This 235.7-mile journey from Belzoni, MS to Biloxi, MS is a straightforward, highway-focused drive that can comfortably be completed in under 5 hours. With an estimated fuel cost of $36, this route is an excellent option for a single-day road trip. You'll primarily be on Highway 49 South and US 49, making up about 79% of the drive. The route stays within the Southeast region, offering a consistent feel as you travel south. This trip is well-suited for those looking for an efficient drive with minimal fuss.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
117.9 miles from Belzoni, MS
A natural place for your longest stop of the day
, about 2h 25m into the drive
.
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
US 49
53.4 mi
1h 4m
Jerry Clower Boulevard
38.8 mi
47m
US 49W
24.1 mi
29m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Turn-by-Turn Driving Directions
Step-by-step road directions between Belzoni, MS and Biloxi, MS.
1
Start on MS 7
221 ft·8 sec·Martin Luther King Drive
2
Turn right onto MS 7
0.4 mi·44 sec·1st Street
3
Turn left onto US 49W; MS 12
24 mi·28 min·US 49W; MS 12
4
Keep slight right at fork onto US 49W
0.5 mi·53 sec·US 49W
Toward US 49 South: Jackson
5
Merge onto US 49
39 mi·47 min·Jerry Clower Boulevard
6
Take the exit onto US 49
4.9 mi·5 min·US 49
7
Keep slight left at fork onto US 49
3.8 mi·5 min·US 49
8
Merge onto I 20; I 55; US 49
1.1 mi·1 min·I 20; I 55; US 49
9
Keep slight right at fork onto I 20; US 49
347 ft·4 sec·I 20; US 49
Toward Meridian, Hattiesburg
10
Take the exit onto US 49
0.6 mi·42 sec·US 49
Toward Hattiesburg
11
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
12
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
13
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
14
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
15
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
16
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
17
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
18
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
19
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
20
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
21
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
22
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
23
Continue on I 110
3.2 mi·4 min·I 110
24
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
25
Turn left onto Division Street
0.6 mi·1 min·Division Street
26
Turn right onto Main Street
0.5 mi·1 min·Main Street
27
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
28
Arrive at destination
Howard Avenue
Trip Plan
Given the 4 hour and 49 minute duration, starting your drive in Belzoni after breakfast is a good plan to arrive in Biloxi with ample daylight. With only one recommended stop, you have flexibility in pacing yourself. Keep an eye on your fuel levels, especially during the longest stretch of 80.3 miles on Highway 49 South. This is a direct drive, so a quick check of local traffic conditions before you depart can help you avoid any unexpected delays on US 49.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 117.9 miles from Belzoni, MS, or about 2h 25m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 52 miles or 1h 3m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 117.9 miles or 2h 25m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 56m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Belzoni, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Belzoni, MS
This is one driving day of about 235.7 miles and 4h 49m.
Your first comfortable stop window is around 52 miles from Belzoni, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 20
5 decision points cluster between mile 73.1 and 167.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
73.1 mi into trip|~1h 30m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Meridian, Hattiesburg
7
156.2 mi into trip|~3h 12m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
164.4 mi into trip|~3h 21m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
167.5 mi into trip|~3h 25m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
167.8 mi into trip|~3h 26m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Fuel & Cost
Regular Gas
$35.60 one way
$71.19 round trip
$3.84/gal25.4 MPG avg83 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$39.08
$78.15
premium
$4.56
$42.31
$84.61
diesel
$5.61
$52.04
$104.08
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$36
Meals
$25–$50
Total
$61–$86
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 82.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $25 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
70.7
0
$24.75
$11.31
Efficient EV
58.9
0
$20.62
$9.43
EV Truck/SUV
94.3
1
$33.00
$15.08
Gas CO2
82 kg
EV CO2
28 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Belzoni, MS
Morning
in Belzoni on Tuesday
Local time
7:41 AM
CDT
Current temp
64°F
Unavailable
Live forecast
Destination
Biloxi, MS
Morning
in Biloxi on Tuesday
Local time
7:41 AM
CDT
Current temp
78°F
Unavailable
Live forecast
58°F
Sumrall, MS
118 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
14 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 49m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a predominantly highway-focused experience on this route, with 79% of the journey utilizing major highways like Highway 49 South and US 49. The longest uninterrupted stretch you'll encounter is 80.3 miles, allowing for sustained progress. While much of the drive is on these main arteries, you'll also navigate sections like Jerry Clower Boulevard. The road character remains largely consistent, emphasizing forward momentum over winding scenic byways.
79% highway — fuel and pacing are the main things to plan.
28 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80.3 mi on Highway 49 South.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Highway 49 South and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 73.1 miles in near I 20; US 49.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 235.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 73.1 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 156.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 164.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Belzoni, MS and Biloxi, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Mobile - among others.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Doable as a same-day drive at 4h 49m. Total distance: 235.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 49m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (79%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 80.3 miles on Highway 49 South. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Biloxi, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 73.1 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 156.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 164.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Possible but tiring. At 4.8 hours each way, an in-and-out day trip would put you behind the wheel for 9.6 hours — manageable with a long break at Biloxi, MS, but most travelers stay overnight.
