Biloxi to Yazoo City is 209 miles and takes about 4 hours 20 minutes via US 49 and MS 15, with a fuel budget near $31 and enough daylight to finish in a day. This trip stays within Mississippi, moving from the Southeast region to the same region. It's a straightforward drive that's mostly highway, making it a practical option for a single-day trip. You'll find it's a convenient way to cover ground within the state without needing an overnight stay.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
104.5 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 2h 10m into the drive
.
Main Roads
Road
Distance
Duration
US 49
140.6 mi
2h 53m
Medgar Evers Boulevard
36.1 mi
43m
MS 15
20.7 mi
24m
I 20
4.3 mi
5m
I 110
3.1 mi
4m
East Broadway Street
1.6 mi
3m
Division Street
0.5 mi
1m
Main Street
0.5 mi
1m
Longest stretch:
US 49
— 140.6 mi, about 2h 53m
Traffic on I-20
Hour-of-day weekday pattern from 14 FHWA count stations on your route.
Peak
7 AM
~2,710 veh/hr typical
· worst 4,827
Quietest
2 AM
~220 veh/hr
Peak-to-quiet ratio
12.3×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 51 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Yazoo City, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
17
Take the exit onto US 49
0.2 mi·21 sec·US 49
18
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
19
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
20
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
21
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
22
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
23
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
24
Merge onto US 49
36 mi·43 min·Medgar Evers Boulevard
25
Turn left onto MS 16; MS 149
1.6 mi·3 min·East Broadway Street
26
Turn right onto North Washington Street
0.3 mi·45 sec·North Washington Street
27
Turn right onto East Canal Street
0.2 mi·39 sec·East Canal Street
28
Turn left onto Grand Avenue
0.3 mi·46 sec·Grand Avenue
29
Turn left onto East 5th Street
64 ft·2 sec·East 5th Street
30
Arrive at destination
East 5th Street
Trip Plan
Given the 4-hour 20-minute duration, leaving Biloxi in the morning will comfortably get you to Yazoo City the same day. The single recommended stop is likely sufficient for a break, but you have flexibility if you prefer more frequent pauses. With 81% of the drive on highways, be mindful of the longest stretch of 140.6 miles on US 49, which means you'll want to ensure you have adequate fuel before starting that segment. Keep an eye out for the transition from highway to surface roads as you approach your destination.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 104.5 miles from Biloxi, MS, or about 2h 10m into the drive.
The longest continuous stretch on this route runs about 140.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 46 miles or 57m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 104.5 miles or 2h 10m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 33m
Traffic, exits, and arrival timing usually matter more near Yazoo City, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 209 miles and 4h 20m.
Your first comfortable stop window is around 46 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 140.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 25.1 and 164.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
158.9 mi into trip|~3h 17m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
6
162.2 mi into trip|~3h 21m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
5
164.9 mi into trip|~3h 25m in|US 49
Take the exit onto US 49 toward I 220 North, I 49 North: North Jackson, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 220 North, I 49 North: North Jackson,...
Fuel & Cost
Regular Gas
$32.12 one way
$64.25 round trip
$3.90/gal25.4 MPG avg73 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.32
$35.53
$71.06
premium
$4.65
$38.24
$76.47
diesel
$5.35
$44.02
$88.04
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$32
Meals
$25–$50
Total
$57–$82
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 73.1 kg one way.
Prices: EIA weekly data, 2026-06-01.
Driving Electric?
About $22 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
62.7
0
$21.95
$10.03
Efficient EV
52.3
0
$18.29
$8.36
EV Truck/SUV
83.6
1
$29.26
$13.38
Gas CO2
73 kg
EV CO2
24 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jun 2, 2026
Origin
Biloxi, MS
Afternoon
in Biloxi on Wednesday
Local time
3:05 PM
CDT
Current temp
88°F
Chance Showers And Thunderstorms
S 5 mph52% chanceLive forecast
Special Weather Statement
Special Weather Statement issued June 2 at 5:12PM CDT by NWS Jackson MS
Special Weather Statement
Special Weather Statement issued June 2 at 5:01PM CDT by NWS Jackson MS
Destination
Yazoo City, MS
Afternoon
in Yazoo City on Wednesday
Local time
3:05 PM
CDT
Current temp
90°F
Chance Showers And Thunderstorms
NNE 5 mph47% chanceLive forecast
Special Weather Statement
Special Weather Statement issued June 2 at 5:12PM CDT by NWS Jackson MS
Special Weather Statement
Special Weather Statement issued June 2 at 5:01PM CDT by NWS Jackson MS
72°F
New Haven, MS
105 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 20m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
3 mi from route
~9 min detour
Free
near mile 165.7
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is predominantly highway, with 81% of the drive on higher-speed roads. You'll experience a long stretch of 140.6 miles on US 49, indicating extended periods of consistent cruising. After this, you'll transition to surface roads, including Medgar Evers Boulevard and MS 15, for the remainder of the trip. Expect frequent exits and changes in speed as you enter more populated areas and navigate through towns.
81% highway — fuel and pacing are the main things to plan.
30 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 140.6 mi on US 49.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on US 49 and Medgar Evers Boulevard. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 209 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Elevation Profile
Mostly flat terrain
405 ft20 ft
Total Climb
557 ft
Total Descent
467 ft
Highest Point
405 ft
~119.4 mi in
Elevation Range
385 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Biloxi, MS to Yazoo City, MS, road signs begin pointing toward Jackson along the way.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Top landmarks
•Jefferson Davis Presidential Library and Museum — presidential library and museum for Confederate States President Jefferson Davis...
•Beauvoir — post-war home of the former President of the Confederate States of America, Jeff...
•Biloxi Light — lighthouse in Mississippi, United States
Doable as a same-day drive at 4h 20m. Total distance: 209 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 20m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (81%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 140.6 miles on US 49. The full list of main roads is in the Roads section above.
Yes — we found about 8 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Yazoo City, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 8 rest areas along the route for bathroom stops.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.3 hours each way, an in-and-out day trip would put you behind the wheel for 8.7 hours — manageable with a long break at Yazoo City, MS, but most travelers stay overnight.
