East Independence, MO to Houston, MO is 254.6 miles and takes about 5h 6m via US 63, with a fuel budget near $40 and enough daylight to finish in a day. This trip stays within the Midwest, offering a straightforward drive from one Missouri locale to another. You'll primarily be on US 63 for much of the journey, making it a relatively easy route to navigate. With a recommended one-day drive, this route is ideal if you're looking for a direct connection between these two points without extensive planning.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
127.3 miles from East Independence, MO
A natural place for your longest stop of the day
, about 2h 24m into the drive
.
Main Roads
Road
Distance
Duration
US 63
73.5 mi
1h 29m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Dwight D. Eisenhower Highway
54.3 mi
58m
North Bishop Avenue
47.4 mi
58m
MO A
7.5 mi
10m
MO E
7.5 mi
10m
South Little Blue Parkway
1.7 mi
3m
Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
1m
Longest stretch:
US 63
— 73.5 mi, about 1h 29m
Turn-by-Turn Driving Directions
Step-by-step road directions between East Independence, MO and Houston, MO.
1
Start on East 9th Street South
79 ft·8 sec·East 9th Street South
2
Turn left onto Main Road
0.3 mi·1 min·Main Road
3
Turn left onto East Truman Road
0.7 mi·1 min·East Truman Road
4
Turn right onto Holke Road
0.9 mi·1 min·Holke Road
5
Turn straight onto South Jackson Drive
1.2 mi·2 min·South Jackson Drive
6
Turn left onto East R.D. Mize Road
0.2 mi·37 sec·East R.D. Mize Road
7
Turn right onto South Little Blue Parkway
1.7 mi·3 min·South Little Blue Parkway
8
Take the ramp
0.3 mi·38 sec
Exit 17Toward Little Blue Parkway, 39th Street, Mall EntranceUse the left lane.
9
Continue on I 70
53 mi·56 min·Dwight D. Eisenhower Highway
10
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.5 mi·1 min·Sheriff Roger I. Wilson Memorial Highway
15
Take the exit
0.1 mi·15 sec
Exit 128AToward US 63: Jefferson City, Moberly
16
Turn slight right
192 ft·4 sec
Toward US 63 South: Jefferson City
17
Merge onto US 63 Conn
521 ft·11 sec·US 63 Conn
Use the slight right lane.
18
Take the exit
0.4 mi·49 sec
Toward US 63 South: Jefferson CityUse the straight lane.
19
Merge onto US 63
27 mi·29 min·US 63
20
Take the exit onto US 63
1.5 mi·2 min·US 63
Toward US 54 West, US 63 South: Jefferson City
21
Take the exit onto US 63
217 ft·4 sec·US 63
Toward US 63 South, US 50
22
Keep slight left at fork onto US 63
0.1 mi·16 sec·US 63
Toward US 63 South, US 50
23
Keep slight left at fork onto US 63
0.1 mi·15 sec·US 63
Toward US 63 South, US 50 EastUse the slight left lane.
24
Keep slight left at fork onto US 63
12 mi·14 min·US 63
25
Keep slight right at fork onto US 63
33 mi·43 min·US 63
Toward US 63 South: Rolla
26
Turn right onto MO A
7.5 mi·10 min·MO A
27
Turn straight onto MO E
7.5 mi·10 min·MO E
28
Enter roundabout onto MO E
62 ft·1 sec·Tim Bradley Way
29
Continue on MO E
0.4 mi·48 sec·Tim Bradley Way
Use the left lane.
30
Turn slight right onto I 44 Business; US Historic 66; US 63
30 ft·0 sec·North Bishop Avenue
31
Keep slight right at fork onto I 44 Business; US Historic 66; US 63
145 ft·2 sec·North Bishop Avenue
32
Continue on I 44 Business; US Historic 66; US 63
47 mi·58 min·North Bishop Avenue
Use the left / straight lanes.
