Traveling from Amory to Greenville covers 185.3 miles across Mississippi, making for a straightforward journey that typically takes about 4 hours and 7 minutes. Since this route is designed as a one-day trip, you can easily manage the drive without needing an overnight stay. Expect to spend roughly $28 on fuel, depending on your vehicle's efficiency. The route relies heavily on major thoroughfares like US 82, the Natchez Trace Parkway, and MS 8 to connect the two cities. Whether you are heading west for business or a change of scenery, this highway-focused drive provides a reliable link between these two Southeast locations.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
92.7 miles from Amory, MS
A natural place for your longest stop of the day
, about 2h 11m into the drive
.
Main Roads
Road
Distance
Duration
US 82
109.1 mi
2h 13m
Natchez Trace Parkway
15 mi
22m
MS 8
14.4 mi
21m
MS 15
11.5 mi
18m
US Highway 45 Alternate
10.8 mi
12m
MS 182
8.3 mi
12m
6th Avenue South
8.2 mi
12m
MS 41
4.5 mi
7m
Longest stretch:
US 82
— 109.1 mi, about 2h 13m
Turn-by-Turn Driving Directions
Step-by-step road directions between Amory, MS and City of Greenville, MS.
1
Start on 2nd Avenue South
47 ft·7 sec·2nd Avenue South
2
Turn left onto MS 25
0.4 mi·42 sec·South Main Street
3
Turn right onto US 278
8.2 mi·12 min·6th Avenue South
Use the straight / right lanes.
4
Continue on US 278
252 ft·3 sec·US 278
5
Continue on MS 41
4.1 mi·7 min·MS 41
Toward MS 41 North: Okalona
6
Continue on MS 41
0.4 mi·37 sec·MS 41
7
Take the ramp
0.4 mi·53 sec
Toward US 45 Alternate South: West PointUse the left lane.
8
Merge onto US 45 ALT
0.4 mi·25 sec·US 45 ALT
9
Continue on US 45 ALT
11 mi·12 min·US Highway 45 Alternate
10
Take the exit
0.4 mi·52 sec
Toward MS 8: Houston, Aberdeen
11
Turn right onto MS 8
14 mi·21 min·MS 8
12
Turn left onto Doss Drive
0.2 mi·43 sec·Doss Drive
13
At end of road, turn left onto Natchez Trace Parkway
15 mi·22 min·Natchez Trace Parkway
14
Turn right onto County Road 285
0.1 mi·30 sec·County Road 285
15
At end of road, turn left onto MS 15
9.5 mi·14 min·MS 15
16
Take the ramp onto MS 15
2.0 mi·3 min·MS 15
17
Continue on US 82
96 mi·1 hr 57 min·US 82
18
Keep slight left at fork onto US 82
0.4 mi·29 sec·US 82
19
Keep slight left at fork onto US 82
13 mi·15 min·US 82
20
Turn right onto MS 182
8.3 mi·12 min·MS 182
21
Turn left onto MS 1
1.0 mi·1 min·Martin Luther King Junior Boulevard
22
Turn right onto East Reed Road
0.7 mi·1 min·East Reed Road
23
Turn left onto Sandy Avenue
46 ft·2 sec·Sandy Avenue
24
Arrive at destination
Sandy Avenue
Trip Plan
Because this is a manageable 4-hour drive, you have the flexibility to depart at your leisure, though starting early helps you avoid mid-day traffic. Plan for at least one dedicated stop along the way to break up the 185.3-mile distance and stretch your legs. Keep a close eye on your fuel gauge, keeping in mind the $28 estimated cost, to ensure you remain fueled up during the long 109.1-mile stretch on US 82. Since this route is compact enough for a single day, focus your energy on the destination rather than worrying about mid-trip lodging. Utilizing the Natchez Trace Parkway and MS 8 effectively will keep your travel time predictable and efficient.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 92.7 miles from Amory, MS, or about 2h 11m into the drive.
