57
10.3 mi
11m
South Main Street
9.4 mi
12m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Traffic on I-70
Hour-of-day weekday pattern from 34 FHWA count stations on your route.
Peak
3 PM
~2,930 veh/hr typical
· worst 3,487
Quietest
1 AM
~260 veh/hr
Peak-to-quiet ratio
11.3×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 105 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between East Independence, MO and East Prairie, MO.
1
Start on East 9th Street South
79 ft·8 sec·East 9th Street South
2
Turn left onto Main Road
0.3 mi·1 min·Main Road
3
Turn left onto East Truman Road
0.7 mi·1 min·East Truman Road
4
Turn right onto Holke Road
0.9 mi·1 min·Holke Road
5
Turn straight onto South Jackson Drive
1.2 mi·2 min·South Jackson Drive
6
Turn left onto East R.D. Mize Road
0.2 mi·37 sec·East R.D. Mize Road
7
Turn right onto South Little Blue Parkway
1.7 mi·3 min·South Little Blue Parkway
8
Take the ramp
0.3 mi·38 sec
Exit 17Toward Little Blue Parkway, 39th Street, Mall EntranceUse the left lane.
9
Continue on I 70
53 mi·56 min·Dwight D. Eisenhower Highway
10
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
15
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
16
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
17
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight / slight left lanes.
18
Take the exit
0.3 mi·38 sec
Exit 25Toward I 270: Chicago, MemphisUse the slight right lane.
19
Keep slight right at fork
0.3 mi·31 sec
Toward I 270 South: MemphisUse the slight right lane.
20
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
21
Take the exit
0.4 mi·27 sec
Exit 1AToward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry RoadUse the straight / slight right lanes.
22
Keep slight right at fork
0.4 mi·43 sec
Toward I 55 South: Memphis
23
Merge onto I 55
1.5 mi·1 min·Rosa Parks Highway
24
Continue on I 55
1.8 mi·2 min·Officer Thomas G. Smith, Jr. Memorial Highway
25
Continue on I 55
127 mi·2 hr 16 min·Police Officer Steven Jarvis Memorial Highway
Use the straight / slight right lanes.
26
Take the exit
0.2 mi·30 sec
Exit 66AToward I 57 North, US 60 East: Chicago
27
Merge onto I 57; US 60
10 mi·11 min·I 57; US 60
28
Take the exit onto I 57 Business
0.2 mi·27 sec·I 57 Business
Toward I 57 Business North, MO 105: Charleston, East Prairie
29
Turn right onto MO 105
9.4 mi·12 min·South Main Street
30
Turn left onto MO 80
0.3 mi·38 sec·North Washington Street
31
Turn left onto East Main Street
86 ft·3 sec·East Main Street
32
Arrive at destination
East Main Street
Trip Plan
Given the 7h 21m estimated drive time, starting your trip in East Independence, MO, shortly after sunrise will give you ample daylight to reach East Prairie, MO, comfortably within a single day. Plan for your two stops to break up the 387.8 miles, perhaps around the halfway point or when you transition off the Dwight D. Eisenhower Highway. Keep an eye on your fuel gauge, especially during the longer stretches, as the estimated fuel cost is $61. The predominantly surface road profile means you'll want to be aware of local speed limits and potential traffic within populated areas.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 193.9 miles from East Independence, MO, or about 3h 43m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 85 miles or 1h 37m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 193.9 miles or 3h 43m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 6h 14m
Traffic, exits, and arrival timing usually matter more near East Prairie, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving East Independence, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
Day 1
Settle into the route from East Independence, MO
This is one driving day of about 387.8 miles and 7h 21m.
Your first comfortable stop window is around 85 miles from East Independence, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 20
5 decision points cluster between mile 5 and 236 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
5 mi into trip|~10m in
Take the ramp toward Little Blue Parkway, 39th Street, Mall Entrance
Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Exit 17
Toward Little Blue Parkway, 39th Street, Mall E...
6
198.5 mi into trip|~3h 48m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
8
223.9 mi into trip|~4h 19m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
7
224.2 mi into trip|~4h 20m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
236 mi into trip|~4h 35m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Fuel & Cost
Regular Gas
$64.69 one way
$129.38 round trip
$4.24/gal25.4 MPG avg136 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$70.31
$140.62
premium
$5.26
$80.29
$160.59
diesel
$6.18
$94.34
$188.68
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$65
Meals
$25–$50
Total
$90–$115
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 135.7 kg one way.
Prices: EIA weekly data, 2026-10-12.
Driving Electric?
About $41 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
116.3
1
$40.72
$18.61
Efficient EV
97
1
$33.93
$15.51
EV Truck/SUV
155.1
1
$54.29
$24.82
Gas CO2
136 kg
EV CO2
45 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 18, 2026
Origin
East Independence, MO
Late night
in East Independence on Monday
Local time
4:51 AM
CDT
Current temp
40°F
Clear
SSW 5 mph0% chanceLive forecast
Destination
East Prairie, MO
Late night
in East Prairie on Monday
Local time
4:51 AM
CDT
Current temp
36°F
Clear
ENE 2 mph0% chanceLive forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
4 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
7h 21m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Ste. Geneviève National Historical Park
National Historical Park
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
6 mi from route
~16 min detour
Free
near mile 280.8
Park Closure: Janis-Ziegler House (Green Tree Tavern) Closed
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
14 mi from route
~36 min detour
$19
near mile 227.3
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
You'll spend about 6% of this 387.8-mile trip on highways like the Dwight D. Eisenhower Highway, before transitioning to mostly surface roads. The longest continuous stretch on a highway is 135.3 miles, giving you a solid block of higher-speed travel. Once you leave the main highways, anticipate navigating through towns and more varied terrain. The profile is predominantly surface roads, meaning you'll likely encounter more intersections and varying speed limits.
Only 6% highway — the rest is turn-by-turn surface driving.
32 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
10/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 5 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 387.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
891 ft307 ft
Total Climb
405 ft
Total Descent
928 ft
Highest Point
891 ft
~166.2 mi in
Elevation Range
584 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from East Independence, MO to East Prairie, MO, road signs begin pointing toward Memphis along the way.
Doable as a same-day drive at 7h 21m. Total distance: 387.8 miles.
Family Friendly
Moderate complexity with 2 natural rest stops along the way.
Solo Traveler
7h 21m drive, plan rest stops for pacing.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 135.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
Yes — we found about 39 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at East Prairie, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. There are 39 rest areas along the route for bathroom stops.
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Ste. Geneviève National Historical Park and Gateway Arch National Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 7.4 hours each way, a round trip means 14.7 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at East Prairie, MO before the return drive.
