Desloge, MO to East Independence, MO is 287.7 miles and takes about 5h 35m via Dwight D Eisenhower Highway, with a fuel budget near $45 and enough daylight to finish in a day. This drive stays within Missouri, connecting two points in the Midwest region. With only one recommended stop and a profile described as turn-heavy local drive, this route is best suited for those who prefer a more involved driving experience over simply cruising on an interstate. It's a solid choice for a single-day trip if you're looking for a straightforward journey.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
143.9 miles from Desloge, MO
A natural place for your longest stop of the day
, about 2h 51m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D Eisenhower Highway
80.7 mi
1h 35m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Dwight D. Eisenhower Highway
54.3 mi
58m
US 67
26.6 mi
30m
Avenue of the Saints
25.4 mi
30m
I 55
20.5 mi
22m
I 270
11.5 mi
14m
Sheriff Roger I. Wilson Memorial Highway
2 mi
2m
Longest stretch:
Dwight D Eisenhower Highway
— 80.7 mi, about 1h 35m
Turn-by-Turn Driving Directions
Step-by-step road directions between Desloge, MO and East Independence, MO.
1
Start on Chestnut Street
262 ft·17 sec·Chestnut Street
2
Turn left onto US 67 Business; MO 8
1.5 mi·2 min·North Desloge Drive
3
Take the ramp
0.2 mi·21 sec
Toward US 67 North: Saint Louis
4
Merge onto US 67
26 mi·30 min·US 67
5
Keep slight right at fork onto US 67
0.3 mi·27 sec·US 67
6
Take the exit
0.3 mi·49 sec
Toward I 55 North: Saint Louis
7
Merge onto I 55
21 mi·22 min·I 55
8
Continue on I 55
1.3 mi·1 min·Rosa Parks Highway
9
Take the exit
0.2 mi·27 sec
Exit 196Toward I 270 West, I 255 East: Kansas City, ChicagoUse the slight right lane.
10
Keep slight left at fork
388 ft·8 sec
Toward I 270 West: Kansas CityUse the slight left lane.
11
Continue on this road
0.7 mi·1 min·this road
Exit 196Toward I 270 West
12
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
13
Take the exit
0.1 mi·17 sec
Exit 12Toward I 64, US 40, US 61: Wentzville, Saint LouisUse the slight right lane.
14
Keep slight left at fork
0.4 mi·48 sec
Toward I 64 West, US 40 West, US 61 North: WentzvilleUse the slight left lane.
15
Continue on this road
0.1 mi·9 sec·this road
Exit 12Toward I 64 West, US 40 West, US 61 North: Wentzville
16
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight lane.
17
Take the exit onto US 40
0.6 mi·1 min·US 40
Exit 1AToward I 70 West, US 40 West: Kansas CityUse the straight / slight left lanes.
18
Merge onto I 70; US 40
81 mi·1 hr 35 min·Dwight D Eisenhower Highway
19
Continue on I 70; US 40
2.0 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
20
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
21
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
22
Continue on I 70; US 40
54 mi·58 min·U.S. Submarine Veterans' Memorial Highway
23
Continue on I 70; US 40
52 mi·56 min·Dwight D. Eisenhower Highway
24
Take the exit
0.3 mi·40 sec
Exit 17Toward Little Blue Parkway, 39th Street, Mall EntranceUse the slight right lane.
25
Turn right onto South Little Blue Parkway
1.6 mi·3 min·South Little Blue Parkway
26
Turn left onto East R.D. Mize Road
0.2 mi·37 sec·East R.D. Mize Road
27
Turn right onto South Jackson Drive
1.2 mi·2 min·South Jackson Drive
28
Turn straight onto Holke Road
0.9 mi·2 min·Holke Road
29
Turn left onto East Truman Road
0.7 mi·1 min·East Truman Road
30
Turn right onto Main Road
0.3 mi·1 min·Main Road
31
Turn right onto East 9th Street South
79 ft·3 sec·East 9th Street South
32
Arrive at destination
East 9th Street South
Trip Plan
Given the 5h 35m estimated drive time and a turn-heavy profile, consider starting your trip in the morning to allow ample daylight for navigation. While this route is manageable in one day, there's only one recommended stop, so plan your breaks accordingly. Keep an eye on your fuel gauge, especially as you transition between highway and local roads, with an estimated fuel cost of around $45. Don't rush the local road sections; they often require more attention than interstate driving.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 143.9 miles from Desloge, MO, or about 2h 51m into the drive.
