If you are planning a trip from Clinton to Greenville, expect a straightforward 113.5-mile journey that typically takes about 2 hours and 26 minutes to complete. This drive stays entirely within Mississippi, keeping you in the Southeast region for the duration of your travel. Because of the manageable distance, this route works perfectly as a one-day trip, meaning you do not need to worry about booking overnight accommodations unless you prefer a slower pace. Budgeting approximately $17 for fuel should cover your needs for the round trip. It is a practical, efficiency-focused drive that connects two distinct parts of the state without requiring complex navigation or multiple days of travel.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
56.8 miles from Clinton, MS
A natural place for your longest stop of the day
, about 1h 14m into the drive
.
Main Roads
Road
Distance
Duration
US 49W
46.7 mi
56m
US 49
34.1 mi
41m
US 82
15.8 mi
19m
MS 182
8.3 mi
12m
Pinehaven Road
5.4 mi
9m
Martin Luther King Junior Boulevard
1 mi
1m
Clinton Parkway
0.8 mi
1m
East Reed Road
0.7 mi
1m
Longest stretch:
US 49W
— 46.7 mi, about 56m
Turn-by-Turn Driving Directions
Step-by-step road directions between Clinton, MS and City of Greenville, MS.
1
Start on Dunton Road
0.3 mi·1 min·Dunton Road
2
Continue on East Leake Street
0.2 mi·44 sec·East Leake Street
3
Turn left onto East Street
0.1 mi·30 sec·East Street
4
Turn left onto East Main Street
366 ft·16 sec·East Main Street
5
Turn left onto Clinton Parkway
0.8 mi·1 min·Clinton Parkway
6
Continue on Pinehaven Road
5.4 mi·9 min·Pinehaven Road
7
At end of road, turn left onto US 49
34 mi·41 min·US 49
8
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
9
Turn left onto US 82
2.4 mi·3 min·US 82
10
Keep slight left at fork onto US 82
0.4 mi·29 sec·US 82
11
Keep slight left at fork onto US 82
13 mi·15 min·US 82
12
Turn right onto MS 182
8.3 mi·12 min·MS 182
13
Turn left onto MS 1
1.0 mi·1 min·Martin Luther King Junior Boulevard
14
Turn right onto East Reed Road
0.7 mi·1 min·East Reed Road
15
Turn left onto Sandy Avenue
46 ft·2 sec·Sandy Avenue
16
Arrive at destination
Sandy Avenue
Trip Plan
Since this is a relatively short drive, you have the flexibility to depart whenever suits your schedule best. Because there are no mandatory stops scheduled, consider planning your own breaks along the 113.5-mile path to stretch your legs and refresh. Keep a close eye on your fuel gauge before leaving Clinton, as the $17 estimated cost assumes a standard vehicle efficiency. Given the reliance on US 49W, US 49, and US 82, monitor local traffic reports for these specific corridors before you head out to ensure a smooth transition between highways. Taking advantage of the quick transit time allows you to maximize your afternoon upon arrival in Greenville.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 56.8 miles from Clinton, MS, or about 1h 14m into the drive.
The longest continuous stretch on this route runs about 46.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 25 miles or 35m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 56.8 miles or 1h 14m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 59m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Clinton, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Clinton, MS
This is one driving day of about 113.5 miles and 2h 26m.
Your first comfortable stop window is around 25 miles from Clinton, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on US 49W for about 46.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
2.6 mi from route
~7 min detour
$20 to $30
mile 105.4
Leland, Mississippi
Hours: 4:30–8:30 pm
+16626864401
Birthplace Of Kermit The Frog Museum
4.5
★ ★ ★ ★ ★
Near the end, short detour
2.1 mi from route
~5 min detour
mile 105.4
Leland, Mississippi
Hours: 10 am–4 pm
+16626867383
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 9
5 decision points cluster between mile 0.4 and 90.4 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0.4 mi into trip|~1m in|East Street
Turn left onto East Street
Navigation decision point
4
0.5 mi into trip|~2m in|East Main Street
Turn left onto East Main Street
Navigation decision point
5
40.9 mi into trip|~55m in|US 49W
Take the exit onto US 49W toward US 49W North, MS 3 South: Indianola, Vicksburg
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 49W North, MS 3 South: Indianola, Vic...
4
90 mi into trip|~1h 55m in|US 82
Keep slight left at fork onto US 82
Highway fork - watch signs carefully
4
90.4 mi into trip|~1h 55m in|US 82
Keep slight left at fork onto US 82
Highway fork - watch signs carefully
Fuel & Cost
Regular Gas
$17.14 one way
$34.28 round trip
$3.84/gal25.4 MPG avg40 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$18.82
$37.63
premium
$4.56
$20.37
$40.74
diesel
$5.61
$25.06
$50.12
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$17
Meals
$25–$50
Total
$42–$67
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 39.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $12 in charging
· 0 stops
· 68% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
34.1
0
$11.92
$5.45
Efficient EV
28.4
0
$9.93
$4.54
EV Truck/SUV
45.4
0
$15.89
$7.26
Gas CO2
40 kg
EV CO2
13 kg (68% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Clinton, MS
Morning
in Clinton on Sunday
Local time
10:11 AM
CDT
Current temp
54°F
Unavailable
Live forecast
Destination
City of Greenville, MS
Morning
in City of Greenville on Sunday
Local time
10:11 AM
CDT
Current temp
80°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
26 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 26m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This journey is defined by a highway-focused profile, with 93% of your time spent on major roads like US 49, US 49W, and US 82. You will find yourself settling into a steady rhythm as you navigate these routes, which offer a consistent driving experience. The longest uninterrupted stretch covers 46.7 miles on US 49W, providing plenty of time to get comfortable behind the wheel. While the road lacks the technical turns of mountainous terrain, the transition between these primary highways ensures you maintain steady progress toward your destination. Expect a reliable, predictable drive that prioritizes speed and directness over winding scenic detours.
93% highway — fuel and pacing are the main things to plan.
16 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 46.7 mi on US 49W.
How Hard Is This Drive?
5/10
This is a straightforward highway drive that stays mostly on US 49W and US 49. You will hit about 9 points where you need to pay attention to lane position or signs. The trickiest moment comes around 0.4 miles in near East Street.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 113.5 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 0.4 miles (East Street): Navigation decision point; at 0.5 miles (East Main Street): Navigation decision point; at 40.9 miles (US 49W): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Clinton, MS to City of Greenville, MS, road signs begin pointing toward Vicksburg along the way.
Vicksburg
40.9 mi in|~55m|via US 49W
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 2h 26m. Total distance: 113.5 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
2h 26m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (93%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 46.7 miles on US 49W. The full list of main roads is in the Roads section above.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: at 0.4 miles (East Street): Navigation decision point; at 0.5 miles (East Main Street): Navigation decision point; at 40.9 miles (US 49W): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Yes. A round trip is manageable in a single day if you plan a break at City of Greenville, MS before heading back.
