Parking area
0.1 mi from route
Trip from Biloxi, MS to Nettleton, MS
Pin this tripCompiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Oct 18, 2026 · Editorial standards
Drive Time
5h 52m
Distance
301.9 mi
486 km
Drive Score
10/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$46
one way
EV Charging
Unknown
Best Time to Leave
4 AM
5h 39m
★
6 AM
5h 52m
8 AM
6h 18m
10 AM
6h 1m
12 PM
5h 59m
3 PM
6h 3m
5 PM
6h 17m
8 PM
5h 44m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Biloxi, MS
Wikimedia Commons
Nettleton, MS
Efrem Efre
Trip Overview
Biloxi, MS to Nettleton, MS is 301.9 miles and takes about 5h 52m via Main Street, Division Street, and Bohn Street, with a fuel budget near $44 and enough daylight to finish in a day. This trip stays within Mississippi, traversing the Southeast region. Expect a drive primarily on surface roads, offering a more local feel compared to interstate travel. With just one recommended stop and a drive that can comfortably be completed in a single day, this route is ideal for those looking for a straightforward journey through the state.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
150.9 miles from Biloxi, MS
A natural place for your longest stop of the day , about 2h 54m into the drive .
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Lance Corporal Roy M Wheat Memorial Highway | 88.4 mi | 1h 35m |
| US 45 | 68.8 mi | 1h 19m |
| US Highway 45 Alternate | 53 mi | 1h 3m |
| US 49 | 42.2 mi | 49m |
| MS 15 | 20.7 mi | 24m |
| Martin Luther King Drive | 9.8 mi | 11m |
| I 59 | 9 mi | 10m |
| US 98 | 3.3 mi | 4m |
Longest stretch:
Lance Corporal Roy M Wheat Memorial Highway
— 88.4 mi, about 1h 35m
Traffic on I-59
Hour-of-day weekday pattern from 24 FHWA count stations on your route.
Peak
4 PM
~969 veh/hr typical · worst 1,202
Quietest
1 AM
~89 veh/hr
Peak-to-quiet ratio
10.9×
busier at peak than in the quiet hours
12a
6a
noon
6p
11p
Averaged across 103 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Nettleton, MS.
1
Start on Howard Avenue
91 ft
·
6 sec
·
Howard Avenue
2
Turn right onto Main Street
0.5 mi
·
1 min
·
Main Street
3
Turn left onto Division Street
0.5 mi
·
1 min
·
Division Street
4
Take the ramp onto Bohn Street
139 ft
·
3 sec
·
Bohn Street
5
Turn straight
0.3 mi
·
37 sec
6
Merge onto I 110
3.1 mi
·
4 min
·
I 110
7
Continue on MS 15; MS 67
21 mi
·
24 min
·
MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi
·
47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi
·
46 min
·
US 49
Use the straight lane.
10
Continue on US 49
2.4 mi
·
2 min
·
US 49
Use the straight / slight right lanes.
11
Take the exit
0.3 mi
·
51 sec
12
Merge onto US 98
2.5 mi
·
2 min
·
US 98
Use the straight / slight right lanes.
13
Take the exit onto US 98
0.8 mi
·
1 min
·
US 98
Toward I 59 North, US 98 West: Columbia, Laurel
Use the straight / slight right lanes.
14
Merge onto I 59; US 98
88 mi
·
1 hr 35 min
·
Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
15
Keep slight right at fork onto I 59
9.0 mi
·
10 min
·
I 59
Toward I 59 North, I 20 East: Meridian, Tuscaloosa
Use the straight lane.
16
Take the exit
0.3 mi
·
47 sec
Toward US 45 North: Macon
Use the slight right lane.
17
Merge onto US 45
65 mi
·
1 hr 14 min
·
US 45
Use the straight lane.
18
Keep slight left at fork onto US 45 ALT
53 mi
·
1 hr 3 min
·
US Highway 45 Alternate
Toward US 45 Alternate North: West Point, Tupelo
Use the straight / slight left lanes.
19
Continue on US 45 ALT
9.8 mi
·
11 min
·
Martin Luther King Drive
20
Take the exit
0.2 mi
·
33 sec
Toward US 45 South, MS 145 North: Shannon, Nettleton
21
Turn right onto US 45; US 278
3.7 mi
·
4 min
·
US 45; US 278
22
Turn left onto MS 145
1.0 mi
·
1 min
·
Will Robbins Highway
23
Turn slight left onto Main Street
0.2 mi
·
21 sec
·
Main Street
24
Arrive at destination
Main Street
Trip Plan
Given the 5-hour 52-minute duration, you can easily complete this trip in one day. Aim for an early morning departure from Biloxi to maximize daylight and avoid any potential afternoon traffic. With only one recommended stop, plan your breaks strategically along the route, perhaps around the halfway point or when you feel the need for a stretch. The $44 fuel cost is an estimate, so keep an eye on your fuel gauge, especially since you'll be on surface roads for the entire 301.9 miles. Familiarize yourself with the primary roads, Main Street, Division Street, and Bohn Street, before you leave to ensure a smooth drive.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 150.9 miles from Biloxi, MS, or about 2h 54m into the drive.
The longest continuous stretch on this route runs about 88.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 66 miles or 1h 20m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 150.9 miles or 2h 54m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 45m
Traffic, exits, and arrival timing usually matter more near Nettleton, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 301.9 miles and 5h 52m.
