Gulfport to Nettleton is 296.8 miles and takes about 5h 46m via Lance Corporal Roy M Wheat Memorial Highway and US 45, with a fuel budget near $41 and enough daylight to finish in a day. This drive stays within Mississippi, moving from the Southeast region up into the same region. It's a single-day trip that offers a mix of highway cruising and surface roads. Plan for a straightforward drive that covers a good portion of the state.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
148.4 miles from Gulfport, MS
A natural place for your longest stop of the day
, about 2h 51m into the drive
.
Main Roads
Road
Distance
Duration
Lance Corporal Roy M Wheat Memorial Highway
88.4 mi
1h 35m
US 45
68.8 mi
1h 19m
25th Avenue
60.1 mi
1h 14m
US Highway 45 Alternate
53 mi
1h 3m
Martin Luther King Drive
9.8 mi
11m
I 59
9 mi
10m
US 98
3.3 mi
4m
US 49
2.4 mi
2m
Longest stretch:
Lance Corporal Roy M Wheat Memorial Highway
— 88.4 mi, about 1h 35m
Traffic on I-59
Hour-of-day weekday pattern from 24 FHWA count stations on your route.
Peak
4 PM
~969 veh/hr typical
· worst 1,202
Quietest
1 AM
~89 veh/hr
Peak-to-quiet ratio
10.9×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 103 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Gulfport, MS and Nettleton, MS.
1
Start on US 49
60 mi·1 hr 14 min·25th Avenue
Use the straight lane.
2
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
3
Take the exit
0.3 mi·51 sec
4
Merge onto US 98
2.5 mi·2 min·US 98
Use the straight / slight right lanes.
5
Take the exit onto US 98
0.8 mi·1 min·US 98
Toward I 59 North, US 98 West: Columbia, LaurelUse the straight / slight right lanes.
6
Merge onto I 59; US 98
88 mi·1 hr 35 min·Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
7
Keep slight right at fork onto I 59
9.0 mi·10 min·I 59
Toward I 59 North, I 20 East: Meridian, TuscaloosaUse the straight lane.
8
Take the exit
0.3 mi·47 sec
Toward US 45 North: MaconUse the slight right lane.
9
Merge onto US 45
65 mi·1 hr 14 min·US 45
Use the straight lane.
10
Keep slight left at fork onto US 45 ALT
53 mi·1 hr 3 min·US Highway 45 Alternate
Toward US 45 Alternate North: West Point, TupeloUse the straight / slight left lanes.
11
Continue on US 45 ALT
9.8 mi·11 min·Martin Luther King Drive
12
Take the exit
0.2 mi·33 sec
Toward US 45 South, MS 145 North: Shannon, Nettleton
13
Turn right onto US 45; US 278
3.7 mi·4 min·US 45; US 278
14
Turn left onto MS 145
1.0 mi·1 min·Will Robbins Highway
15
Turn slight left onto Main Street
0.2 mi·21 sec·Main Street
16
Arrive at destination
Main Street
Trip Plan
Given the 5h 46m estimated drive time, this trip is easily manageable in a single day. Leaving in the morning will give you plenty of time to reach Nettleton before dark. The route includes one recommended stop, so consider breaking up the drive around the halfway point to stretch your legs. Keep an eye on your fuel gauge, especially during the longer highway segments, as the estimated cost is $41. The transition from highway to surface roads around mile 136 (based on the highway share) is a good point to be mindful of your surroundings and any potential changes in speed limits.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 148.4 miles from Gulfport, MS, or about 2h 51m into the drive.
The longest continuous stretch on this route runs about 88.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 65 miles or 1h 20m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 148.4 miles or 2h 51m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 41m
Traffic, exits, and arrival timing usually matter more near Nettleton, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Gulfport, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Gulfport, MS
This is one driving day of about 296.8 miles and 5h 46m.
