Traveling from Biloxi to Starkville covers 266.2 miles and typically takes about 4 hours and 4 minutes of driving time. Because this route is a turn-heavy local drive rather than a straight interstate shot, it is best suited as a single-day trip. You should budget approximately $41 for fuel to complete the journey. Navigating through the Southeast, you will transition from the coast toward the interior of Mississippi. Since there are no major highway stretches, the drive requires your full attention on local roads like Main Street, Division Street, and Bohn Street. It is a straightforward trip if you prefer a slower, more deliberate pace rather than high-speed interstate travel.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
132 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 2h 33m into the drive
.
Main Roads
Road
Distance
Duration
Lance Corporal Roy M Wheat Memorial Highway
88.4 mi
1h 35m
US 45
65.1 mi
1h 14m
US 49
42.2 mi
49m
MS 15
20.7 mi
24m
US Highway 45 Alternate
18.5 mi
21m
I 59
9 mi
10m
US 98
3.3 mi
4m
I 110
3.1 mi
4m
Longest stretch:
Lance Corporal Roy M Wheat Memorial Highway
— 88.4 mi, about 1h 35m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Starkville, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Take the exit
0.3 mi·51 sec
12
Merge onto US 98
2.5 mi·2 min·US 98
Use the straight / slight right lanes.
13
Take the exit onto US 98
0.8 mi·1 min·US 98
Toward I 59 North, US 98 West: Columbia, LaurelUse the straight / slight right lanes.
14
Merge onto I 59; US 98
88 mi·1 hr 35 min·Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
15
Keep slight right at fork onto I 59
9.0 mi·10 min·I 59
Toward I 59 North, I 20 East: Meridian, TuscaloosaUse the straight lane.
16
Take the exit
0.3 mi·47 sec
Toward US 45 North: MaconUse the slight right lane.
17
Merge onto US 45
65 mi·1 hr 14 min·US 45
Use the straight lane.
18
Keep slight left at fork onto US 45 ALT
19 mi·21 min·US Highway 45 Alternate
Toward US 45 Alternate North: West Point, TupeloUse the straight / slight left lanes.
19
Take the exit
6.6 mi·7 min
Toward US 82 West, MS 12 West, MS 25 South: Starkville
20
Take the exit
0.3 mi·50 sec
Toward MS 182 West: Starkville
21
Continue on MS 182
2.2 mi·3 min·MS 182
Use the straight / right lanes.
22
Turn left
0.2 mi·23 sec
Toward MS 12 West: AckermanUse the left lane.
23
Turn straight onto MS 12
1.7 mi·2 min·MS 12
24
Turn slight left
78 ft·5 sec
25
Turn left onto Eckford Drive
0.1 mi·34 sec·Eckford Drive
26
Continue on Victory Lane
0.2 mi·38 sec·Victory Lane
27
Turn right
214 ft·17 sec
28
Turn right
290 ft·21 sec
29
Arrive at destination
Trip Plan
Planning for this trip requires accounting for the turn-heavy nature of the local roads, so factor in a little extra time for navigating intersections. Aim to depart early in the morning to ensure you reach Starkville with plenty of daylight to spare, as local roads can be more challenging to navigate after dark. With only one recommended stop, try to time your break to coincide with the midpoint of your 4-hour and 4-minute travel time to keep your energy levels consistent. Keep your $41 fuel budget handy and fill up before leaving Biloxi to avoid searching for stations on unfamiliar local streets. Since the route relies on navigation through Main Street and other local thoroughfares, double-check your GPS settings to ensure you are routed correctly through these specific town corridors.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 132 miles from Biloxi, MS, or about 2h 33m into the drive.
The longest continuous stretch on this route runs about 88.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 58 miles or 1h 11m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 132 miles or 2h 33m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 9m
Traffic, exits, and arrival timing usually matter more near Starkville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 263.9 miles and 5h 8m.
Your first comfortable stop window is around 58 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Lance Corporal Roy M Wheat Memorial Highway for about 88.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 20
5 decision points cluster between mile 25.1 and 261.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
7
70.4 mi into trip|~1h 26m in|US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
159.6 mi into trip|~3h 3m in|I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
8
234 mi into trip|~4h 29m in|US 45 ALT / US Highway 45 Alternate
Keep slight left at fork onto US 45 ALT / US Highway 45 Alternate toward US 45 Alternate North: West Point, Tupelo
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Toward US 45 Alternate North: West Point, Tupel...
7
261.6 mi into trip|~5h 3m in
Turn left toward MS 12 West: Ackerman
Lane positioning matters here
Use the left lane.
Toward MS 12 West: Ackerman
Fuel & Cost
Regular Gas
$39.86 one way
$79.71 round trip
$3.84/gal25.4 MPG avg92 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$43.75
$87.50
premium
$4.56
$47.37
$94.73
diesel
$5.61
$58.27
$116.53
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$40
Meals
$25–$50
Total
$65–$90
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 92.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $28 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
79.2
0
$27.71
$12.67
Efficient EV
66
0
$23.09
$10.56
EV Truck/SUV
105.6
1
$36.95
$16.89
Gas CO2
92 kg
EV CO2
31 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Biloxi, MS
Morning
in Biloxi on Tuesday
Local time
7:41 AM
CDT
Current temp
78°F
Unavailable
Live forecast
Destination
Starkville, MS
Morning
in Starkville on Tuesday
Local time
7:41 AM
CDT
Current temp
84°F
Unavailable
Live forecast
82°F
Meridian, MS
132 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
6 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 8m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a highly tactile experience behind the wheel, as this route consists entirely of local roads with 0% highway share. The drive is characterized by frequent turns rather than long, straight stretches, demanding a more engaged driving style compared to a typical motorway commute. Because the route relies on streets like Bohn Street and Division Street, you will find yourself navigating through local transitions rather than maintaining a constant cruise control speed. This 266.2-mile journey offers a consistent feel from start to finish, providing a technical drive that keeps you alert through the heart of the state.
63% highway — fuel and pacing are the main things to plan.
29 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88.4 mi on Lance Corporal Roy M Wheat Memorial Highway.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Lance Corporal Roy M Wheat Memorial Highway and US 45. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 263.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Starkville, MS, road signs point toward Jackson, Laurel, Tuscaloosa and Tupelo.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Starkville is a city in East Mississippi. Mississippi State University is located just to the east of the city limits, and is included in this article.
Doable as a same-day drive at 5h 8m. Total distance: 263.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 8m drive, comfortable solo distance.
Frequently Asked Questions
The longest stretch is about 88.4 miles on Lance Corporal Roy M Wheat Memorial Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Starkville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Not recommended in a single day. At 5.1 hours each way, a round trip means 10.3 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Starkville, MS before the return drive.