Your first comfortable stop window is around 66 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Lance Corporal Roy M Wheat Memorial Highway for about 88.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Mid-route town
Meal stop
151 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 66 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 150.9 miles from Biloxi, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Lance Corporal Roy M Wheat Memorial Highway if your tank is already low. That segment runs about 88.4 miles.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Stops Along Your Drive
Picked by where they fit in your drive — first break, midpoint reset, final stretch.
Parking Area
0.1 mi from route
Dizzy Dean Rest Area
0.1 mi from route
Service Plaza
0.1 mi from route
Love's Travel Stop
0.1 mi from route
Love's Travel Stop
0.1 mi from route
Pilot Travel Center
0.2 mi from route
Mr. Fuel Travel Center
1.6 mi from route
Love's Travel Stop
1.9 mi from route
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 165 decision points cluster between mile 25.1 and 234 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip
|
~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
7
70.4 mi into trip
|
~1h 26m in
|
US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
159.6 mi into trip
|
~3h 3m in
|
I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
6
168.6 mi into trip
|
~3h 14m in
Take the exit toward US 45 North: Macon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Toward US 45 North: Macon
8
234 mi into trip
|
~4h 29m in
|
US 45 ALT / US Highway 45 Alternate
Keep slight left at fork onto US 45 ALT / US Highway 45 Alternate toward US 45 Alternate North: West Point, Tupelo
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Toward US 45 Alternate North: West Point, Tupel...
Fuel & Cost
Regular Gas
$46.35 one way
$92.71 round trip
$3.90/gal
25.4 MPG avg
106 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $51.80 | $103.60 |
| premium | $4.75 | $56.47 | $112.94 |
| diesel | $5.88 | $69.94 | $139.87 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$46
Meals
$25–$50
Total
$71–$96
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 105.6 kg one way.
Driving Electric?
About $32 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 90.6 | 1 | $31.70 | $14.49 |
| Efficient EV | 75.5 | 0 | $26.42 | $12.08 |
| EV Truck/SUV | 120.8 | 1 | $42.27 | $19.32 |
Gas CO2
106 kg
EV CO2
35 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Origin
Biloxi, MS
Evening in Biloxi on Sunday
Local time
6:59 PM
CDT
Current temp
53°F
Clear
NE 15 mph
0% chance
Live forecast
Destination
Nettleton, MS
Evening in Nettleton on Sunday
Local time
6:59 PM
CDT
Current temp
41°F
Clear
NNE 5 mph
0% chance
Live forecast
49°F
Meridian, MS
151 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
12 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 52m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
13 mi from route
~33 min detour
Free
near mile 301.9
View on nps.gov
Natchez Trace National Scenic Trail
National Scenic Trail
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
17 mi from route
~44 min detour
Free
near mile 301.9
View on nps.gov
Park data from the National Park Service API. Alerts update every 2 hours.
What kind of drive is this?
This route is entirely on surface roads, with 0% highway share. You'll be navigating local streets like Main Street, Division Street, and Bohn Street for the entire 301.9 miles. Since there's no highway portion, anticipate a consistent pace without the rapid acceleration and deceleration often found on interstates. The longest stretch of uninterrupted driving isn't specified, but the absence of highway means you'll likely encounter more intersections and varied speed limits throughout the 5-hour drive.
66% highway — fuel and pacing are the main things to plan.
24 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88.4 mi on Lance Corporal Roy M Wheat Memorial Highway.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Lance Corporal Roy M Wheat Memorial Highway and US 45. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort
10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 16 significant decision points across 301.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
427 ft
20 ft
Total Climb
716 ft
Total Descent
476 ft
Highest Point
427 ft
~129.4 mi in
Elevation Range
407 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Nettleton, MS, road signs point toward Jackson, Laurel, Tuscaloosa and Tupelo.
Jackson
25.1 mi in
|
~32m
Laurel
70.4 mi in
|
~1h 26m
|
via US 98
Tuscaloosa
159.6 mi in
|
~3h 3m
|
via I 59
Tupelo
234 mi in
|
~4h 29m
|
via US 45 ALT
About the Cities
Starting in Biloxi, MS
Full guide →Founded 1720
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Top landmarks
- • Jefferson Davis Presidential Library and Museum — presidential library and museum for Confederate States President Jefferson Davis...
- • Beauvoir — post-war home of the former President of the Confederate States of America, Jeff...
- • Biloxi Light — lighthouse in Mississippi, United States
Arriving in Nettleton, MS
Full guide →City content from Wikivoyage (CC BY-SA 4.0) and Wikidata (CC0).
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 52m. Total distance: 301.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 52m drive, comfortable solo distance.
Frequently Asked Questions
The longest stretch is about 88.4 miles on Lance Corporal Roy M Wheat Memorial Highway. The full list of main roads is in the Roads section above.
Yes — we found about 9 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Nettleton, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 9 rest areas along the route for bathroom stops.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Tupelo National Battlefield and Natchez Trace National Scenic Trail. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.9 hours each way, a round trip means 11.7 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Nettleton, MS before the return drive.
How this page is built
Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, USGS 3DEP for elevation, NPS for national parks, and FHWA TMAS for hourly traffic volumes. See our methodology for refresh cadence and limitations.
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