Traveling from Biloxi to Pearl River covers 208 miles and typically takes about 4 hours and 16 minutes behind the wheel. Because this is a straightforward trek within Mississippi, you can easily complete the journey in a single day without needing an overnight stay. Expect to spend roughly $32 on fuel for the trip, making it a budget-friendly option for your itinerary. You will primarily navigate via the Lance Corporal Roy M Wheat Memorial Highway, US 49, and MS 19. It is a practical route for those looking to traverse the Southeast efficiently, though you should plan for at least one stop to keep the drive comfortable.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
104 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 2h 3m into the drive
.
Main Roads
Road
Distance
Duration
Lance Corporal Roy M Wheat Memorial Highway
88.4 mi
1h 35m
US 49
42.2 mi
49m
MS 19
36.7 mi
54m
MS 15
21.5 mi
25m
MS 16
4.9 mi
7m
US 98
3.3 mi
4m
I 110
3.1 mi
4m
I 59
2 mi
2m
Longest stretch:
Lance Corporal Roy M Wheat Memorial Highway
— 88.4 mi, about 1h 35m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Pearl River, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Take the exit
0.3 mi·51 sec
12
Merge onto US 98
2.5 mi·2 min·US 98
Use the straight / slight right lanes.
13
Take the exit onto US 98
0.8 mi·1 min·US 98
Toward I 59 North, US 98 West: Columbia, LaurelUse the straight / slight right lanes.
14
Merge onto I 59; US 98
88 mi·1 hr 35 min·Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
15
Keep slight right at fork onto I 59
2.0 mi·2 min·I 59
Toward I 59 North, I 20 East: Meridian, TuscaloosaUse the straight lane.
16
Take the exit
0.4 mi·44 sec
Toward South US 11, North Mississippi 19: Philadelphia, Meridian AirportUse the straight / slight right lanes.
17
Turn left onto US 11
1.2 mi·1 min·US 11
18
Turn left onto MS 19
37 mi·54 min·MS 19
19
At end of road, turn left onto MS 16; MS 19
2.0 mi·3 min·Beacon Street
20
Turn straight onto MS 15; MS 21
0.8 mi·1 min·MS 15; MS 21
21
Turn right onto MS 16
4.9 mi·7 min·MS 16
22
Turn right onto North Oswald Road
0.3 mi·1 min·North Oswald Road
23
Continue on Black Jack Road
0.1 mi·29 sec·Black Jack Road
24
Turn right onto High School Circle
59 ft·2 sec·High School Circle
25
Arrive at destination
High School Circle
Trip Plan
To make the most of your 4-hour and 16-minute drive, try to depart early in the morning to avoid peak traffic congestion on the busier stretches. Since the route includes one recommended stop, look for a convenient location around the midpoint to stretch your legs and refuel. Keep in mind that while the $32 fuel estimate provides a baseline, it is always wise to keep a little extra in your budget for fluctuating gas prices. Because this is a one-day trip, you have the flexibility to plan your stop based on your personal energy levels rather than a rigid schedule. Pay close attention to the transition points between the memorial highway and US 49 to ensure you stay on the correct path.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 104 miles from Biloxi, MS, or about 2h 3m into the drive.
The longest continuous stretch on this route runs about 88.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 46 miles or 57m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 104 miles or 2h 3m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 19m
Traffic, exits, and arrival timing usually matter more near Pearl River, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 208 miles and 4h 16m.
Your first comfortable stop window is around 46 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Lance Corporal Roy M Wheat Memorial Highway for about 88.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 18
5 decision points cluster between mile 25.1 and 161.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
7
70.4 mi into trip|~1h 26m in|US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
159.6 mi into trip|~3h 3m in|I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
7
161.7 mi into trip|~3h 5m in
Take the exit toward South US 11, North Mississippi 19: Philadelphia, Meridian Airport
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward South US 11, North Mississippi 19: Phila...
Fuel & Cost
Regular Gas
$31.41 one way
$62.83 round trip
$3.84/gal25.4 MPG avg73 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$34.48
$68.97
premium
$4.56
$37.33
$74.67
diesel
$5.61
$45.92
$91.85
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$31
Meals
$25–$50
Total
$56–$81
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 72.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $22 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
62.4
0
$21.84
$9.98
Efficient EV
52
0
$18.20
$8.32
EV Truck/SUV
83.2
1
$29.12
$13.31
Gas CO2
73 kg
EV CO2
24 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 11, 2026
Origin
Biloxi, MS
Night
in Biloxi on Saturday
Local time
11:35 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Pearl River, MS
Night
in Pearl River on Saturday
Local time
11:35 PM
CDT
Current temp
84°F
Sunny
SSE 5 mph0% chanceLive forecast
80°F
Ellisville, MS
104 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
23 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 16m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This trip offers a mixed driving profile, balancing highway efficiency with local road navigation. Approximately 55% of your journey consists of highway driving, providing a steady pace for the majority of the trip. Your longest uninterrupted stretch occurs early on, covering 88.4 miles along the Lance Corporal Roy M Wheat Memorial Highway. As you transition from the major highway segments onto US 49 and MS 19, the character of the road shifts, requiring more attention to changing speed limits and local traffic patterns. You will experience a blend of open road cruising and more standard travel conditions throughout the 208-mile distance.
55% highway, the rest on surface roads — varied driving throughout.
25 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88.4 mi on Lance Corporal Roy M Wheat Memorial Highway.
How Hard Is This Drive?
9/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 208 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Gently rolling terrain
523 ft20 ft
Total Climb
1,120 ft
Total Descent
617 ft
Highest Point
523 ft
~208 mi in
Elevation Range
503 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Pearl River, MS, road signs point toward Jackson, Laurel, Tuscaloosa, Mississippi 19: Philadelphia and Meridian Airport.
Jackson
25.1 mi in|~32m
Laurel
70.4 mi in|~1h 26m|via US 98
Tuscaloosa
159.6 mi in|~3h 3m|via I 59
Mississippi 19: Philadelphia
161.7 mi in|~3h 5m
Meridian Airport
161.7 mi in|~3h 5m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 16m. Total distance: 208 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 16m drive, comfortable solo distance.
Frequently Asked Questions
The longest stretch is about 88.4 miles on Lance Corporal Roy M Wheat Memorial Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Pearl River, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Possible but tiring. At 4.3 hours each way, an in-and-out day trip would put you behind the wheel for 8.6 hours — manageable with a long break at Pearl River, MS, but most travelers stay overnight.
