Biloxi, MS to Natchez, MS is 225.6 miles and takes about 4h 15m via Congressman Jimmy Morrison Highway and I-10, with a fuel budget near $34 and enough daylight to finish in a day. This drive primarily stays within Mississippi, taking you from the Southeast coastal region inland. Expect a journey that's largely highway-focused, making it a straightforward trip if you're looking for efficiency. With a recommended one-day drive, you can easily complete this route without needing an overnight stop, allowing for flexibility in your schedule.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
112.8 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 2h 6m into the drive
.
Main Roads
Road
Distance
Duration
Congressman Jimmy Morrison Highway
56.4 mi
1h
I 10
51 mi
54m
West Florida Republic Parkway
47.8 mi
51m
US 84
31.4 mi
36m
US 98
30.1 mi
34m
I 110
2.4 mi
3m
Devereaux Drive
1.4 mi
2m
St Catherine Street
0.8 mi
1m
Longest stretch:
Congressman Jimmy Morrison Highway
— 56.4 mi, about 1h
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Natchez, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
2.4 mi·3 min·I 110
7
Take the exit
0.1 mi·18 sec
Exit 4ABToward I 10: Mobile
8
Keep slight right at fork
0.1 mi·27 sec
Exit 4AToward Popps Ferry Road
9
At end of road, turn left onto Big Ridge Road
0.4 mi·1 min·Big Ridge Road
10
Turn right onto D'Iberville Boulevard
0.4 mi·1 min·D'Iberville Boulevard
11
Take the ramp
0.7 mi·1 min
Use the left lane.
12
Merge onto I 10
51 mi·54 min·I 10
Use the straight / slight right lanes.
13
Keep slight right at fork onto I 12
0.2 mi·14 sec·West Florida Republic Parkway
Toward I 12, I 59: Hammond, Baton Rouge, Hattiesburg
14
Continue on I 12
48 mi·50 min·West Florida Republic Parkway
Exit 267BToward I 12: Hammond, Baton RougeUse the straight / slight right lanes.
15
Take the exit
0.4 mi·56 sec
Exit 38BToward I 55: JacksonUse the straight / slight right lanes.
16
Merge onto I 55
56 mi·1 hr·Congressman Jimmy Morrison Highway
Use the straight / slight right lanes.
17
Take the exit onto US 98
29 mi·33 min·US 98
18
At end of road, turn left onto US 98; MS 184
0.8 mi·53 sec·US 98; MS 184
19
Take the exit
0.3 mi·45 sec
20
Merge onto US 84
28 mi·32 min·US 84
21
Keep slight left at fork onto US 84
3.2 mi·3 min·US 84
22
Take the exit onto Devereaux Drive
0.2 mi·31 sec·Devereaux Drive
23
Keep slight right at fork onto Devereaux Drive
1.2 mi·1 min·Devereaux Drive
24
Continue on St Catherine Street
0.8 mi·1 min·St Catherine Street
25
Continue on St Catherine Street
294 ft·12 sec·St Catherine Street
26
Turn left onto North Martin Luther King Jr Street
0.1 mi·18 sec·North Martin Luther King Jr Street
27
Turn right onto Main Street
0.2 mi·33 sec·Main Street
28
Turn left onto South Commerce Street
142 ft·8 sec·South Commerce Street
29
Turn right onto Bracken Alley
347 ft·27 sec·Bracken Alley
30
Turn right onto South Pearl Street
128 ft·5 sec·South Pearl Street
31
Arrive at destination
South Pearl Street
Trip Plan
Given the 4-hour 15-minute drive time, starting your trip from Biloxi in the morning will allow you ample time to reach Natchez before evening. The fuel cost is estimated at $34, so ensure your tank is full before you depart. While there's only one designated stop, you can easily add more brief breaks as needed due to the manageable distance. Keep an eye on your fuel gauge, especially during the 56.4-mile stretch on Congressman Jimmy Morrison Highway, to ensure you don't need to search for a station unexpectedly.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 112.8 miles from Biloxi, MS, or about 2h 6m into the drive.