33
Turn right onto MO F
0.3 mi·45 sec·East Walnut Street
34
Turn left onto North 2nd Street
0.1 mi·32 sec·North 2nd Street
35
Turn right
176 ft·7 sec
36
Arrive at destination
Trip Plan
Given the 5-hour duration, starting your drive in the morning from East Independence, MO, will allow you to reach Houston, MO, with plenty of daylight to spare. Since this is a one-day trip, you have flexibility, but consider breaking it up with a brief stop around the halfway point if needed. Keep an eye on your fuel, especially during the 73.5-mile stretch on US 63, as services might be less frequent. The fuel cost is estimated at $40, so budget accordingly.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 127.3 miles from East Independence, MO, or about 2h 24m into the drive.
The longest continuous stretch on this route runs about 73.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 56 miles or 1h 6m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 127.3 miles or 2h 24m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 8m
Traffic, exits, and arrival timing usually matter more near Houston, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving East Independence, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from East Independence, MO
This is one driving day of about 254.6 miles and 5h 6m.
Your first comfortable stop window is around 56 miles from East Independence, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 63 for about 73.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 25
5 decision points cluster between mile 5 and 146.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
5 mi into trip|~10m in
Take the ramp toward Little Blue Parkway, 39th Street, Mall Entrance
Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Exit 17
Toward Little Blue Parkway, 39th Street, Mall E...
6
117.1 mi into trip|~2h 12m in
Take the exit toward US 63: Jefferson City, Moberly
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 128A
Toward US 63: Jefferson City, Moberly
7
117.3 mi into trip|~2h 13m in|US 63 Conn
Merge onto US 63 Conn
Merge point - match speed before joining. Lane positioning matters here
Use the slight right lane.
7
146.5 mi into trip|~2h 45m in|US 63
Keep slight left at fork onto US 63 toward US 63 South, US 50
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 63 South, US 50
9
146.6 mi into trip|~2h 45m in|US 63
Keep slight left at fork onto US 63 toward US 63 South, US 50 East
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward US 63 South, US 50 East
Fuel & Cost
Regular Gas
$39.80 one way
$79.61 round trip
$3.97/gal25.4 MPG avg89 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$43.70
$87.41
premium
$4.89
$49.00
$97.99
diesel
$5.61
$56.21
$112.42
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$40
Meals
$25–$50
Total
$65–$90
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 89.1 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $27 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
76.4
0
$26.73
$12.22
Efficient EV
63.7
0
$22.28
$10.18
EV Truck/SUV
101.8
1
$35.64
$16.29
Gas CO2
89 kg
EV CO2
30 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 18, 2026
Origin
East Independence, MO
Night
in East Independence on Saturday
Local time
9:46 PM
CDT
Current temp
58°F
Sunny
NW 10 to 14 mph6% chanceLive forecast
Destination
Houston, MO
Night
in Houston on Saturday
Local time
9:46 PM
CDT
Current temp
54°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
4 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 6m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This drive is a mixed bag, with about 30% of the route utilizing highways. You'll encounter the U.S. Submarine Veterans' Memorial Highway and the Dwight D. Eisenhower Highway for some stretches, offering a faster pace. However, expect to transition to US 63, which can feel more like a traditional two-lane highway at times. The longest uninterrupted stretch you'll experience is 73.5 miles on US 63, so be prepared for varying road conditions and speeds as you travel south.
30% highway, the rest on surface roads — varied driving throughout.
36 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 73.5 mi on US 63.
How Hard Is This Drive?
9/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 5 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 25 significant decision points across 254.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 117.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 117.3 miles (US 63 Conn): Merge point - match speed before joining. Lane positioning matters here.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from East Independence, MO to Houston, MO, road signs begin pointing toward Moberly along the way.
Moberly
117.1 mi in|~2h 12m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 6m. Total distance: 254.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 6m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile.
Frequently Asked Questions
The longest stretch is about 73.5 miles on US 63. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Houston, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 117.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 117.3 miles (US 63 Conn): Merge point - match speed before joining. Lane positioning matters here.
Not recommended in a single day. At 5.1 hours each way, a round trip means 10.2 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Houston, MO before the return drive.
