Origin
Chesterfield, MO
Night in Chesterfield on Saturday
Local time
9:46 PM
CDT
Current temp
57°F
Unavailable
Live forecast
Trip from Chesterfield, MO to De Soto, MO
Compiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Apr 19, 2026 · Editorial standards
Drive Time
1h 4m
Distance
46.9 mi
75 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$7
one way
EV Charging
Unknown
Best Time to Leave
4 AM
0h 59m
★
6 AM
1h 4m
8 AM
1h 14m
10 AM
1h 8m
12 PM
1h 7m
3 PM
1h 8m
5 PM
1h 14m
8 PM
1h 1m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Chesterfield, MO
Wikimedia Commons
De Soto, MO
Wikimedia Commons
Trip Overview
This 46.9-mile drive from Chesterfield, MO, to De Soto, MO, is a straightforward 1-hour journey perfect for a day trip. You'll primarily travel on Veterans Memorial Highway and MO 21, with about 44% of your time spent on highways. The estimated fuel cost for this short trip is around $7, making it an economical option. Given the short distance and duration, it's easy to complete in a single day, allowing for flexibility in your schedule. This route stays within the Midwest region, offering a familiar drive through Missouri.
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Veterans Memorial Highway | 19.8 mi | 23m |
| MO 141 | 14.9 mi | 23m |
| MO 21 | 4.4 mi | 6m |
| Avenue of the Saints | 3.7 mi | 4m |
| MO 110 | 1.5 mi | 1m |
| North Main Street | 1.4 mi | 2m |
| Baxter Road | 0.3 mi | <1m |
| Old Chesterfield Road | 0.1 mi | <1m |
Longest stretch:
Veterans Memorial Highway
— 19.8 mi, about 23m
Turn-by-Turn Driving Directions
Step-by-step road directions between Chesterfield, MO and De Soto, MO.
1
Start on Santa Maria Drive
107 ft
·
8 sec
·
Santa Maria Drive
2
Turn left onto Old Chesterfield Road
0.1 mi
·
32 sec
·
Old Chesterfield Road
3
Turn right onto Baxter Road
0.3 mi
·
36 sec
·
Baxter Road
4
Take the ramp
0.2 mi
·
23 sec
Toward I 64 East, US 40 East, US 61 South
5
Merge onto I 64; US 40; US 61
3.7 mi
·
4 min
·
Avenue of the Saints
Use the straight lane.
6
Take the exit
0.3 mi
·
33 sec
Exit 22
Toward MO 141
Use the slight right lane.
7
Turn right
185 ft
·
5 sec
Toward MO 141: Manchester
8
Merge onto MO 141
11 mi
·
17 min
·
MO 141
Use the right lane.
9
Keep slight left at fork onto MO 141
4.0 mi
·
5 min
·
MO 141
Use the left / straight lanes.
10
Take the exit
0.2 mi
·
13 sec
Toward MO 21 South: Hillsboro
11
Merge onto MO 21
20 mi
·
23 min
·
Veterans Memorial Highway
12
At end of road, turn left onto MO 21; MO B
0.5 mi
·
49 sec
·
MO 21; MO B
13
Continue on MO 21
3.9 mi
·
5 min
·
MO 21
14
Turn left onto MO 110
1.5 mi
·
1 min
·
MO 110
15
Turn right onto North Main Street
1.4 mi
·
2 min
·
North Main Street
16
Turn right onto Easton Street
435 ft
·
19 sec
·
Easton Street
17
Arrive at destination
Easton Street
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Mid-route town
Meal stop
23 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 10 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 23.4 miles from Chesterfield, MO, which is a good place for a longer meal and fuel stop.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Heads-up: tricky spots
5 of 145 decision points cluster between mile 0.4 and 15.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0.4 mi into trip
|
~1m in
Take the ramp toward I 64 East, US 40 East, US 61 South
Multiple destination signs - pick the right one
Toward I 64 East, US 40 East, US 61 South
5
0.6 mi into trip
|
~1m in
|
I 64; US 40; US 61 / Avenue of the Saints
Merge onto I 64; US 40; US 61 / Avenue of the Saints
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
7
4.3 mi into trip
|
~6m in
Take the exit toward MO 141
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 22
Toward MO 141
5
4.6 mi into trip
|
~6m in
Turn right toward MO 141: Manchester
Navigation decision point
Toward MO 141: Manchester
6
15.6 mi into trip
|
~24m in
|
MO 141
Keep slight left at fork onto MO 141
Highway fork - watch signs carefully. Lane positioning matters here
Use the left / straight lanes.
Fuel & Cost
Regular Gas
$7.33 one way
$14.66 round trip
$3.97/gal
25.4 MPG avg
16 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $8.05 | $16.10 |
| premium | $4.89 | $9.03 | $18.05 |
| diesel | $5.61 | $10.35 | $20.71 |
No toll roads detected on this route.
Drive Cost (one way)
Fuel
$7
Estimated CO2 emission: 16.4 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $5 in charging · 0 stops · 69% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 14.1 | 0 | $4.92 | $2.25 |
| Efficient EV | 11.7 | 0 | $4.10 | $1.88 |
| EV Truck/SUV | 18.8 | 0 | $6.57 | $3.00 |
Gas CO2
16 kg
EV CO2
5 kg (69% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
De Soto, MO
Night in De Soto on Saturday
Local time
9:46 PM
CDT
Current temp
55°F
Unavailable
Live forecast
80°F
Fenton, MO
23 mi in
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
1h 4m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
What kind of drive is this?
The drive presents a mixed profile, combining highway speeds with more local road conditions. You'll experience a 44% highway share, but the longest uninterrupted stretch is 19.8 miles on Veterans Memorial Highway, suggesting some transitions between road types. Expect a varied driving experience as you navigate these Missouri roadways. This isn't a constant interstate grind; rather, it's a blend that keeps things interesting without being overly demanding.
44% highway, the rest on surface roads — varied driving throughout.
17 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 19.8 mi on Veterans Memorial Highway.
How Hard Is This Drive?
7/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.4 miles in.
Driving Effort
7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 46.9 miles you will encounter 14 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 0.4 miles: Multiple destination signs - pick the right one; at 0.6 miles (I 64; US 40; US 61 / Avenue of the Saints): Merge point - match speed before joining. Lane positioning matters here; at 4.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 1h 4m. Total distance: 46.9 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
1h 4m drive, comfortable solo distance.
EV Driver
0 DC fast chargers along the route. Coverage: unknown.
First-Time Driver
Mostly highway driving (44%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 19.8 miles on Veterans Memorial Highway. The full list of main roads is in the Roads section above.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at De Soto, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Yes. At under 2 hours behind the wheel, this works well for families — plan one quick stop if you have younger kids.
The main spots that need attention: at 0.4 miles: Multiple destination signs - pick the right one; at 0.6 miles (I 64; US 40; US 61 / Avenue of the Saints): Merge point - match speed before joining. Lane positioning matters here; at 4.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Yes. A round trip is manageable in a single day if you plan a break at De Soto, MO before heading back.
How this page is built
Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, and EIA for fuel prices. See our methodology for refresh cadence and limitations.
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