Des Peres, MO to East Independence, MO is 227.8 miles and takes about 4h 25m via Dwight D Eisenhower Highway, with a fuel budget near $36 and enough daylight to finish in a day. This trip keeps you within the Midwest region, traveling entirely within Missouri. Expect a driving experience characterized by frequent turns and local road segments, rather than a straight, high-speed interstate journey. With a recommended one-day drive, you have the flexibility to depart at your leisure and enjoy the progression across the state.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
113.9 miles from Des Peres, MO
A natural place for your longest stop of the day
, about 2h 17m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D Eisenhower Highway
80.7 mi
1h 35m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Dwight D. Eisenhower Highway
54.3 mi
58m
Avenue of the Saints
25.4 mi
30m
Sheriff Roger I. Wilson Memorial Highway
2 mi
2m
I 270
1.9 mi
2m
South Little Blue Parkway
1.6 mi
3m
Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
1m
Longest stretch:
Dwight D Eisenhower Highway
— 80.7 mi, about 1h 35m
Turn-by-Turn Driving Directions
Step-by-step road directions between Des Peres, MO and East Independence, MO.
1
Start on MO 100
0.9 mi·1 min·Manchester Road
2
Take the ramp
0.2 mi·14 sec
Toward I 270 North
3
Merge onto I 270
1.9 mi·2 min·I 270
4
Take the exit
0.1 mi·17 sec
Exit 12Toward I 64, US 40, US 61: Wentzville, Saint LouisUse the slight right lane.
5
Keep slight left at fork
0.4 mi·48 sec
Toward I 64 West, US 40 West, US 61 North: WentzvilleUse the slight left lane.
6
Continue on this road
0.1 mi·9 sec·this road
Exit 12Toward I 64 West, US 40 West, US 61 North: Wentzville
7
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight lane.
8
Take the exit onto US 40
0.6 mi·1 min·US 40
Exit 1AToward I 70 West, US 40 West: Kansas CityUse the straight / slight left lanes.
9
Merge onto I 70; US 40
81 mi·1 hr 35 min·Dwight D Eisenhower Highway
10
Continue on I 70; US 40
2.0 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
11
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
54 mi·58 min·U.S. Submarine Veterans' Memorial Highway
14
Continue on I 70; US 40
52 mi·56 min·Dwight D. Eisenhower Highway
15
Take the exit
0.3 mi·40 sec
Exit 17Toward Little Blue Parkway, 39th Street, Mall EntranceUse the slight right lane.
16
Turn right onto South Little Blue Parkway
1.6 mi·3 min·South Little Blue Parkway
17
Turn left onto East R.D. Mize Road
0.2 mi·37 sec·East R.D. Mize Road
18
Turn right onto South Jackson Drive
1.2 mi·2 min·South Jackson Drive
19
Turn straight onto Holke Road
0.9 mi·2 min·Holke Road
20
Turn left onto East Truman Road
0.7 mi·1 min·East Truman Road
21
Turn right onto Main Road
0.3 mi·1 min·Main Road
22
Turn right onto East 9th Street South
79 ft·3 sec·East 9th Street South
23
Arrive at destination
East 9th Street South
Trip Plan
Given this is a single-day drive of under five hours, you have a lot of flexibility with your departure time. Consider leaving in the morning to allow for potential delays or spontaneous stops. The route involves frequent turns, so pay close attention to your navigation, especially as you approach East Independence. With only one stop recommended, you can plan your fuel and rest breaks strategically, perhaps around the halfway point or when you feel the need to stretch your legs. Keep an eye on your fuel gauge, as the $36 budget is an estimate and local prices can vary.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 113.9 miles from Des Peres, MO, or about 2h 17m into the drive.
The longest continuous stretch on this route runs about 80.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 50 miles or 1h 1m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 113.9 miles or 2h 17m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 35m
Traffic, exits, and arrival timing usually matter more near East Independence, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Des Peres, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Des Peres, MO
This is one driving day of about 227.8 miles and 4h 25m.
Your first comfortable stop window is around 50 miles from Des Peres, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D Eisenhower Highway for about 80.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 3.1 and 222.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
3.1 mi into trip|~4m in
Take the exit toward I 64, US 40, US 61: Wentzville, Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 12
Toward I 64, US 40, US 61: Wentzville, Saint Lo...
8
3.2 mi into trip|~4m in
Keep slight left at fork toward I 64 West, US 40 West, US 61 North: Wentzville
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 64 West, US 40 West, US 61 North: Went...
5
3.7 mi into trip|~5m in|I 64; US 40; US 61 / Avenue of the Saints
Merge onto I 64; US 40; US 61 / Avenue of the Saints
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
8
29.1 mi into trip|~36m in|US 40
Take the exit onto US 40 toward I 70 West, US 40 West: Kansas City
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Exit 1A
Toward I 70 West, US 40 West: Kansas City
8
222.6 mi into trip|~4h 14m in
Take the exit toward Little Blue Parkway, 39th Street, Mall Entrance
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 17
Toward Little Blue Parkway, 39th Street, Mall E...
Fuel & Cost
Regular Gas
$35.61 one way
$71.23 round trip
$3.97/gal25.4 MPG avg80 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$39.10
$78.21
premium
$4.89
$43.84
$87.68
diesel
$5.61
$50.30
$100.59
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$36
Meals
$25–$50
Total
$61–$86
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 79.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $24 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
68.3
0
$23.92
$10.93
Efficient EV
57
0
$19.93
$9.11
EV Truck/SUV
91.1
1
$31.89
$14.58
Gas CO2
80 kg
EV CO2
27 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Des Peres, MO
Late night
in Des Peres on Tuesday
Local time
3:52 AM
CDT
Current temp
71°F
Unavailable
Live forecast
Destination
East Independence, MO
Late night
in East Independence on Tuesday
Local time
3:52 AM
CDT
Current temp
64°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
7 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 25m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route presents a turn-heavy local drive profile, with a highway share of only 2. This means you'll be navigating a variety of road types, moving between faster highway stretches and more deliberate local road sections. The longest uninterrupted stretch you'll encounter is 80.7 miles on the Dwight D Eisenhower Highway. Be prepared for a dynamic driving experience where the pace can shift as you transition between these different road environments.
Only 2% highway — the rest is turn-by-turn surface driving.
23 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80.7 mi on Dwight D Eisenhower Highway.
How Hard Is This Drive?
6/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 15 points where you need to pay attention to lane position or signs. The trickiest moment comes around 3.1 miles in.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 227.8 miles you will encounter 15 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 3.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 3.2 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 3.7 miles (I 64; US 40; US 61 / Avenue of the Saints): Merge point - match speed before joining. Lane positioning matters here.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 25m. Total distance: 227.8 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 25m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 80.7 miles on Dwight D Eisenhower Highway. The full list of main roads is in the Roads section above.
Yes — we found about 30 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at East Independence, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 30 rest areas along the route for bathroom stops.
The main spots that need attention: at 3.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 3.2 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 3.7 miles (I 64; US 40; US 61 / Avenue of the Saints): Merge point - match speed before joining. Lane positioning matters here.
Yes — Gateway Arch National Park. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.4 hours each way, an in-and-out day trip would put you behind the wheel for 8.8 hours — manageable with a long break at East Independence, MO, but most travelers stay overnight.