The longest continuous stretch on this route runs about 56.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 50 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 112.8 miles or 2h 6m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 25m
Traffic, exits, and arrival timing usually matter more near Natchez, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 225.6 miles and 4h 15m.
Your first comfortable stop window is around 50 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Congressman Jimmy Morrison Highway for about 56.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 26
5 decision points cluster between mile 3.7 and 104.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
3.7 mi into trip|~7m in
Take the exit toward I 10: Mobile
Exit ramp - move to the correct lane early
Exit 4AB
Toward I 10: Mobile
7
3.9 mi into trip|~7m in
Keep slight right at fork toward Popps Ferry Road
Highway fork - watch signs carefully
Exit 4A
Toward Popps Ferry Road
5
4 mi into trip|~7m in|Big Ridge Road
At end of road, turn left onto Big Ridge Road
Navigation decision point
6
56.5 mi into trip|~1h 5m in|I 12 / West Florida Republic Parkway
Keep slight right at fork onto I 12 / West Florida Republic Parkway toward I 12, I 59: Hammond, Baton Rouge, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 12, I 59: Hammond, Baton Rouge, Hattie...
7
104.3 mi into trip|~1h 57m in
Take the exit toward I 55: Jackson
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 38B
Toward I 55: Jackson
Fuel & Cost
Regular Gas
$34.07 one way
$68.14 round trip
$3.84/gal25.4 MPG avg79 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$37.40
$74.80
premium
$4.56
$40.49
$80.99
diesel
$5.61
$49.81
$99.62
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$34
Meals
$25–$50
Total
$59–$84
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 78.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $24 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
67.7
0
$23.69
$10.83
Efficient EV
56.4
0
$19.74
$9.02
EV Truck/SUV
90.2
1
$31.58
$14.44
Gas CO2
79 kg
EV CO2
26 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Biloxi, MS
Night
in Biloxi on Saturday
Local time
11:35 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Natchez, MS
Night
in Natchez on Saturday
Local time
11:35 PM
CDT
Current temp
79°F
Unavailable
Live forecast
82°F
Hammond, LA
113 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
18 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 15m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Natchez National Historical Park
National Historical Park
Discover the history of all the peoples of Natchez, Mississippi, from European settlement, African enslavement, the American cotton economy, to the Civil Rights struggle on the lower Mississippi River...
1 mi from route
~3 min detour
Free
near mile 225.6
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is predominantly a highway-focused drive, with 72% of the journey utilizing major roadways like Congressman Jimmy Morrison Highway and I-10. You'll encounter stretches where the speed limit is higher and the pace is quicker, particularly on the longest uninterrupted stretch of 56.4 miles on Congressman Jimmy Morrison Highway. While much of the drive is on these main arteries, the overall character is one of steady progress rather than winding scenic byways. It’s a functional drive designed for covering ground efficiently.
72% highway — fuel and pacing are the main things to plan.
31 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 56.4 mi on Congressman Jimmy Morrison Highway.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Congressman Jimmy Morrison Highway and I 10. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 3.7 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 26 significant decision points across 225.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 3.7 miles: Exit ramp - move to the correct lane early; at 3.9 miles: Highway fork - watch signs carefully; at 4 miles (Big Ridge Road): Navigation decision point.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Natchez, MS, road signs point toward Baton Rouge and Hattiesburg.
Baton Rouge
56.5 mi in|~1h 5m|via I 12
Hattiesburg
56.5 mi in|~1h 5m|via I 12
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 15m. Total distance: 225.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 15m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (72%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 56.4 miles on Congressman Jimmy Morrison Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Natchez, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 3.7 miles: Exit ramp - move to the correct lane early; at 3.9 miles: Highway fork - watch signs carefully; at 4 miles (Big Ridge Road): Navigation decision point.
Yes — Natchez National Historical Park. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.3 hours each way, an in-and-out day trip would put you behind the wheel for 8.5 hours — manageable with a long break at Natchez, MS, but most travelers stay overnight.
