Spanning 238.9 miles across Mississippi, this drive from Waynesboro to Greenville takes approximately 4 hours and 54 minutes. You will primarily navigate via US 49, US 49W, and Medgar Evers Boulevard. Given the duration, this route is perfectly manageable as a single-day trip, though you should budget about $37 for fuel to cover the distance. Since both the origin and destination are located within the Southeast region, you will experience a consistent cultural and geographic transition across the state. It is a straightforward trip that avoids the need for an overnight split, making it an efficient choice for those looking to reach the Mississippi Delta from the southeastern corner of the state.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
119.4 miles from Waynesboro, MS
A natural place for your longest stop of the day
, about 2h 25m into the drive
.
Main Roads
Road
Distance
Duration
US 49
64.3 mi
1h 18m
US 49W
46.7 mi
56m
Medgar Evers Boulevard
39.5 mi
48m
Veterans Memorial Highway
27.2 mi
31m
US 84
26.3 mi
30m
US 82
15.8 mi
19m
MS 182
8.3 mi
12m
I 20
4.3 mi
5m
Longest stretch:
US 49
— 64.3 mi, about 1h 18m
Turn-by-Turn Driving Directions
Step-by-step road directions between Waynesboro, MS and City of Greenville, MS.
1
Start on MS 184
2.5 mi·4 min·Azalea Drive
2
Turn straight onto MS 184
0.2 mi·21 sec·MS 184
3
At end of road, turn left onto US 84
26 mi·30 min·US 84
Use the straight lane.
4
At end of road, turn left onto US 11
0.2 mi·17 sec·Cross Street
5
Continue on US 11
0.2 mi·26 sec·Teresa Street
6
Turn left onto North Magnolia Street
0.1 mi·11 sec·North Magnolia Street
7
Continue on Sawmill Road
0.2 mi·22 sec·Sawmill Road
8
Keep slight left at fork onto Sawmill Road
473 ft·10 sec·Sawmill Road
9
Enter roundabout onto Sawmill Road
72 ft·1 sec·Sawmill Road
10
Continue on Sawmill Road
0.5 mi·59 sec·Sawmill Road
11
Continue on West 5th Street
0.3 mi·41 sec·West 5th Street
12
Continue on US 84; MS 28
27 mi·31 min·Veterans Memorial Highway
13
Take the exit
0.2 mi·34 sec
Toward US 49 North: Jackson
14
Merge onto US 49
57 mi·1 hr 9 min·US 49
15
Take the exit onto US 49
0.2 mi·21 sec·US 49
16
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
17
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
18
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
19
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
20
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
21
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
22
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
23
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
24
Turn left onto US 82
2.4 mi·3 min·US 82
25
Keep slight left at fork onto US 82
0.4 mi·29 sec·US 82
26
Keep slight left at fork onto US 82
13 mi·15 min·US 82
27
Turn right onto MS 182
8.3 mi·12 min·MS 182
28
Turn left onto MS 1
1.0 mi·1 min·Martin Luther King Junior Boulevard
29
Turn right onto East Reed Road
0.7 mi·1 min·East Reed Road
30
Turn left onto Sandy Avenue
46 ft·2 sec·Sandy Avenue
31
Arrive at destination
Sandy Avenue
Trip Plan
To keep your drive smooth, plan for at least one dedicated stop to stretch your legs and refresh during the nearly five-hour trek. Leaving early in the day is your best bet to avoid potential traffic fatigue and ensure you arrive in Greenville with plenty of daylight to spare. Since you are looking at a $37 fuel budget, confirm your vehicle's range before departing Waynesboro to avoid unnecessary detours for gas. Take advantage of the flexibility offered by a one-day trip by keeping your itinerary light, allowing you to adjust your pace based on how you feel on the road. Specifically, keep a close watch on your speed as you transition between the various highway segments along US 49 and US 49W.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 119.4 miles from Waynesboro, MS, or about 2h 25m into the drive.
The longest continuous stretch on this route runs about 64.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 53 miles or 1h 4m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 119.4 miles or 2h 25m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 59m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Waynesboro, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Waynesboro, MS
This is one driving day of about 238.9 miles and 4h 54m.
Your first comfortable stop window is around 53 miles from Waynesboro, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 64.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 21
5 decision points cluster between mile 2.7 and 118.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
2.7 mi into trip|~4m in|US 84
At end of road, turn left onto US 84
Lane positioning matters here
Use the straight lane.
5
29.7 mi into trip|~36m in|Sawmill Road
Keep slight left at fork onto Sawmill Road
Highway fork - watch signs carefully
6
29.8 mi into trip|~36m in|Sawmill Road
Enter roundabout onto Sawmill Road
Roundabout - know your exit number before entering
6
57.8 mi into trip|~1h 9m in
Take the exit toward US 49 North: Jackson
Exit ramp - move to the correct lane early
Toward US 49 North: Jackson
6
118.6 mi into trip|~2h 24m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
Fuel & Cost
Regular Gas
$36.08 one way
$72.16 round trip
$3.84/gal25.4 MPG avg84 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$39.61
$79.21
premium
$4.56
$42.88
$85.76
diesel
$5.61
$52.75
$105.49
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$36
Meals
$25–$50
Total
$61–$86
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 83.6 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $25 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
71.7
0
$25.08
$11.47
Efficient EV
59.7
0
$20.90
$9.56
EV Truck/SUV
95.6
1
$33.45
$15.29
Gas CO2
84 kg
EV CO2
28 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Waynesboro, MS
Morning
in Waynesboro on Sunday
Local time
8:43 AM
CDT
Current temp
80°F
Unavailable
Live forecast
Destination
City of Greenville, MS
Morning
in City of Greenville on Sunday
Local time
8:43 AM
CDT
Current temp
80°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
4h 54m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a highway-focused journey, as roughly 69% of your travel time will be spent on major thoroughfares. The road maintains a steady pace, highlighted by a longest uninterrupted stretch of 64.3 miles on US 49. While the route is designed for efficient transit, the shift from southeastern landscapes toward the Delta region provides a noticeable change in the horizon. You will spend most of your time behind the wheel on high-speed roads, requiring a focused driving style rather than a technical one. The experience is practical and functional, prioritizing direct navigation over winding backroads.
69% highway — fuel and pacing are the main things to plan.
31 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 64.3 mi on US 49.
How Hard Is This Drive?
7/10
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 2.7 miles in near US 84.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 21 significant decision points across 238.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 2.7 miles (US 84): Lane positioning matters here; at 29.7 miles (Sawmill Road): Highway fork - watch signs carefully; at 29.8 miles (Sawmill Road): Roundabout - know your exit number before entering.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Waynesboro, MS and City of Greenville, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Jackson
115.2 mi in|~2h 19m|via US 49
Yazoo City
118.6 mi in|~2h 24m|via I 20; US 49
Vicksburg
166.3 mi in|~3h 23m|via US 49W
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 54m. Total distance: 238.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 54m drive, comfortable solo distance.
Frequently Asked Questions
The longest stretch is about 64.3 miles on US 49. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at City of Greenville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 2.7 miles (US 84): Lane positioning matters here; at 29.7 miles (Sawmill Road): Highway fork - watch signs carefully; at 29.8 miles (Sawmill Road): Roundabout - know your exit number before entering.
Possible but tiring. At 4.9 hours each way, an in-and-out day trip would put you behind the wheel for 9.8 hours — manageable with a long break at City of Greenville, MS, but most travelers stay overnight.
