This 317.1-mile drive from Biloxi, MS to Saltillo, MS is achievable in a single day, taking approximately 6 hours and 12 minutes of pure driving time. Primarily utilizing US 45 and US Highway 45 Alternate, with a significant portion on Lance Corporal Roy M Wheat Memorial Highway, this route focuses on highway travel. With an estimated fuel cost of $48, it's a budget-friendly journey. Given the duration, it's feasible as a day trip, though you might consider an early start to maximize daylight. This trip stays within the Southeast region, offering a consistent feel throughout your travels.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
158.6 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 3h 2m into the drive
.
Main Roads
Road
Distance
Duration
Lance Corporal Roy M Wheat Memorial Highway
88.4 mi
1h 35m
US 45
72.2 mi
1h 22m
US Highway 45 Alternate
53 mi
1h 3m
US 49
42.2 mi
49m
MS 15
20.7 mi
24m
Martin Luther King Drive
18.1 mi
20m
I 59
9 mi
10m
Martin Luther King, Junior Drive
3.3 mi
4m
Longest stretch:
Lance Corporal Roy M Wheat Memorial Highway
— 88.4 mi, about 1h 35m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Saltillo, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Take the exit
0.3 mi·51 sec
12
Merge onto US 98
2.5 mi·2 min·US 98
Use the straight / slight right lanes.
13
Take the exit onto US 98
0.8 mi·1 min·US 98
Toward I 59 North, US 98 West: Columbia, LaurelUse the straight / slight right lanes.
14
Merge onto I 59; US 98
88 mi·1 hr 35 min·Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
15
Keep slight right at fork onto I 59
9.0 mi·10 min·I 59
Toward I 59 North, I 20 East: Meridian, TuscaloosaUse the straight lane.
16
Take the exit
0.3 mi·47 sec
Toward US 45 North: MaconUse the slight right lane.
17
Merge onto US 45
65 mi·1 hr 14 min·US 45
Use the straight lane.
18
Keep slight left at fork onto US 45 ALT
53 mi·1 hr 3 min·US Highway 45 Alternate
Toward US 45 Alternate North: West Point, TupeloUse the straight / slight left lanes.
19
Continue on US 45 ALT
18 mi·20 min·Martin Luther King Drive
20
Continue on US 45; MS 6
3.3 mi·4 min·Martin Luther King, Junior Drive
Use the straight / slight right lanes.
21
Keep slight right at fork onto US 45
7.1 mi·8 min·US 45
Use the straight / slight left lanes.
22
Take the exit
0.3 mi·44 sec
23
Keep slight right at fork
341 ft·8 sec
24
Turn straight onto MS 145
0.2 mi·21 sec·MS 145
25
Turn slight right
453 ft·19 sec
26
Continue on this road
376 ft·19 sec·this road
27
Turn left onto Kyle Avenue
0.3 mi·1 min·Kyle Avenue
28
At end of road, turn left
0.5 mi·2 min
29
Continue on MS 363
500 ft·10 sec·East Mobile Street
30
Arrive at destination
MS 363
Trip Plan
To make the most of this 6-hour drive, consider departing Biloxi in the early morning to avoid potential traffic and maximize your time upon arrival in Saltillo. With only one recommended stop, you have flexibility in pacing. Plan for a refueling break before or during your longest stretch on Lance Corporal Roy M Wheat Memorial Highway, as services might be spaced out. Keep an eye on your fuel gauge, especially as you approach the 88.4-mile mark, to ensure a smooth continuation of your journey.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 158.6 miles from Biloxi, MS, or about 3h 2m into the drive.
The longest continuous stretch on this route runs about 88.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 70 miles or 1h 25m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 158.6 miles or 3h 2m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h
Traffic, exits, and arrival timing usually matter more near Saltillo, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 317.1 miles and 6h 12m.
Your first comfortable stop window is around 70 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Lance Corporal Roy M Wheat Memorial Highway for about 88.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 25.1 and 234 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
7
70.4 mi into trip|~1h 26m in|US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
159.6 mi into trip|~3h 3m in|I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
6
168.6 mi into trip|~3h 14m in
Take the exit toward US 45 North: Macon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Toward US 45 North: Macon
8
234 mi into trip|~4h 29m in|US 45 ALT / US Highway 45 Alternate
Keep slight left at fork onto US 45 ALT / US Highway 45 Alternate toward US 45 Alternate North: West Point, Tupelo
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Toward US 45 Alternate North: West Point, Tupel...
Fuel & Cost
Regular Gas
$47.89 one way
$95.78 round trip
$3.84/gal25.4 MPG avg111 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$52.57
$105.14
premium
$4.56
$56.92
$113.83
diesel
$5.61
$70.01
$140.02
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$48
Meals
$25–$50
Total
$73–$98
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 110.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $33 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
95.1
1
$33.30
$15.22
Efficient EV
79.3
0
$27.75
$12.68
EV Truck/SUV
126.8
1
$44.39
$20.29
Gas CO2
111 kg
EV CO2
37 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Biloxi, MS
Evening
in Biloxi on Saturday
Local time
8:25 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Saltillo, MS
Evening
in Saltillo on Saturday
Local time
8:25 PM
CDT
Current temp
77°F
Unavailable
Live forecast
79°F
Meridian, MS
159 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 12m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
3 mi from route
~6 min detour
Free
near mile 306.2
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
4 mi from route
~9 min detour
Free
near mile 317.1
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a highway-focused drive for this trip, with 64% of the route being on highways. You'll encounter an 88.4-mile stretch on Lance Corporal Roy M Wheat Memorial Highway, which is the longest uninterrupted segment. The road character is largely consistent, prioritizing efficient travel over winding scenic byways. While primarily highway, the inclusion of US 45 and its alternate suggests a mix of multi-lane sections and potentially some stretches that feel more like a primary artery than a high-speed interstate.
64% highway — fuel and pacing are the main things to plan.
30 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88.4 mi on Lance Corporal Roy M Wheat Memorial Highway.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Lance Corporal Roy M Wheat Memorial Highway and US 45. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 317.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Saltillo, MS, road signs point toward Jackson, Laurel, Tuscaloosa and Tupelo.
Jackson
25.1 mi in|~32m
Laurel
70.4 mi in|~1h 26m|via US 98
Tuscaloosa
159.6 mi in|~3h 3m|via I 59
Tupelo
234 mi in|~4h 29m|via US 45 ALT
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 12m. Total distance: 317.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 12m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 88.4 miles on Lance Corporal Roy M Wheat Memorial Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Saltillo, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Tupelo National Battlefield and Natchez Trace National Scenic Trail. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.2 hours each way, a round trip means 12.4 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Saltillo, MS before the return drive.