The longest continuous stretch on this route runs about 80.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 63 miles or 1h 14m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 143.9 miles or 2h 51m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 34m
Traffic, exits, and arrival timing usually matter more near East Independence, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Desloge, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Desloge, MO
This is one driving day of about 287.7 miles and 5h 35m.
Your first comfortable stop window is around 63 miles from Desloge, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D Eisenhower Highway for about 80.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 22
5 decision points cluster between mile 50.5 and 89.1 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
50.5 mi into trip|~58m in
Take the exit toward I 270 West, I 255 East: Kansas City, Chicago
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 196
Toward I 270 West, I 255 East: Kansas City, Chi...
8
50.7 mi into trip|~59m in
Keep slight left at fork toward I 270 West: Kansas City
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left lane.
Toward I 270 West: Kansas City
8
63 mi into trip|~1h 14m in
Take the exit toward I 64, US 40, US 61: Wentzville, Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 12
Toward I 64, US 40, US 61: Wentzville, Saint Lo...
8
63.2 mi into trip|~1h 15m in
Keep slight left at fork toward I 64 West, US 40 West, US 61 North: Wentzville
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 64 West, US 40 West, US 61 North: Went...
8
89.1 mi into trip|~1h 46m in|US 40
Take the exit onto US 40 toward I 70 West, US 40 West: Kansas City
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Exit 1A
Toward I 70 West, US 40 West: Kansas City
Fuel & Cost
Regular Gas
$44.98 one way
$89.96 round trip
$3.97/gal25.4 MPG avg101 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$49.38
$98.77
premium
$4.89
$55.37
$110.73
diesel
$5.61
$63.52
$127.04
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$45
Meals
$25–$50
Total
$70–$95
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 100.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $30 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
86.3
1
$30.21
$13.81
Efficient EV
71.9
0
$25.17
$11.51
EV Truck/SUV
115.1
1
$40.28
$18.41
Gas CO2
101 kg
EV CO2
34 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 17, 2026
Origin
Desloge, MO
Night
in Desloge on Saturday
Local time
9:47 PM
CDT
Current temp
82°F
Unavailable
Live forecast
Destination
East Independence, MO
Night
in East Independence on Saturday
Local time
9:47 PM
CDT
Current temp
82°F
Showers And Thunderstorms
SSW 18 to 22 mph78% chanceLive forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
5h 35m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
13 mi from route
~33 min detour
$19
near mile 49.6
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
25 mi from route
~63 min detour
Free
near mile 29.8
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This is a turn-heavy local drive, meaning you'll experience more frequent course corrections than on a pure interstate journey. Only 21% of this route utilizes highway driving, so expect a significant portion to involve navigating local roads. The longest uninterrupted stretch you'll encounter is 80.7 miles along the Dwight D Eisenhower Highway. This suggests a dynamic route that likely shifts between faster highway segments and more winding, potentially slower, local road sections as you progress.
Only 21% highway — the rest is turn-by-turn surface driving.
32 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80.7 mi on Dwight D Eisenhower Highway.
How Hard Is This Drive?
10/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 50.5 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 22 significant decision points across 287.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 50.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 50.7 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 63 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Desloge, MO and East Independence, MO, road signs point toward Chicago and Saint Louis.
Chicago
50.5 mi in|~58m
Saint Louis
63 mi in|~1h 14m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 35m. Total distance: 287.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 35m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 80.7 miles on Dwight D Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at East Independence, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 50.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 50.7 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 63 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Gateway Arch National Park and Ste. Geneviève National Historical Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.6 hours each way, a round trip means 11.2 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at East Independence, MO before the return drive.
