Biloxi, MS to Walnut Grove, MS is 312.9 miles and takes about 6h 52m via US 49 and US 49W, with a fuel budget near $47 and enough daylight to finish in a day. This trip stays within Mississippi, traversing the Southeast region. It's primarily a highway drive, so expect a steady pace for most of the journey. With a recommended one-day drive time, it's a straightforward option for connecting these two points.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
156.4 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 3h 14m into the drive
.
Main Roads
Road
Distance
Duration
US 49
140.6 mi
2h 53m
US 49W
46.7 mi
56m
Medgar Evers Boulevard
39.5 mi
48m
South Highway 61
34.8 mi
44m
MS 15
20.7 mi
24m
North Sunflower Avenue
13.5 mi
23m
I 20
4.3 mi
5m
I 110
3.1 mi
4m
Longest stretch:
US 49
— 140.6 mi, about 2h 53m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Walnut Grove, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
17
Take the exit onto US 49
0.2 mi·21 sec·US 49
18
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
19
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
20
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
21
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
22
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
23
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
24
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
25
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
26
Turn left onto US 82
0.7 mi·1 min·US 82
27
Turn right onto MS 448
13 mi·23 min·North Sunflower Avenue
28
Turn left onto MS 448
1.1 mi·2 min·MS 448
29
Turn right onto US 61; US 278
35 mi·44 min·South Highway 61
30
Turn left onto MS 802
0.8 mi·3 min·Lake Street
31
Continue on Butler Street
0.1 mi·25 sec·Butler Street
32
Continue on Jenkins Street
0.4 mi·1 min·Jenkins Street
33
Continue on North New Africa Road
0.3 mi·1 min·North New Africa Road
34
Turn left onto Buzzard Roost Road
1.0 mi·4 min·Buzzard Roost Road
35
Turn right onto Rena Lara Road
1.5 mi·5 min·Rena Lara Road
36
Continue on Alligator - Rena Lara Road
1.3 mi·5 min·Alligator - Rena Lara Road
37
Continue on this road
0.2 mi·53 sec·this road
38
Continue on Alligator - Rena Lara Road
0.3 mi·1 min·Alligator - Rena Lara Road
39
Arrive at destination
Trip Plan
Given the 6-hour-plus drive time, departing early in the morning is advisable to maximize daylight and allow for a comfortable pace. The route has only one recommended stop, so plan your breaks strategically. Keep an eye on your fuel gauge, especially during the 140.6-mile stretch on US 49, as services might be less frequent. The $47 fuel cost estimate should help you budget for this leg of your travel within Mississippi.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 156.4 miles from Biloxi, MS, or about 3h 14m into the drive.
The longest continuous stretch on this route runs about 140.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 69 miles or 1h 24m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 156.4 miles or 3h 14m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 17m
Traffic, exits, and arrival timing usually matter more near Walnut Grove, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 312.9 miles and 6h 52m.
Your first comfortable stop window is around 69 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 140.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 21
5 decision points cluster between mile 25.1 and 164.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
158.9 mi into trip|~3h 17m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
6
162.2 mi into trip|~3h 21m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
5
164.9 mi into trip|~3h 25m in|US 49
Take the exit onto US 49 toward I 220 North, I 49 North: North Jackson, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 220 North, I 49 North: North Jackson,...
Fuel & Cost
Regular Gas
$47.26 one way
$94.51 round trip
$3.84/gal25.4 MPG avg110 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$51.87
$103.75
premium
$4.56
$56.16
$112.32
diesel
$5.61
$69.08
$138.17
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$47
Meals
$25–$50
Total
$72–$97
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 109.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
17 DC fast chargers
· Coverage: excellent
North Bus Barn
Jackson, MS
NOODOE
14 DCFC
Lakeview Village Shopping Mall - Tesla Supercharger
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $33 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
93.9
1
$32.85
$15.02
Efficient EV
78.2
0
$27.38
$12.52
EV Truck/SUV
125.2
1
$43.81
$20.03
Gas CO2
109 kg
EV CO2
37 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Biloxi, MS
Night
in Biloxi on Saturday
Local time
11:48 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Walnut Grove, MS
Night
in Walnut Grove on Saturday
Local time
11:48 PM
CDT
Current temp
56°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 52m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~10 min detour
Free
near mile 172.6
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
22 mi from route
~55 min detour
Free
near mile 302.1
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is predominantly highway driving, with 81% of the trip on major roads. You'll experience a longest stretch of 140.6 miles on US 49, indicating a significant portion of uninterrupted travel. After this extended highway segment, you'll transition to surface roads, including Medgar Evers Boulevard, for the remainder of the trip. Expect a relatively consistent driving experience with fewer exits during the highway portions.
81% highway — fuel and pacing are the main things to plan.
39 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 140.6 mi on US 49.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 21 significant decision points across 312.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Walnut Grove, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Jackson
25.1 mi in|~32m
Yazoo City
162.2 mi in|~3h 21m|via I 20; US 49
Vicksburg
209.9 mi in|~4h 20m|via US 49W
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 52m. Total distance: 312.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 52m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 140.6 miles on US 49. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Walnut Grove, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Not recommended in a single day. At 6.9 hours each way, a round trip means 13.7 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Walnut Grove, MS before the return drive.