Your first comfortable stop window is around 65 miles from Gulfport, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Lance Corporal Roy M Wheat Memorial Highway for about 88.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 10
5 decision points cluster between mile 62.9 and 228.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
62.9 mi into trip|~1h 18m in|US 98
Merge onto US 98
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
7
65.3 mi into trip|~1h 20m in|US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
154.5 mi into trip|~2h 58m in|I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
6
163.5 mi into trip|~3h 8m in
Take the exit toward US 45 North: Macon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Toward US 45 North: Macon
8
228.8 mi into trip|~4h 23m in|US 45 ALT / US Highway 45 Alternate
Keep slight left at fork onto US 45 ALT / US Highway 45 Alternate toward US 45 Alternate North: West Point, Tupelo
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Toward US 45 Alternate North: West Point, Tupel...
Fuel & Cost
Regular Gas
$43.48 one way
$86.96 round trip
$3.72/gal25.4 MPG avg104 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.13
$48.27
$96.54
premium
$4.49
$52.42
$104.84
diesel
$5.60
$65.42
$130.85
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$43
Meals
$25–$50
Total
$68–$93
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 103.8 kg one way.
Prices: EIA weekly data, 2026-08-31.
Driving Electric?
About $31 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
89
1
$31.16
$14.25
Efficient EV
74.2
0
$25.97
$11.87
EV Truck/SUV
118.7
1
$41.55
$19.00
Gas CO2
104 kg
EV CO2
35 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Sep 4, 2026
Origin
Gulfport, MS
Night
in Gulfport on Saturday
Local time
11:19 PM
CDT
Current temp
86°F
Showers And Thunderstorms
NE 5 mph80% chanceLive forecast
Special Weather Statement
Special Weather Statement issued September 4 at 11:51AM CDT by NWS Mobile AL
Flash Flood Warning
Flash Flood Warning issued September 4 at 11:41AM CDT until September 4 at 1:45PM CDT by NWS New Orleans LA
Destination
Nettleton, MS
Night
in Nettleton on Saturday
Local time
11:19 PM
CDT
Current temp
99°F
Slight Chance Showers And Thunderstorms
ESE 0 to 5 mph20% chanceLive forecast
Special Weather Statement
Special Weather Statement issued September 4 at 11:51AM CDT by NWS Mobile AL
Flash Flood Warning
Flash Flood Warning issued September 4 at 11:41AM CDT until September 4 at 1:45PM CDT by NWS New Orleans LA
73°F
Quitman, MS
148 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
13 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 46m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
13 mi from route
~33 min detour
Free
near mile 296.8
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
17 mi from route
~44 min detour
Free
near mile 296.8
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
About 46% of this 296.8-mile route is on highways. You'll encounter an 88.4-mile stretch on Lance Corporal Roy M Wheat Memorial Highway before transitioning to surface roads. Expect a blend of faster-paced highway driving and more local cruising as you navigate through Mississippi.
46% highway, the rest on surface roads — varied driving throughout.
16 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88.4 mi on Lance Corporal Roy M Wheat Memorial Highway.
How Hard Is This Drive?
8/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 62.9 miles in near US 98.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 10 significant decision points across 296.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 62.9 miles (US 98): Merge point - match speed before joining. Lane positioning matters here; at 65.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 154.5 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
462 ft20 ft
Total Climb
619 ft
Total Descent
339 ft
Highest Point
462 ft
~148.4 mi in
Elevation Range
442 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Gulfport, MS and Nettleton, MS, road signs point toward Laurel, Tuscaloosa and Tupelo.
Doable as a same-day drive at 5h 46m. Total distance: 296.8 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 46m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 88.4 miles on Lance Corporal Roy M Wheat Memorial Highway. The full list of main roads is in the Roads section above.
Yes — we found about 8 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Nettleton, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 8 rest areas along the route for bathroom stops.
The main spots that need attention: at 62.9 miles (US 98): Merge point - match speed before joining. Lane positioning matters here; at 65.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 154.5 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Tupelo National Battlefield and Natchez Trace National Scenic Trail. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.8 hours each way, a round trip means 11.6 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Nettleton, MS before the return drive.