The longest continuous stretch on this route runs about 109.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 41 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 92.7 miles or 2h 11m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 23m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Amory, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Amory, MS
This is one driving day of about 185.3 miles and 4h 7m.
Your first comfortable stop window is around 41 miles from Amory, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 82 for about 109.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 14
5 decision points cluster between mile 0.4 and 54.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
0.4 mi into trip|~0m in|US 278 / 6th Avenue South
Turn right onto US 278 / 6th Avenue South
Lane positioning matters here
Use the straight / right lanes.
5
13.1 mi into trip|~20m in
Take the ramp toward US 45 Alternate South: West Point
Lane positioning matters here
Use the left lane.
Toward US 45 Alternate South: West Point
5
24.6 mi into trip|~34m in
Take the exit toward MS 8: Houston, Aberdeen
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward MS 8: Houston, Aberdeen
4
39.4 mi into trip|~57m in|Doss Drive
Turn left onto Doss Drive
Navigation decision point
5
54.7 mi into trip|~1h 20m in|MS 15
At end of road, turn left onto MS 15
Navigation decision point
Fuel & Cost
Regular Gas
$27.98 one way
$55.97 round trip
$3.84/gal25.4 MPG avg65 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$30.72
$61.44
premium
$4.56
$33.26
$66.52
diesel
$5.61
$40.91
$81.82
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$28
Meals
$25–$50
Total
$53–$78
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 64.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $19 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
55.6
0
$19.46
$8.89
Efficient EV
46.3
0
$16.21
$7.41
EV Truck/SUV
74.1
0
$25.94
$11.86
Gas CO2
65 kg
EV CO2
22 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 11, 2026
Origin
Amory, MS
Night
in Amory on Saturday
Local time
11:49 PM
CDT
Current temp
85°F
Sunny
0 mph0% chanceLive forecast
Destination
City of Greenville, MS
Night
in City of Greenville on Saturday
Local time
11:49 PM
CDT
Current temp
84°F
Sunny
SSE 5 mph0% chanceLive forecast
52°F
Winona, MS
93 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 7m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
18 mi from route
~44 min detour
Free
near mile 12.8
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
23 mi from route
~57 min detour
Free
near mile 12.8
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a drive dominated by highway travel, with 94% of your journey spent on high-speed roads. The route transitions through varied stretches, most notably a 109.1-mile segment along US 82 that serves as the longest uninterrupted portion of the trip. While the road is optimized for efficiency, the shift between the Natchez Trace Parkway and local state routes offers a change of pace from the primary highway corridors. You will spend the vast majority of your time behind the wheel on well-traveled paths, ensuring a consistent experience as you traverse the state from east to west.
94% highway — fuel and pacing are the main things to plan.
24 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 109.1 mi on US 82.
How Hard Is This Drive?
4/10
This is a straightforward highway drive that stays mostly on US 82 and Natchez Trace Parkway. There are only a few real navigation decisions along the way. The trickiest moment comes around 0.4 miles in near US 278 / 6th Avenue South.
Driving Effort4/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 4h 7m drive. You will face about 14 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: at 0.4 miles (US 278 / 6th Avenue South): Lane positioning matters here; at 13.1 miles: Lane positioning matters here; at 24.6 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
468 ft119 ft
Total Climb
404 ft
Total Descent
518 ft
Highest Point
468 ft
~61.8 mi in
Elevation Range
349 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Amory, MS to City of Greenville, MS, road signs begin pointing toward Aberdeen along the way.
Aberdeen
24.6 mi in|~34m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 7m. Total distance: 185.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
The longest stretch is about 109.1 miles on US 82. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: at 0.4 miles (US 278 / 6th Avenue South): Lane positioning matters here; at 13.1 miles: Lane positioning matters here; at 24.6 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Yes — Tupelo National Battlefield and Natchez Trace National Scenic Trail. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.1 hours each way, an in-and-out day trip would put you behind the wheel for 8.3 hours — manageable with a long break at City of Greenville, MS, but most travelers stay overnight.
