This 239.3-mile journey from East Independence, MO, to Byrnes Mill, MO, will take approximately 4 hours and 46 minutes of driving time. Primarily utilizing highways like the Dwight D. Eisenhower Highway and the Avenue of the Saints, about 7% of this route involves local roads, making it a manageable one-day trip. With an estimated fuel cost of $36, this drive offers a straightforward way to travel within Missouri's Midwest region. You'll find this route has a moderate number of turns, so plan accordingly for a steady pace. The longest stretch you'll encounter is 135.3 miles on the Dwight D. Eisenhower Highway, allowing for some extended driving periods between changes.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
119.7 miles from East Independence, MO
A natural place for your longest stop of the day
, about 2h 15m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Avenue of the Saints
22 mi
26m
MO 141
8.5 mi
13m
MO 30
5.6 mi
7m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
South Little Blue Parkway
1.7 mi
3m
Hawkins Road
1.6 mi
3m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Turn-by-Turn Driving Directions
Step-by-step road directions between East Independence, MO and Byrnes Mill, MO.
1
Start on East 9th Street South
79 ft·8 sec·East 9th Street South
2
Turn left onto Main Road
0.3 mi·1 min·Main Road
3
Turn left onto East Truman Road
0.7 mi·1 min·East Truman Road
4
Turn right onto Holke Road
0.9 mi·1 min·Holke Road
5
Turn straight onto South Jackson Drive
1.2 mi·2 min·South Jackson Drive
6
Turn left onto East R.D. Mize Road
0.2 mi·37 sec·East R.D. Mize Road
7
Turn right onto South Little Blue Parkway
1.7 mi·3 min·South Little Blue Parkway
8
Take the ramp
0.3 mi·38 sec
Exit 17Toward Little Blue Parkway, 39th Street, Mall EntranceUse the left lane.
9
Continue on I 70
53 mi·56 min·Dwight D. Eisenhower Highway
10
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
15
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
16
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
17
Merge onto I 64; US 40; US 61
22 mi·26 min·Avenue of the Saints
Use the straight / slight left lanes.
18
Take the exit
0.3 mi·33 sec
Exit 22Toward MO 141Use the slight right lane.
19
Turn right
185 ft·5 sec
Toward MO 141: Manchester
20
Merge onto MO 141
8.5 mi·13 min·MO 141
Use the right lane.
21
Turn right onto Hawkins Road
1.6 mi·3 min·Hawkins Road
22
Continue on New Sugar Creek Road
1.0 mi·1 min·New Sugar Creek Road
23
Take the ramp
182 ft·2 sec
Toward MO 30 West
24
Merge onto MO 30
5.6 mi·7 min·MO 30
25
Take the exit
109 ft·3 sec
Toward Upper Byrnes Mill Road
26
Turn slight right onto Upper Byrnes Mill Road
1.4 mi·3 min·Upper Byrnes Mill Road
27
Arrive at destination
Upper Byrnes Mill Road
Trip Plan
Given the 4-hour and 46-minute duration, this trip is comfortably achievable in a single day. To make the most of your drive, consider departing in the morning to allow ample time for the approximately 239.3 miles. With only one recommended stop and an estimated fuel cost of $36, you have flexibility in pacing. Pay attention to the "turn-heavy local drive" profile, especially during the latter parts of the journey, as these changes can impact your estimated arrival time. The longest uninterrupted stretch of 135.3 miles on the Dwight D. Eisenhower Highway is a good opportunity for a longer driving segment before you might need to refuel or stretch your legs.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 119.7 miles from East Independence, MO, or about 2h 15m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 53 miles or 1h 3m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 119.7 miles or 2h 15m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 45m
Traffic, exits, and arrival timing usually matter more near Byrnes Mill, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving East Independence, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from East Independence, MO
This is one driving day of about 239.3 miles and 4h 46m.
Your first comfortable stop window is around 53 miles from East Independence, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 0 and 220.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|Main Road
Turn left onto Main Road
Navigation decision point
8
5 mi into trip|~10m in
Take the ramp toward Little Blue Parkway, 39th Street, Mall Entrance
Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Exit 17
Toward Little Blue Parkway, 39th Street, Mall E...
6
198.5 mi into trip|~3h 48m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
5
198.8 mi into trip|~3h 49m in|I 64; US 40; US 61 / Avenue of the Saints
Merge onto I 64; US 40; US 61 / Avenue of the Saints
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight left lanes.
7
220.8 mi into trip|~4h 15m in
Take the exit toward MO 141
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 22
Toward MO 141
Fuel & Cost
Regular Gas
$37.41 one way
$74.82 round trip
$3.97/gal25.4 MPG avg84 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$41.08
$82.15
premium
$4.89
$46.05
$92.10
diesel
$5.61
$52.83
$105.67
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$37
Meals
$25–$50
Total
$62–$87
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 83.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $25 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
71.8
0
$25.13
$11.49
Efficient EV
59.8
0
$20.94
$9.57
EV Truck/SUV
95.7
1
$33.50
$15.32
Gas CO2
84 kg
EV CO2
28 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 14, 2026
Origin
East Independence, MO
Night
in East Independence on Saturday
Local time
11:23 PM
CDT
Current temp
68°F
Chance Showers And Thunderstorms then Partly Cloudy
SSW 18 mph52% chanceLive forecast
Destination
Byrnes Mill, MO
Night
in Byrnes Mill on Saturday
Local time
11:23 PM
CDT
Current temp
68°F
Partly Cloudy
SW 8 to 12 mph8% chanceLive forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
4h 46m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
17 mi from route
~44 min detour
$19
near mile 222.8
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a "turn-heavy local drive" feel for a portion of this route, despite a significant 7% highway share. While you'll experience stretches on major roads like the Dwight D. Eisenhower Highway and the U.S. Submarine Veterans' Memorial Highway, the profile suggests a character that blends highway speeds with more frequent directional changes typical of local navigation. The longest continuous segment spans 135.3 miles on the Dwight D. Eisenhower Highway, offering a period of consistent travel. This mix means you'll need to stay engaged as the road character shifts, transitioning between faster-paced highway driving and more intricate local road segments.
Only 7% highway — the rest is turn-by-turn surface driving.
27 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
6/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 15 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near Main Road.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 239.3 miles you will encounter 15 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (Main Road): Navigation decision point; at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 46m. Total distance: 239.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 46m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 135.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Byrnes Mill, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (Main Road): Navigation decision point; at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Yes — Gateway Arch National Park. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.8 hours each way, an in-and-out day trip would put you behind the wheel for 9.5 hours — manageable with a long break at Byrnes Mill, MO, but most travelers stay overnight.
